Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 22, Issue 1, Pages 14-20Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.12.003
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Funding
- Cancer Research UK
- Wellcome Trust
- Kay Kendall Leukemia Fund
- Cancer Research UK [13031] Funding Source: researchfish
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Developments in high-throughput genome analysis and in computational tools have made it possible to rapidly profile entire cancer genomes with basepair resolution. In parallel with these advances, mouse models of cancer have evolved into powerful tools for cancer gene discovery. Here we discuss some of the approaches that may be used for cancer gene identification in the mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumorigenesis.
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