Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggeringde novothymopoiesis

Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell Maturation

(2014) E. G. Houston et al.   JOURNAL OF IMMUNOLOGY

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

(2014) C. S. Lages et al.   JOURNAL OF IMMUNOLOGY

Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice

(2014) M. Ahmed et al.   JOURNAL OF IMMUNOLOGY

Adult Thymic Epithelium Contains Nonsenescent Label-Retaining Cells

(2014) M. Dumont-Lagace et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Recent Thymic Emigrants and Mature Naive T Cells Exhibit Differential DNA Methylation at Key Cytokine Loci

(2013) A. M. Berkley et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21 Accelerates Thymic Recovery from Glucocorticoïd-Induced Atrophy

(2013) Moutih Rafei et al.   PLoS One

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

(2012) K. Attridge et al.   BLOOD

Differential effects of  c cytokines on postselection differentiation of CD8 thymocytes

(2012) M. Rafei et al.   BLOOD

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors

(2012) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Development and Function of Innate Polyclonal TCR  + CD8+ Thymocytes

(2011) M. Rafei et al.   JOURNAL OF IMMUNOLOGY

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

T-cell immunosenescence: lessons learned from mouse models of aging

(2009) Alexander C. Maue et al.   TRENDS IN IMMUNOLOGY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE