Article
Medicine, General & Internal
Sanghee Park, Jihee Jung, Jiyeon Kim, Sang Bong Han, Sungweon Ryoo
Summary: This study aimed to investigate the resistance and genetic mutations of drug-resistant Mycobacterium tuberculosis (DR-Mtb) isolates to clofazimine (CFZ), in order to improve the diagnosis and treatment of drug-resistant tuberculosis (TB) patients. The results showed that the rate of CFZ resistance in drug-resistant Mtb isolates was 4.1%, and it was not related to treatment with CFZ or bedaquiline. Four novel mutation sites related to CFZ resistance were identified in this study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Abdirahman Mohamed Hassan Dirie, Sedat Colakoglu, Osman Muhyadin Abdulle, Bashir Mohamud Abdi, Mohamed Abdi Osman, Abdiaziz Mohamud Shire, Abdinafic Mohamud Hussein
Summary: The study found a prevalence of MDR-TB among pulmonary TB patients in Banadir, Somalia, which is similar to some eastern African countries.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Microbiology
Simpal Kumar Suman, Natarajan Chandrasekaran, C. George Priya Doss
Summary: Tuberculosis is a global health problem and drug resistance has made it increasingly difficult to treat. Researchers are exploring new drugs and drug delivery systems, such as nanotechnology, to combat drug resistance. However, the clinical translation of nanomedicines faces challenges such as safety, production, regulation, and intellectual property.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Deepika Sharma, Sunita Nirban, Smriti Ojha, Tarun Kumar, Neha Jain, Najwa Mohamad, Pradeep Kumar, Manisha Pandey
Summary: Tuberculosis is one of the top 10 infectious diseases globally, causing millions of deaths. Drug resistance and recurrent episodes have made the treatment challenging. Nanotechnology offers an opportunity for accurate diagnosis and effective treatment, especially through targeted drug delivery to the lungs. Therefore, research on pulmonary nanotechnology drug delivery is of great importance in overcoming drug resistance and enhancing patient compliance.
Article
Infectious Diseases
Jabar Babatunde Pacome Achimi Agbo Abdul, Bayode Romeo Adegbite, Micheska Epola Dibamba Ndanga, Jean Ronald Edoa, Rhett Chester Mevyann, Guy Rogue Arnault Ibinda Mfoumbi, Tshisekedi Jean de Dieu, Jocelyn Mahoumbou, Christopher Mebiame Biyogho, Sankarganesh Jeyaraj, Stefan Niemann, Bertrand Lell, Peter Gottfried Kremsner, Abraham Sunday Alabi, Ayola Akim Adegnika, Martin Peter Grobusch
Summary: The increasing incidence of MDR-TB infection in Gabon is alarming, especially among individuals aged 25-35. There is a need for improvement in case finding and contact tracing strategies for treatment-naive MDR-TB patients.
Review
Chemistry, Medicinal
Yashodeep Shinde, Iqrar Ahmad, Sanjay Surana, Harun Patel
Summary: Tuberculosis transmitted by Mycobacterium tuberculosis is a global concern, with drug resistance posing a significant challenge. Targeting the Mtb cell wall peptidoglycan synthesis is an attractive strategy to combat drug resistance, with Mur enzymes serving as potential targets.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Sunil Bhosale, Akil Prabhakar, Sudhir Srivastava, Aditya Raj, Shaligram Purohit, Nandan Marathe
Summary: Drug resistance in spinal tuberculosis is common, with rates of multidrug resistance, preextensive drug resistance, and extensive drug resistance found among patients in Indian subcontinent.
GLOBAL SPINE JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Madhur Jain, Sirisha Gollapudi, Gopal L. Khatik
Summary: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which primarily affects the lungs. The emergence of drug resistance has made TB treatment challenging. Targeting secreted virulence factors offers potential benefits to overcome resistance.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Genetics & Heredity
Matthias Groschel, Martin Owens, Luca Freschi, Roger Jr Jr Vargas, Maximilian G. Marin, Jody Phelan, Zamin Iqbal, Avika Dixit, Maha R. Farhat
Summary: GenTB is a free and open online tool designed to rapidly and accurately predict resistance to anti-tuberculosis drugs.
Article
Biotechnology & Applied Microbiology
Kelvin W. C. S. Leong, Sanjay S. Gautam, Manoj Pradhan, Y. Ibotomba K. Singh, K. C. R. Rajendra, Sagar Rajbhandari, Gokarna R. Ghimire, Krishna Adhikari, Uma Shrestha, Raina Chaudhary, Gyanendra Ghimire, Sundar Khadka, Ronan F. O'Toole
Summary: Nepal has a comparable tuberculosis incidence rate to its neighboring high incidence countries, and it also sees a significant number of multi-drug resistant tuberculosis cases each year. This study analyzed the whole-genome of multi-drug resistant tuberculosis isolates from Nepal and identified specific mutations related to their resistance. The study also found a high proportion of fluoroquinolone resistance among the Nepal isolates. These findings have important implications for the management of tuberculosis in Nepal.
Article
Biochemistry & Molecular Biology
Maria Alejandrina Martinez-Gonzalez, Luis Manuel Pena-Rodriguez, Andres Humberto Uc-Cachon, Jorge Borquez, Mario J. Simirgiotis, Hugo Brigido Barrios-Garcia, Rogelio Hernandez-Pando, Luis Alberto Loyola, Carlos Areche, Angel de Jesus Dzul-Beh, Jorge Alberto Barrios-Payan, Dulce Mata-Espinosa, Fabiola Escalante-Erosa, Karlina Garcia-Sosa, Gloria Maria Molina-Salinas
Summary: Tuberculosis is a leading cause of death globally, with drug-resistant strains posing a significant challenge to treatment. A new semi-synthetic mulinane derivative (1a) has shown promising anti-TB activity against drug-resistant strains and an adjuvant effect in shortening second-line chemotherapy, making it a potential candidate for the development of novel antitubercular agents.
Article
Chemistry, Medicinal
Yu Wen, Shichun Lun, Yuxue Jiao, Wei Zhang, Ting Liu, Fan Yang, Jie Tang, William R. Bishai, Li-Fang Yu
Summary: In this study, a pyridine-2-methylamine antitubercular compound was discovered using a structure-based drug design approach. Compound 62 showed the highest potency against M. tb strain H37Rv and clinically isolated MDR/XDR-TB strains, while exhibiting low toxicity to Vero cells and moderate liver microsomal stability.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Jessy Lallungawi Khawbung, Durbba Nath, Supriyo Chakraborty
Summary: Tuberculosis was declared a global emergency in 1993, and the development of drug resistance strains led to the outbreak of Multi Drug Resistant and Extensively Drug Resistant Tuberculosis. Studying the molecular mechanisms of drug resistance helps to understand the genetics and pathophysiology of the disease.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Dorothy Semenya, Meir Touitou, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Luca Pisano, Vinayak Singh, Kelly Chibale, Georg Bano, Anita Toscani, Fabrizio Manetti, Beatrice Gianibbi, Daniele Castagnolo
Summary: A series of novel indole compounds have potential anti-tuberculosis activity, with one compound showing potent antibacterial activity against laboratory and clinical Mtb strains and significant ability to inhibit the growth of Mtb in macrophages. Further investigations suggest that this compound may act on Mtb through a unique mechanism.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Dorothy Semenya, Meir Touitou, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Luca Pisano, Vinayak Singh, Kelly Chibale, Georg Bano, Anita Toscani, Fabrizio Manetti, Beatrice Gianibbi, Daniele Castagnolo
Summary: A series of indolyl-3-methyleneamines were designed and synthesized for investigation as new chemical entities against Mycobacterium tuberculosis (Mtb). Compound 7j displayed potent activity and may inhibit Mtb through a unique mechanism.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Niu-niu Zhang, Yun-xiang Tang, Lu Qian, Ya-min Gao, Zhi-yong Liu, Zhi-liang Zou, Tian-yu Zhang, Ming Yan
ARCHIV DER PHARMAZIE
(2019)
Article
Microbiology
Denis Kiplimo, Julius Mugweru, Sarah Kituyi, Alex Kipnyargis, Romano Mwirichia
JOURNAL OF BASIC MICROBIOLOGY
(2019)
Article
Microbiology
Yang Liu, Yaoju Tan, M. Mahmudul Islam, Yuanyuan Cao, Xiaoyun Lu, Sheng Zeng, H. M. Adnan Hameed, Peipei Zhou, Xingshan Cai, Shuai Wang, Julius N. Mugweru, Guoliang Zhang, Huancai Yin, Jianxiong Liu, Eric Nuermberger, Tianyu Zhang
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Plant Sciences
Zhijie Yang, Changli Sun, Zhiyong Liu, Qing Liu, Tianyu Zhang, Jianhua Ju, Junying Ma
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Infectious Diseases
Hamza Arshad Dar, Tahreem Zaheer, Nimat Ullah, Syeda Marriam Bakhtiar, Tianyu Zhang, Muhammad Yasir, Esam I. Azhar, Amjad Ali
Article
Microbiology
Sheng Zeng, Jingran Zhang, Mingwei Sun, Xiaofei Zhang, Gregory M. Cook, Tianyu Zhang
Summary: The branched electron transport chain of Mycobacterium tuberculosis allows it to resist the bactericidal action of cytochrome bc(1) inhibitors such as TB47. Combining cytochrome bc(1) inhibitors with nitric oxide donors like PMD can inhibit M. tuberculosis respiration and kill the bacteria, with the activity of the inhibitors enhanced by the presence of NO donors.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Gift Chiwala, Zhiyong Liu, Julius N. Mugweru, Bangxing Wang, Shahzad Akbar Khan, Petuel Ndip Ndip Bate, Buhari Yusuf, H. M. Adnan Hameed, Cuiting Fang, Yaoju Tan, Ping Guan, Jinxing Hu, Shouyong Tan, Jianxiong Liu, Nanshan Zhong, Tianyu Zhang
Summary: The study evaluated the therapeutic efficacy of a recombinant drug-resistant BCG vaccine against drug-resistant tuberculosis, demonstrating the stability, safety, and effectiveness of RdrBCG-I in murine models. Results suggest that the recombinant drug-resistant BCG strategy could be a promising concept for developing therapeutic vaccines against DR-TB.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Microbiology
Violah Jepkogei Kemboi, Carolyne Kipkoech, Moses Njire, Samuel Were, Mevin Kiprotich Lagat, Francis Ndwiga, John Mwibanda Wesonga, Chrysantus Mbi Tanga
Summary: The study showed that chitosan extracted from black soldier fly significantly inhibited the growth of R. solanacearum, with antibacterial activity comparable to commercial chitosan. Soil amended with BSF chitin and chitosan resulted in a reduction in bacterial wilt disease incidence and severity, showcasing the potential of insect-based chitin and chitosan as an eco-friendly control measure for R. solanacearum-induced diseases.
Article
Chemistry, Medicinal
Galina I. Buravchenko, Dmitry A. Maslov, Md Shah Alam, Natalia E. Grammatikova, Svetlana G. Frolova, Aleksey A. Vatlin, Xirong Tian, Ivan V. Ivanov, Olga B. Bekker, Maxim A. Kryakvin, Olga A. Dontsova, Valery N. Danilenko, Tianyu Zhang, Andrey E. Shchekotikhin
Summary: This study synthesized novel 2-acyl-3-trifluoromethylquinoxaline 1,4-dioxides and evaluated their antibacterial and antifungal activities. The compounds showed high antimicrobial properties against Gram-positive strains, including mycobacteria. Introduction of a halogen atom in position 6 further increased their activity. The mode of action studies confirmed their DNA-damaging nature. This study expands our understanding of quinoxaline 1,4-dioxides and may lead to the discovery of new antibacterial drugs.
Review
Plant Sciences
Consolata Nanjala, Wyclif Ochieng Odago, Peninah Cheptoo Rono, Emmanuel Nyongesa Waswa, Elizabeth Syowai Mutinda, Millicent Akinyi Oulo, Felix Wambua Muema, Vincent Okelo Wanga, Elijah Mbandi Mkala, Josiah Kuja, Moses Mucugi Njire, Guang-Wan Hu
Summary: The genus Didymocarpus is widely used in traditional medicine in Asian countries and has shown various pharmacological activities, including antiurolithiatic, nephro-protective, antimicrobial, anticancer, antidiabetic, cytotoxic, wound healing, and antioxidant activities. However, further studies on the pharmacology and toxicology of these species are needed to ensure their safety, efficacy, and quality.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Veterinary Sciences
Joseph Kiriamburi, Jamleck Muturi, Julius Mugweru, Eva Forsgren, Anna Nilsson
Summary: This study compared the biocidal effects of two commercially available disinfectants, Disinfection for Beekeeping and Virkon S, on Paenibacillus larvae. The results showed that Disinfection for Beekeeping had a higher biocidal effect on P. larvae in suspension, while Virkon S had a better effect on P. larvae on Styrofoam material. The two disinfectants had similar effects on infected wood material.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Medicinal
Svetlana G. Frolova, Aleksey A. Vatlin, Dmitry A. Maslov, Buhari Yusuf, Galina I. Buravchenko, Olga B. Bekker, Ksenia M. Klimina, Svetlana V. Smirnova, Lidia M. Shnakhova, Irina K. Malyants, Arseniy I. Lashkin, Xirong Tian, Md Shah Alam, George V. Zatonsky, Tianyu Zhang, Andrey E. Shchekotikhin, Valery N. Danilenko
Summary: Tuberculosis (TB) is one of the top 10 leading causes of global mortality, and the increasing incidence of multidrug-resistant TB highlights the urgent need for innovative anti-TB medications. In this study, new derivatives from the quinoxaline-2-carboxylic acid 1,4-dioxide class were synthesized and evaluated for their antimycobacterial activity. Compound 4 showed high activity against M. tuberculosis and low toxicity in mice. Genetic analysis confirmed the mode of action of compound 4 as a DNA-damaging agent. Overall, the derivatives of quinoxaline-2-carboxylic acid 1,4-dioxide show promise for the development of innovative antimycobacterial drugs.
Article
Agriculture, Multidisciplinary
Samuel Maina, Hannah Karuri, Julius Mugweru
Summary: This study investigated the diversity of nematodes and their correlation with soil properties in monocrop pigeon pea fields in Mbeere North, Embu County, Kenya. A total of 46 nematode genera assigned to five trophic levels were identified across the eight regions. Certain nematode genera showed significant correlations with soil attributes. The findings highlight the need for appropriate nematode management programs.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2022)
Article
Microbiology
Catherine Wachera Kiama, Moses Mucugi Njire, Anne Kelly Kambura, Julius Ndirangu Mugweru, Viviene Njeri Matiru, Eliud Nalianya Wafula, Robert Nesta Kagali, Josiah Ochieng Kuja
Summary: This study analyzed the diversity and composition of bacteria and archaea in lakes Olbolosat and Oloiden in Kenya using total community 16S rDNA. Differences in ASV composition and key elements were observed between the two lakes, with temperature playing a key role in controlling ecosystem functions.
CURRENT RESEARCH IN MICROBIAL SCIENCES
(2021)