Modulation of RAB7A Protein Expression Determines Resistance to Cisplatin through Late Endocytic Pathway Impairment and Extracellular Vesicular Secretion

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

Effect of adoption of neoadjuvant chemotherapy for advanced ovarian cancer on all cause mortality: quasi-experimental study

(2018) Alexander Melamed et al.   BMJ-British Medical Journal

Effect of adoption of neoadjuvant chemotherapy for advanced ovarian cancer on all cause mortality: quasi-experimental study

(2018) Alexander Melamed et al.   BMJ-British Medical Journal

Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization

(2017) Giulia Girolimetti et al.   HUMAN MOLECULAR GENETICS

Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes

(2017) Germana Rappa et al.   Oncotarget

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

Biocompatible multilayer capsules engineered with a graphene oxide derivative: synthesis, characterization and cellular uptake

(2016) Loretta L. del Mercato et al.   Nanoscale

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles

(2015) Nicolas Jaé et al.   FEBS LETTERS

Autophagic flux promotes cisplatin resistance in human ovarian carcinoma cells through ATP-mediated lysosomal function

(2015) LIWEI MA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma

(2015) Steffen Böhm et al.   JOURNAL OF CLINICAL ONCOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

(2015) Daniela Catanzaro et al.   Oncotarget

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

(2015) Benny Zhitomirsky et al.   Oncotarget

RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

(2014) Direna Alonso-Curbelo et al.   CANCER CELL

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit

(2014) M. De Luca et al.   JOURNAL OF CELL SCIENCE

Ovarian cancer

(2014) Gordon C Jayson et al.   LANCET

Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin

(2014) Sarah Spreckelmeyer et al.   MOLECULES

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

Contribution of intracellular ATP to cisplatin resistance of tumor cells

(2012) Verena Schneider et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance

(2012) Flora Guerra et al.   JOURNAL OF CLINICAL ONCOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function

(2011) G. Gasparre et al.   CANCER RESEARCH

Drug transporters of platinum-based anticancer agents and their clinical significance

(2011) Herman Burger et al.   DRUG RESISTANCE UPDATES

RAB8 Enhances TMEM205-Mediated Cisplatin Resistance

(2011) Ding-Wu Shen et al.   PHARMACEUTICAL RESEARCH

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In Vivo

(2010) B. G. Blair et al.   MOLECULAR PHARMACOLOGY

Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer

(2010) Ignace Vergote et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH

(2009) Cathrine Nilsson et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Ovarian Cancer

(2008) Kathleen R. Cho et al.   Annual Review of Pathology-Mechanisms of Disease

Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells

(2008) Ganna V Kalayda et al.   BMC CANCER

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology