Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
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Title
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
Authors
Keywords
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Journal
Acta Neuropathologica Communications
Volume 6, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-11-19
DOI
10.1186/s40478-018-0629-7
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Note: Only part of the references are listed.- A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism
- (2018) Bart Swinnen et al. ACTA NEUROPATHOLOGICA
- Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
- (2017) Yu Ohki et al. Molecular Neurodegeneration
- C9orf72 expansion disrupts ATM-mediated chromosomal break repair
- (2017) Callum Walker et al. NATURE NEUROSCIENCE
- Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects
- (2016) Emma Sudria-Lopez et al. ACTA NEUROPATHOLOGICA
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis
- (2016) Alexander McGown et al. Molecular Neurodegeneration
- C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
- (2016) Yuanjing Liu et al. NEURON
- Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
- (2016) Jie Jiang et al. NEURON
- Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD
- (2016) Thomas Westergard et al. Cell Reports
- Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
- (2016) Steven Boeynaems et al. Scientific Reports
- C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice
- (2016) Amanda Atanasio et al. Scientific Reports
- C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits
- (2015) Max Koppers et al. ANNALS OF NEUROLOGY
- Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish
- (2015) Fatma O. Kok et al. DEVELOPMENTAL CELL
- Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- (2015) Ana Jovičić et al. NATURE NEUROSCIENCE
- Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice
- (2015) Owen M. Peters et al. NEURON
- C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
- (2015) Jacqueline G. O’Rourke et al. NEURON
- Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
- (2015) Helene Tran et al. NEURON
- Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions inC9ORF72gene
- (2015) Atik Baborie et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions inC9orf72is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins
- (2015) Y. Davidson et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
- (2015) J. Chew et al. SCIENCE
- C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
- (2015) Johnathan Cooper-Knock et al. PLoS One
- Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
- (2014) Johnathan Cooper-Knock et al. BRAIN
- C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
- (2014) S. Mizielinska et al. SCIENCE
- Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
- (2013) Ian R. Mackenzie et al. ACTA NEUROPATHOLOGICA
- Loss of function of C9orf72 causes motor deficits in a zebrafish model of Amyotrophic Lateral Sclerosis
- (2013) Sorana Ciura et al. ANNALS OF NEUROLOGY
- Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients
- (2013) María José Mansilla et al. AUTOIMMUNITY
- RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
- (2013) T. Zu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
- (2013) Youn-Bok Lee et al. Cell Reports
- Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
- (2013) David MA Mann et al. Acta Neuropathologica Communications
- Early interneuron dysfunction in ALS: Insights from a mutantsod1zebrafish model
- (2012) Alexander McGown et al. ANNALS OF NEUROLOGY
- Measuring thigmotaxis in larval zebrafish
- (2011) S.J. Schnörr et al. BEHAVIOURAL BRAIN RESEARCH
- A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
- (2011) Ilse Gijselinck et al. LANCET NEUROLOGY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease
- (2010) T. Ramesh et al. Disease Models & Mechanisms
- Non-ATG-initiated translation directed by microsatellite expansions
- (2010) T. Zu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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