Inhibition of Mycobacterium tuberculosis L,D-Transpeptidase 5 by Carbapenems: MD and QM/MM Mechanistic Studies

Computational model for the acylation step of the β -lactam ring: Potential application for l , d -transpeptidase 2 in mycobacterium tuberculosis

(2017) Zeynab Fakhar et al.   JOURNAL OF MOLECULAR STRUCTURE

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics

(2017) Zeynab Fakhar et al.   Molecular BioSystems

Non-classical transpeptidases yield insight into new antibacterials

(2016) Pankaj Kumar et al.   Nature Chemical Biology

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

(2016) Junie Billones et al.   Drug Design Development and Therapy

Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

(2015) Giulia Manina et al.   Cell Host & Microbe

Simulating the inhibition reaction of Mycobacterium tuberculosisl,d-transpeptidase 2 by carbapenems

(2015) José Rogério A. Silva et al.   CHEMICAL COMMUNICATIONS

Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity inMycobacterium tuberculosis

(2015) Leighanne A. Brammer Basta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the cell wall ofMycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem withL,D-transpeptidase 2

(2015) José Rogério A. Silva et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development

(2015) Gleiciane Leal Moraes et al.   TUBERCULOSIS

Structure refinement based on absorption-corrected RED data

(2015) Hong Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Catalytic Mechanism of L,D-Transpeptidase 2 from Mycobacterium tuberculosis Described by a Computational Approach: Insights for the Design of New Antibiotics Drugs

(2014) José Rogério A. Silva et al.   Journal of Chemical Information and Modeling

In VitroCross-Linking of Mycobacterium tuberculosis Peptidoglycan by l,d-Transpeptidases and Inactivation of These Enzymes by Carbapenems

(2013) Mathilde Cordillot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis

(2013) Wen-Juan Li et al.   CELL RESEARCH

Biapenem Inactivation by B2 Metallo β-Lactamases: Energy Landscape of the Hydrolysis Reaction

(2013) Sharon H. Ackerman et al.   PLoS One

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2

(2012) Sabri B. Erdemli et al.   STRUCTURE

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria

(2009) H. Lam et al.   SCIENCE

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation

(2008) M. Lavollay et al.   JOURNAL OF BACTERIOLOGY