Statistically Significant Antidepressant-Placebo Differences on Subjective Symptom-Rating Scales Do Not Prove That the Drugs Work: Effect Size and Method Bias Matter!

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Withdrawal Symptoms after Serotonin-Noradrenaline Reuptake Inhibitor Discontinuation: Systematic Review

(2018) Giovanni A. Fava et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Effectiveness of antidepressants

(2018) James McCormack et al.   BMJ-British Medical Journal

Pop a million happy pills? Antidepressants, nuance, and the media

(2018) Kate Adlington   BMJ-British Medical Journal

Anticholinergic drugs and risk of dementia: case-control study

(2018) Kathryn Richardson et al.   BMJ-British Medical Journal

Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study

(2018) Rafael Gafoor et al.   BMJ-British Medical Journal

Effectiveness of antidepressants

(2018) James McCormack et al.   BMJ-British Medical Journal

Pop a million happy pills? Antidepressants, nuance, and the media

(2018) Kate Adlington   BMJ-British Medical Journal

Anticholinergic drugs and risk of dementia: case-control study

(2018) Kathryn Richardson et al.   BMJ-British Medical Journal

Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study

(2018) Rafael Gafoor et al.   BMJ-British Medical Journal

When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment

(2017) Denes Szucs et al.   Frontiers in Human Neuroscience

The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis

(2017) Marta M. Maslej et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Efficacy of antidepressants: bias in randomized clinical trials and related issues

(2017) Sheng-Min Wang et al.   Expert Review of Clinical Pharmacology

Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

(2017) Michael P. Hengartner   Frontiers in Psychiatry

The ASA's Statement onp-Values: Context, Process, and Purpose

(2016) Ronald L. Wasserstein et al.   AMERICAN STATISTICIAN

Suicidal Risks in Reports of Long-Term Controlled Trials of Antidepressants for Major Depressive Disorder II

(2016) Ross J. Baldessarini et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Meta-analyses with industry involvement are massively published and report no caveats for antidepressants

(2016) Shanil Ebrahim et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Suicides and Suicide Attempts during Long-Term Treatment with Antidepressants: A Meta-Analysis of 29 Placebo-Controlled Studies Including 6,934 Patients with Major Depressive Disorder

(2016) Cora Braun et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

(2016) André F. Carvalho et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences

(2015) Joanna Moncrieff et al.   Contemporary Clinical Trials

Effectiveness of psychological interventions in preventing recurrence of depressive disorder: Meta-analysis and meta-regression

(2015) Karolien E.M. Biesheuvel-Leliefeld et al.   JOURNAL OF AFFECTIVE DISORDERS

Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review

(2015) Giovanni A. Fava et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

What if a placebo effect explained all the activity of depression treatments?

(2015) Pim Cuijpers et al.   World Psychiatry

The Efficacy of Antidepressants on Overall Well-Being and Self-Reported Depression Symptom Severity in Youth: A Meta-Analysis

(2014) Glen I. Spielmans et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors

(2013) A. Hrobjartsson et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons

(2013) Pim Cuijpers et al.   World Psychiatry

Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses

(2012) Stefan Leucht et al.   BRITISH JOURNAL OF PSYCHIATRY

A Systematic Review of Comparative Efficacy of Treatments and Controls for Depression

(2012) Arif Khan et al.   PLoS One

Assessing the ‘true’ effect of active antidepressant therapy v. placebo in major depressive disorder: use of a mixture model

(2011) Michael E. Thase et al.   BRITISH JOURNAL OF PSYCHIATRY

Psychotherapy Versus Second-Generation Antidepressants in the Treatment of Depression

(2011) Glen I. Spielmans et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

How to Obtain NNT from Cohen's d: Comparison of Two Methods

(2011) Toshi A. Furukawa et al.   PLoS One

Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study

(2009) Jordan W. Smoller   ARCHIVES OF INTERNAL MEDICINE

Review: Problems associated with long-term treatment with selective serotonin reuptake inhibitors

(2008) C. Moret et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE