Efficacy of antidepressants: bias in randomized clinical trials and related issues

The Use of Placebos in Clinical Trials and Clinical Practice

(2017) Irving Kirsch   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

The effect of antidepressants on fertility

(2016) Marianne M. Casilla-Lennon et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

“Threshold-crossing”: A Useful Way to Establish the Counterfactual in Clinical Trials?

(2016) H-G Eichler et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficacy of Antidepressants: Issues Related to Bias in Clinical Trials

(2016) E. Spina   CLINICAL THERAPEUTICS

Are antidepressants effective? A debate on their efficacy for the treatment of major depression in adults

(2016) Tom Bschor et al.   Expert Review of Neurotherapeutics

The “Pygmalion Effect” and Surgical Mentoring

(2016) Mohan Mathew John   Indian Journal of Surgery

Statistics Commentary Series

(2016) David L. Streiner   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Precise definitions of some terminology for longitudinal clinical trials: subjects, patient populations, analysis sets, intention to treat, and related terms

(2016) Ronald W. Helms   PHARMACEUTICAL STATISTICS

Are antidepressants effective? A debate on their efficacy for the treatment of major depression in adults

(2016) Tom Bschor et al.   Expert Review of Neurotherapeutics

The Halo Effect: An Unintended Benefit of Care Pathways

(2016) Collin Barber et al.   Journal of Knee Surgery

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

(2015) Elena Dale et al.   BIOCHEMICAL PHARMACOLOGY

The role of nonrandomized trials in the evaluation of oncology drugs

(2015) R Simon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A brief history of the development of antidepressant drugs: From monoamines to glutamate.

(2015) Todd M. Hillhouse et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Predictors of placebo response in bipolar depression

(2015) Andrew A. Nierenberg et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Efficacy and safety of vilazodone 20 and 40 mg in major depressive disorder

(2015) Maju Mathews et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of 2 Doses of Vortioxetine in Adults With Major Depressive Disorder

(2015) Atul R. Mahableshwarkar et al.   JOURNAL OF CLINICAL PSYCHIATRY

Intention to treat analysis versus per protocol analysis of trial data

(2015) P. Sedgwick   BMJ-British Medical Journal

What is publication bias in a meta-analysis?

(2015) Philip Sedgwick   BMJ-British Medical Journal

Intention to treat analysis versus per protocol analysis of trial data

(2015) P. Sedgwick   BMJ-British Medical Journal

What is publication bias in a meta-analysis?

(2015) Philip Sedgwick   BMJ-British Medical Journal

Bench to Bedside

(2014) Rory B. McGoldrick et al.   HAND CLINICS

Drug promotion tactics-yet another pharma deception?

(2014) A. Tagore   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

The Role of Patient Expectancy in Placebo and Nocebo Effects in Antidepressant Trials

(2014) Bret R. Rutherford et al.   JOURNAL OF CLINICAL PSYCHIATRY

How evidence-based medicine is failing due to biased trials and selective publication

(2014) Susanna Every-Palmer et al.   JOURNAL OF EVALUATION IN CLINICAL PRACTICE

A Model of Placebo Response in Antidepressant Clinical Trials

(2013) Bret R. Rutherford et al.   AMERICAN JOURNAL OF PSYCHIATRY

Confounding control in a nonexperimental study of STAR*D data: logistic regression balanced covariates better than boosted CART

(2013) Alan R. Ellis et al.   ANNALS OF EPIDEMIOLOGY

Differential dropout and bias in randomised controlled trials: when it matters and when it may not

(2013) M. L. Bell et al.   BMJ-British Medical Journal

The placebo arm in clinical studies for treatment of Psychiatric Disorders: A Regulatory Dilemma

(2012) Christine Gispen-de Wied et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Comparing HAMD17 and HAMD subscales on their ability to differentiate active treatment from placebo in randomized controlled trials

(2012) Ruud Boessen et al.   JOURNAL OF AFFECTIVE DISORDERS

Contribution of spontaneous improvement to placebo response in depression: A meta-analytic review

(2012) Bret R. Rutherford et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Randomized clinical trials underestimate the efficacy of antidepressants in less severe depression

(2011) G. Isacsson et al.   ACTA PSYCHIATRICA SCANDINAVICA

Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials

(2011) W Rief et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Berksonʼs Bias, Selection Bias, and Missing Data

(2011) Daniel Westreich   EPIDEMIOLOGY

ECNP Summit on the future of CNS drug research in Europe 2011: Report prepared for ECNP by David Nutt and Guy Goodwin

(2011) David Nutt et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Deconstructing Pediatric Depression Trials: An Analysis of the Effects of Expectancy and Therapeutic Contact

(2011) Bret R. Rutherford et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

On the Distinction Between Interaction and Effect Modification

(2010) Tyler J. VanderWeele   EPIDEMIOLOGY

Antidepressant Drug Effects and Depression Severity

(2010) Jay C. Fournier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Review of Current Guidelines for Depression Treatment

(2010) Alan J. Gelenberg   JOURNAL OF CLINICAL PSYCHIATRY

The need for a transparent, ethical, and successful relationship between academic scientists and the pharmaceutical industry: a view of the Group for the Respect of Ethics and Excellence in Science (GREES)

(2010) O. Bruyere et al.   OSTEOPOROSIS INTERNATIONAL

Can Phase III Trial Results of Antidepressant Medications Be Generalized to Clinical Practice? A STAR*D Report

(2009) Stephen R. Wisniewski et al.   AMERICAN JOURNAL OF PSYCHIATRY

An Overview of Practical Approaches for Handling Missing Data in Clinical Trials

(2009) Cynthia M. DeSouza et al.   Journal of Biopharmaceutical Statistics

MMRM vs. LOCF: A Comprehensive Comparison Based on Simulation Study and 25 NDA Datasets

(2009) Ohidul Siddiqui et al.   Journal of Biopharmaceutical Statistics

National Patterns in Antidepressant Treatment by Psychiatrists and General Medical Providers

(2009) Ramin Mojtabai et al.   JOURNAL OF CLINICAL PSYCHIATRY

Last-Observation-Carried-Forward Imputation Method in Clinical Efficacy Trials: Review of 352 Antidepressant Studies

(2009) Stephen B Woolley et al.   PHARMACOTHERAPY

The impact of analytic method on interpretation of outcomes in longitudinal clinical trials

(2008) A. Prakash et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Evaluating solutions to sponsorship bias

(2008) M Doucet et al.   JOURNAL OF MEDICAL ETHICS

The funding crisis in psychopharmacology: an historical perspective

(2008) CA Hendrie   JOURNAL OF PSYCHOPHARMACOLOGY

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE

Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?

(2008) John PA Ioannidis   Philosophy Ethics and Humanities in Medicine

Handling drop-out in longitudinal clinical trials: a comparison of the LOCF and MMRM approaches

(2007) Peter Lane   PHARMACEUTICAL STATISTICS