Methodologies for Improving HDR Efficiency

Suppressing Ku70/Ku80 expression elevates homology-directed repair efficiency in primary fibroblasts

(2018) Guoling Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

So similar yet so different: The two ends of a double strand break

(2018) Keun P. Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway

(2018) Chris D. Richardson et al.   NATURE GENETICS

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

(2018) M. Charpentier et al.   Nature Communications

Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes

(2017) Gaelen T. Hess et al.   MOLECULAR CELL

Mismatch repair and homeologous recombination

(2016) Khek-Chian Tham et al.   DNA REPAIR

The discovery of CRISPR in archaea and bacteria

(2016) Francisco J. M. Mojica et al.   FEBS Journal

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

(2016) Yunqing Ma et al.   NATURE METHODS

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

(2016) Gaelen T Hess et al.   NATURE METHODS

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

(2016) Chu Jian Ma et al.   NUCLEIC ACIDS RESEARCH

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

(2016) K. Nishida et al.   SCIENCE

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases

(2016) Diane Yang et al.   Scientific Reports

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

(2015) Chen Yu et al.   Cell Stem Cell

The roles of CRISPR–Cas systems in adaptive immunity and beyond

(2015) Rodolphe Barrangou   CURRENT OPINION IN IMMUNOLOGY

CtIP: A DNA damage response protein at the intersection of DNA metabolism

(2015) Nodar Makharashvili et al.   DNA REPAIR

Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing

(2015) Supriya V. Vartak et al.   FEBS Journal

What history tells us XXXVII. CRISPR-Cas: The discovery of an immune system in prokaryotes

(2015) Michel Morange   JOURNAL OF BIOSCIENCES

CRISPR-Cas immunity in prokaryotes

(2015) Luciano A. Marraffini   NATURE

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

(2015) Jordan Pinder et al.   NUCLEIC ACIDS RESEARCH

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

DNA-Pairing and Annealing Processes in Homologous Recombination and Homology-Directed Repair

(2015) Scott W. Morrical   Cold Spring Harbor Perspectives in Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

(2014) U. Irion et al.   DEVELOPMENT

Nonhomologous end joining: A good solution for bad ends

(2014) Crystal A. Waters et al.   DNA REPAIR

Non-homologous end joining: Emerging themes and unanswered questions

(2014) Sarvan Kumar Radhakrishnan et al.   DNA REPAIR

Alternative end-joining pathway(s): Bricolage at DNA breaks

(2014) Philippe Frit et al.   DNA REPAIR

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Genome engineering with TALENs and ZFNs: Repair pathways and donor design

(2014) Dana Carroll et al.   METHODS

Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

(2014) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

(2014) Rodolphe Barrangou et al.   MOLECULAR CELL

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

(2014) Carolin Anders et al.   NATURE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

Microhomology-based choice of Cas9 nuclease target sites

(2014) Sangsu Bae et al.   NATURE METHODS

Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System

(2014) Kai Li et al.   PLoS One

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes

(2014) Mark D. Szczelkun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

(2014) M. Jinek et al.   SCIENCE

Mediators of Homologous DNA Pairing

(2014) A. Zelensky et al.   Cold Spring Harbor Perspectives in Biology

Regulation of DNA Pairing in Homologous Recombination

(2014) J. M. Daley et al.   Cold Spring Harbor Perspectives in Biology

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Holliday Junction Resolvases

(2014) H. D. M. Wyatt et al.   Cold Spring Harbor Perspectives in Biology

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

(2014) Steven Lin et al.   eLife

CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

(2013) Rotem Sorek et al.   Annual Review of Biochemistry

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

CRISPR-Cas systems and RNA-guided interference

(2013) Rodolphe Barrangou   Wiley Interdisciplinary Reviews-RNA

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Over-expression of RAD51 or RAD54 but not RAD51/4 enhances extra-chromosomal homologous recombination in the human sarcoma (HT-1080) cell line

(2011) Shengli Yu et al.   JOURNAL OF BIOTECHNOLOGY

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE

Tracking genome engineering outcome at individual DNA breakpoints

(2011) Michael T Certo et al.   NATURE METHODS

Evolution and classification of the CRISPR–Cas systems

(2011) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

(2011) Rimantas Sapranauskas et al.   NUCLEIC ACIDS RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Solving the RIDDLE of 53BP1 recruitment to sites of damage

(2010) Grant S. Stewart   CELL CYCLE

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection

(2010) N. A. Forrester et al.   JOURNAL OF VIROLOGY

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

(2010) Luciano A. Marraffini et al.   NATURE REVIEWS GENETICS

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

DNA Repair in Mammalian Cells

(2009) B. Pardo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

(2009)   MICROBIOLOGY-SGM

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules

(2009) J. Hilario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-based adaptive and heritable immunity in prokaryotes

(2009) John van der Oost et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

(2008) J. Gu et al.   GENES & DEVELOPMENT

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

(2008) Christoph Spycher et al.   JOURNAL OF CELL BIOLOGY

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY