Article
Cell Biology
Ruihong Zhang, Luguang Liu, Fengqin Wang, Weizhu Zhao, Kai Liu, Hang Yu, Siwei Zhao, Botao Xu, Xiaoli Zhang, Jie Chai, Jing Hao
Summary: AKAP-8L is an upregulated gene in chemoresistant gastric cancer (GC) tissues. Higher AKAP-8L expression is associated with lower survival rate in GC patients. Overexpression of AKAP-8L enhances the stemness and chemoresistance of GC cells. SCD1 plays a critical role in mediating AKAP-8L's function in GC cell stemness and chemoresistance.
CELL DEATH & DISEASE
(2022)
Article
Biology
Xinbo Qiao, Yixiao Zhang, Lisha Sun, Qingtian Ma, Jie Yang, Liping Ai, Jinqi Xue, Guanglei Chen, Hao Zhang, Ce Ji, Xi Gu, Haixin Lei, Yongliang Yang, Caigang Liu
Summary: The study found that a higher frequency of CD44(-)/CD24(-) breast cancer cells was associated with delayed breast cancer metastasis, and that RHBDL2 may play a role in breast cancer metastasis and CSC formation.
Article
Oncology
Raoud Marayati, Laura V. Bownes, Laura L. Stafman, Adele P. Williams, Colin H. Quinn, Venkatram Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth A. Beierle
Summary: RA therapy is commonly used for neuroblastoma but over half of patients relapse; SCLCCs are a subpopulation contributing to drug resistance and relapse; UAB30 was found to decrease tumorigenicity and cancer cell sternness in neuroblastoma PDXs.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Christopher Berlin, Felicie Cottard, Dominica Willmann, Sylvia Urban, Stephan M. Tirier, Lisa Marx, Karsten Rippe, Mark Schmitt, Valentina Petrocelli, Florian R. Greten, Stefan Fichtner-Feigl, Rebecca Kesselring, Eric Metzger, Roland Schuele
Summary: This study identifies lysine methyltransferase 9 (KMT9) as an important regulator in colorectal tumorigenesis. KMT9 alpha and KMT9 beta are overexpressed in colorectal cancer and colocalize with H4K12me1 at promoters of proliferation-related target genes. Ablation of KMT9 alpha significantly reduces colorectal tumorigenesis and prevents the growth of tumor organoids. Loss of KMT9 alpha impairs the maintenance and function of colorectal cancer stem/initiating cells and induces apoptosis specifically in this cellular compartment. These findings suggest that KMT9 could be a promising therapeutic target for colorectal cancer treatment.
Article
Oncology
Celia Lopez-Menendez, Alberto Vazquez-Naharro, Vanesa Santos, Pierre Dubus, Patricia G. Santamaria, Angel Martinez-Ramirez, Francisco Portillo, Gema Moreno-Bueno, Marisa M. Faraldo, Amparo Cano
Summary: This study identifies the crucial role of E2A factors in breast cancer cell sternness, metastasis, and drug resistance, suggesting the potential therapeutic vulnerability of targeting E2A proteins in breast cancer.
Article
Cell & Tissue Engineering
Angel A. Gomez-Gallegos, Lizbeth Ramirez-Vidal, Jared Becerril-Rico, Elizabeth Perez-Islas, Zuly J. Hernandez-Peralta, Mariel E. Toledo-Guzman, Alejandro Garcia-Carranca, Elizabeth Langley, Angelica Hernandez-Guerrero, Fernando Lopez-Casillas, Roberto Herrera-Goepfert, Luis F. Onate-Ocana, Elizabeth Ortiz-Sanchez
Summary: By conducting multiparametric flow cytometry analysis, we identified an extended phenotype for gastric cancer stem cells (GCSCs) that can provide better identification and development of therapeutic targets. CD24+CD44+CD54+EpCAM+ cells were present in all treatment-naive patients with gastric cancer and their percentage was correlated with TNM staging and metastatic potential.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Patrizia Malkomes, Ilaria Lunger, Elsie Oppermann, Khalil Abou-El-Ardat, Thomas Oellerich, Stefan Guenther, Can Canbulat, Sabrina Bothur, Frank Schnuetgen, Weijia Yu, Susanne Wingert, Nadine Haetscher, Claudia Catapano, Marina S. Dietz, Mike Heilemann, Hans-Michael Kvasnicka, Katharina Holzer, Hubert Serve, Wolf Otto Bechstein, Michael A. Rieger
Summary: TGM2 plays a crucial role in colorectal cancer, with its transamidation activity being essential for promoting cell survival. By binding to the tumor suppressor gene p53, TGM2 inactivates it, affecting apoptosis induction in cancer cells.
Article
Integrative & Complementary Medicine
Li Yue-jun, Liao Lin-li, Liu Pei, Tang Ping, Wang Hong, Peng Qing-hua
Summary: SJZD inhibits the development and proliferation of gastric cancer stem cells by attenuating the transcriptional activity of beta-catenin.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Mathematical & Computational Biology
Jihong Yang, Hao Xu, Congshu Li, Zhenhao Li, Zhe Hu
Summary: In this study, using transcriptomic data from embryonic stem cells, potential cancer stemness genes were identified, and a breast cancer stemness network was constructed. Furthermore, by analyzing the correlation between chemical perturbations and stemness marker genes, several drugs with potential inhibitory effects on stemness were predicted.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Siu Hong Dexter Wong, Xiao Xu, Xi Chen, Ying Xin, Limei Xu, Chun Him Nathanael Lai, Jiwon Oh, Wai Ki Ricky Wong, Xuemei Wang, Shisong Han, Wenxing You, Xintao Shuai, Nathalie Wong, Youhua Tan, Li Duan, Liming Bian
Summary: The use of a magnetic nanoplatform was found to efficiently culture cancer cells with stem cell-like features, aiding in understanding tumor development mechanisms and establishing tumor models. Substrates with high ligand mobility suppressed integrin-mediated mechanotransduction, enhancing cancer cell stemness.
Article
Biochemistry & Molecular Biology
Shiran Shapira, Eynat Finkelshtein, Dina Kazanov, Esmira Naftali, Irena Stepansky, Abraham Loyter, Daniel Elbirt, Mori Hay-Levy, Eli Brazowski, Faina Bedny, Roy Dekel, Dov Hershkovitz, Arye Blachar, Ido Wolf, Nadir Arber
Summary: A novel targeted cancer therapeutic platform based on lentiviral integrase stimulated by integrase-derived peptides specifically delivered to cancer cells via CD24 antigen-antibody targeting is proposed. The platform leads to apoptosis in tumor cells by inducing genomic instability, presenting a potentially effective and safe approach for selective cancer cell eradication.
Article
Biochemistry & Molecular Biology
Jiadi Lv, Yaoping Liu, Feiran Cheng, Jiping Li, Yabo Zhou, Tianzhen Zhang, Nannan Zhou, Cong Li, Zhenfeng Wang, Longfei Ma, Mengyu Liu, Qiang Zhu, Xiaohan Liu, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Yi Fang, Haizeng Zhang, Ning Wang, Yuying Liu, Bo Huang
Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.
Article
Oncology
Ziyi Zhao, Jinhao Zeng, Qiang Guo, Kunming Pu, Yi Yang, Nianzhi Chen, Gang Zhang, Maoyuan Zhao, Qiao Zheng, Jianyuan Tang, Qiongying Hu
Summary: Berberine was found to inhibit tumor growth and stemness in colorectal cancer stem-like cells by decreasing m(6)A methylation, regulating FTO, and downregulating beta-catenin. This led to decreased cell proliferation, induced cell cycle arrest, reduced colony formation, and increased chemosensitivity, ultimately inhibiting malignant behaviors in colorectal CSCs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Caigang Liu, Yixiao Zhang, Jiujiao Gao, Qi Zhang, Lisha Sun, Qingtian Ma, Xinbo Qiao, Xinnan Li, Jinchi Liu, Jiawen Bu, Zhan Zhang, Ling Han, Dongyu Zhao, Yongliang Yang
Summary: This study reports the discovery and biological evaluation of a highly potent small-molecule antagonist, LFS-1107, targeting breast cancer stem-like cells (BCSCs) in triple-negative breast cancer (TNBC). LFS-1107 selectively eliminates CD44(+)CD24(-) enriched BCSCs and shows significant inhibitory effects on TNBC tumor cells. These findings provide preclinical evidence that LFS-1107 could be a promising therapeutic agent for the treatment of TNBC.
DRUG RESISTANCE UPDATES
(2023)
Article
Biochemistry & Molecular Biology
Tianzhi Huang, Yongyong Yang, Xiao Song, Xuechao Wan, Bingli Wu, Namratha Sastry, Craig M. Horbinski, Chang Zeng, Deanna Tiek, Anshika Goenka, Fabao Liu, Cameron W. Brennan, John A. Kessler, Roger Stupp, Ichiro Nakano, Erik P. Sulman, Ryo Nishikawa, Charles David James, Wei Zhang, Wei Xu, Bo Hu, Shi-Yuan Cheng
Summary: This study reveals that a CK2 alpha-PRMT6-RCC1 signaling axis plays a crucial role in the stem-like properties and tumor biology of GSCs, contributing to chromatin condensation, mitosis, and overall malignancy in GBM. EPZ020411, a specific small-molecule inhibitor for PRMT6, shows potential as a therapeutic target for treating GBM by suppressing RCC1 arginine methylation and enhancing the efficacy of radiotherapy against GSC brain tumor xenografts.
Article
Biochemistry & Molecular Biology
Frederic Perros, Pierre Sentenac, David Boulate, Gregoire Manaud, Tom Kotsimbos, Florence Lecerf, Lilia Lamrani, Elie Fadel, Olaf Mercier, Arturo Londono-Vallejo, Marc Humbert, Saadia Eddahibi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Timo Reislander, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londono-Vallejo, Madalena Tarsounas
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Emilia Puig Lombardi, Arturo Londono-Vallejo
NUCLEIC ACIDS RESEARCH
(2020)
Article
Oncology
Charles Fouillade, Sandra Curras-Alonso, Lorena Giuranno, Eddy Quelennec, Sophie Heinrich, Sarah Bonnet-Boissinot, Arnaud Beddok, Sophie Leboucher, Hamza Umut Karakurt, Mylene Bohec, Sylvain Baulande, Marc Vooijs, Pierre Verrelle, Marie Dutreix, Arturo Londono-Vallejo, Vincent Favaudon
CLINICAL CANCER RESEARCH
(2020)
Correction
Biochemistry & Molecular Biology
A. Takedachi, E. Despras, S. Scaglione, R. Guerois, J. H. Guervilly, M. Blin, S. Audebert, L. Camoin, Z. Hasanova, M. Schertzer, A. Guille, D. Churikov, I. Callebaut, V. Naim, M. Chaffanet, J. P. Borg, F. Bertucci, P. Revy, D. Birnbaum, A. Londono-Vallejo, P. L. Kannouche, P. H. L. Gaillard
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
A. Takedachi, E. Despras, S. Scaglione, R. Guerois, J. H. Guervilly, M. Blin, S. Audebert, L. Camoin, Z. Hasanova, M. Schertzer, A. Guille, D. Churikov, I Callebaut, V Naim, M. Chaffanet, J. P. Borg, F. Bertucci, P. Revy, D. Birnbaum, A. Londono-Vallejo, P. L. Kannouche, P. H. L. Gaillard
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Eleonore Toufektchan, Vincent Lejour, Romane Durand, Neelam Giri, Irena Draskovic, Boris Bardot, Pierre Laplante, Sara Jaber, Blanche P. Alter, Jose-Arturo Londono-Vallejo, Sharon A. Savage, Franck Toledo
Article
Cell Biology
Andrea Bjorkman, Soren L. Johansen, Lin Lin, Mike Schertzer, Dimitris C. Kanellis, Anna-Maria Katsori, Soren T. Christensen, Yonglun Luo, Jens S. Andersen, Simon J. Elsasser, Arturo Londono-Vallejo, Jiri Bartek, Kenneth B. Schou
GENES & DEVELOPMENT
(2020)
Article
Biochemistry & Molecular Biology
Julien Jarroux, Dominika Foretek, Claire Bertrand, Marc Gabriel, Ugo Szachnowski, Zohra Saci, Shuling Guo, Arturo Londono-Vallejo, Marina Pinskaya, Antonin Morillon
Summary: The research reveals that the interaction between HOTAIR and LSD1 promotes the migration of epithelial cells and induces partial reprogramming of the epithelial transcriptome by altering LSD1 distribution at promoter and enhancer regions. This uncovers an unexpected role of HOTAIR in EMT as an LSD1 decommissioning factor, counteracting its activity in the control of epithelial identity.
Editorial Material
Respiratory System
Sandra Curras-Alonso, Juliette Soulier, Thomas Walter, Florian Mueller, Arturo Londono-Vallejo, Charles Fouillade
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Biochemistry & Molecular Biology
Larissa Lipskaia, Pauline Maisonnasse, Charles Fouillade, Valentin Sencio, Quentin Pascal, Jean-Michel Flaman, Emmanuelle Born, Arturo London-Vallejo, Roger Le Grand, David Bernard, Francois Trottein, Serge Adnot
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Editorial Material
Respiratory System
Charles Fouillade, Arturo Londono-Vallejo
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Samar Ali, Emilia Puig Lombardi, Deepanjan Ghosh, Tao Jia, Geraldine Vitry, Lina Saker, Joel Poupon, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londono-Vallejo, Sophie Bombard
Summary: Pt-ttpy shows dual targeting efficiency on DNA by inducing telomere dysfunction and genomic DNA damage at specific loci, while not particularly accumulating in potential G4 forming sequences.
Article
Biochemistry & Molecular Biology
Lucas T. Gray, Emilia Puig Lombardi, Daniela Verga, Alain Nicolas, Marie-Paule Teulade-Fichou, Arturo Londono-Vallejo, Nancy Maizels
CELL CHEMICAL BIOLOGY
(2019)
Article
Biology
Marina Pinskaya, Zohra Saci, Melina Gallopin, Marc Gabriel, Ha T. N. Nguyen, Virginie Firlej, Marc Descrimes, Audrey Rapinat, David Gentien, Alexandre de la Taille, Arturo Londono-Vallejo, Yves Allory, Daniel Gautheret, Antonin Morillon
LIFE SCIENCE ALLIANCE
(2019)