Article
Oncology
Yue Shi, Chong Liu
Summary: Hsa_circ_0043278 acts as a tumor suppressor gene in breast cancer by regulating the hsa_circ_0043278/miR-455-3p/EI24 axis, suggesting its potential as a new prognostic predictor or therapeutic target in breast cancer.
Article
Cell Biology
Na Luo, Shiqin Liu, Xin Li, Yu Hu, Kejing Zhang
Summary: The study revealed that circHIPK3 promotes breast cancer growth and metastasis by sponging miR-326. Overexpression of circHIPK3 enhanced proliferation, migration, invasion, apoptosis resistance, and tumor growth, while these effects were partially reversed by miR-326 overexpression. This suggests a novel therapeutic target for breast cancer treatment.
Article
Medicine, Research & Experimental
Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu, Qi Zhang
Summary: This study identified a novel circRNA-based mechanism involved in breast cancer progression, revealing the correlation between circRNA-miRNA-m6A modulators and providing new diagnostic and therapeutic strategies for combating breast cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Lei Gao, Xiaolong Tang, Qingsi He, Guorui Sun, Chao Wang, Hui Qu
Summary: In this study, we found that the upregulation of circCOG2 in colorectal cancer (CRC) promoted tumor proliferation, migration, and invasion through the miR-1305/TGF-beta 2/SMAD3 pathway. Furthermore, the effect of circCOG2 could be transmitted via exosomes from CRC cells with high metastatic potential to those with low metastatic potential, suggesting a potential therapeutic target for CRC.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Jianming Lu, Chuanfan Zhong, Junqi Luo, Fangpeng Shu, Daojun Lv, Zezhen Liu, Xiao Tan, Shuo Wang, Kaihui Wu, Taowei Yang, Weibo Zhong, Bin Wang, Yanfei Chen, Yuehan Li, Zhenyu Jia, Yaguang Zou, Weide Zhong, Xiangming Mao
Summary: This study demonstrated the biological relevance of circCSPP1 and HnRNP-L in the progression of prostate cancer, indicating that increased circCSPP1 in prostate cancer cells regulated by HnRNP-L can induce autophagy, leading to enhanced proliferation, migration, and invasion. Furthermore, a potential competing endogenous RNA network involving circCSPP1, miR-520h, and EGR1 was revealed in prostate cancer cells, suggesting its significance in prostate cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Yu Guo, Tian-Tian Liu, Wen-Jie Zhu, Hai-Ting Liu, Guo-Hao Zhang, Lin Song, Rui-Nan Zhao, Xu Chen, Peng Gao
Summary: This study reveals the tumor-suppressor role of circKDM4B in breast cancer, especially in inhibiting tumor growth, metastasis, and angiogenesis, making it a potential therapeutic target for breast cancer progression.
Article
Cell Biology
Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang, Yuanting Gu
Summary: circNOL10 is down-regulated in breast cancer tissues and cells, and its low expression is associated with tumor size, TNM stage, lymph node metastasis, and poor prognosis. It acts as a sponge for miR-767-5p to up-regulate SOCS2 and inactivate the JAK2/STAT5 pathway, thereby repressing breast cancer development.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Oncology
Wen-Bin Wang, Ping Ren, Fei-Hua Ren, Ming Huang, Xing Cheng
Summary: The study showed that circ_0000526 was downregulated in breast cancer samples and correlated with unfavorable pathological indexes. Circ_0000526 significantly inhibited the proliferation and metastasis of breast cancer cells, and promoted apoptosis. By binding with miR-492, circ_0000526 indirectly enhanced the expression of tumor suppressor SOCS2.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Multidisciplinary Sciences
Ming Wang, Ming Li, Zehan Liu, Cuinan Jiang, Hailong Lv, Qin Yang
Summary: The study aimed to investigate the role of circ_0128846 in pancreatic cancer (PC) and its interaction with miR-1270 and NR3C1. The results showed that circ_0128846 was highly expressed in PC and its deficiency inhibited cancer cell proliferation, colony formation, migration, and tumor growth. Circ_0128846 directly targeted miR-1270, which was downregulated in PC. Inhibition of miR-1270 partially reversed the suppressive effects of circ_0128846 silencing on PC progression. Furthermore, miR-1270 targeted NR3C1, and its knockdown partially abolished the repressive effects on PC cell malignant phenotypes. Our findings suggest that circ_0128846 functions as a potential biomarker and mediator in PC through the miR-1270/NR3C1 pathway.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Gang Ma, Guichen Li, Wufeng Fan, Yuanhong Xu, Shaowei Song, Kejian Guo, Zhe Liu
Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Chen Yang, Zezhong Mou, Zheyu Zhang, Siqi Wu, Quan Zhou, Yiling Chen, Jian Gong, Chenyang Xu, Yuxi Ou, Xinan Chen, Xiyu Dai, Haowen Jiang
Summary: Our study revealed the tumor suppressive role of circRBPMS in bladder cancer by targeting the miR-330-3p/RAI2 axis, leading to inhibition of cell proliferation and metastasis. Downregulation of circRBPMS is associated with aggressive bladder cancer, while upregulation can suppress cell proliferation and migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He
Summary: This study found that circ_0042881 is highly expressed in breast cancer and is closely associated with clinical features. The study revealed that circ_0042881 promotes breast cancer progression by sponging miR-217, which activates the RAS protein and initiates downstream signaling pathways.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hong Chen, Ling-Fei Zhang, Lu Zhang, Ying Miao, Yun Xi, Mo-Fang Liu, Min Zhang, Biao Li
Summary: A circular RNA, circANKRD17, is found to function as a key regulator in promoting glycolysis in breast cancer cells, leading to cell growth, migration, invasion, and cell-cycle progression. CircANKRD17 acts as a sponge for miR-143, relieving the suppressive effect of miR-143 on hexokinase 2 and enhancing glycolysis in breast cancer cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)