Article
Immunology
Lieh-bang Liou, Chih-chieh Chen, Wen-yu Chiang, Meng-hsin Chen
Summary: This study investigated the effects of sialylated and de-SIA IgG anti-dsDNA antibodies on lupus mouse proteinuria and explored potential mechanisms. The results showed that highly sialylated antibodies alleviated the severity of proteinuria, while de-SIA antibodies worsened proteinuria. The study also found that highly sialylated antibodies resulted in changes in levels of certain cytokines in the serum.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Balamurugan A. Vellayappan, Tresa McGranahan, Jerome Graber, Lynne Taylor, Vyshak Venur, Richard Ellenbogen, Andrew E. Sloan, Kristin J. Redmond, Matthew Foote, Samuel T. Chao, John H. Suh, Eric L. Chang, Arjun Sahgal, Simon S. Lo
Summary: Intracranial stereotactic radiosurgery (SRS) is an effective treatment for many brain conditions, but patient selection is crucial to avoid complications. Mitigation strategies should be considered, especially for high-risk patients, to ensure successful treatment outcomes.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Oncology
Jens Tijtgat, Evan Calliauw, Iris Dirven, Manon Vounckx, Randa Kamel, Anne Marie Vanbinst, Hendrik Everaert, Laura Seynaeve, Dirk Van Den Berge, Johnny Duerinck, Bart Neyns
Summary: Focal radiation necrosis of the brain (fRNB) is a potential adverse event following stereotactic radiation therapy (SRT) or stereotactic radiosurgery (SRS), with higher incidence in cancer patients treated with immune checkpoint inhibitors. A low-dose regimen of bevacizumab (BEV) was found to be effective in improving clinical symptoms and reducing edema volume in fRNB patients, without significant adverse effects. This fixed low-dose BEV regimen may serve as a well-tolerated and cost-effective alternative treatment option for fRNB, warranting further investigation.
Review
Immunology
Alessandra Vultaggio, Margherita Perlato, Francesca Nencini, Emanuele Vivarelli, Enrico Maggi, Andrea Matucci
Summary: Biologicals are commonly used for rheumatologic diseases, cancers, and chronic inflammatory conditions, but they may lead to the development of anti-drug antibodies (ADA), limiting their clinical usage due to safety concerns. Strategies such as concomitant immunosuppressive treatment and regular infusion regimens can help reduce the risk of immediate hypersensitivity reactions (HSRs) associated with ADA. Drug desensitization (DD) may be considered for patients needing reintroduction of the biological culprit, especially in cases of IgE-mediated HSRs, potentially inhibiting mast cell degranulation and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Tanja Eichkorn, Jonathan W. Lischalk, Elisabetta Sandrini, Eva Meixner, Sebastian Regnery, Thomas Held, Julia Bauer, Emanuel Bahn, Semi Harrabi, Juliane Hoerner-Rieber, Klaus Herfarth, Juergen Debus, Laila Koenig
Summary: Radiation-induced contrast enhancements (RICE) are a common side effect following radiotherapy for gliomas, and correct diagnosis and treatment decisions for RICE are challenging. Research shows that different treatments result in varying outcomes for RICE, emphasizing the importance of making the right treatment decisions.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Angela Barillaro, Mara Caroprese, Laura Cella, Anna Viggiano, Francesca Buccelli, Chiara Daponte, Chiara Feoli, Caterina Oliviero, Stefania Clemente, Antonio Farella, Manuel Conson, Roberto Pacelli
Summary: Brain metastases are severe events in patients with solid tumors. Stereotactic radiation therapy is an effective treatment for brain metastases, but it may lead to radiation necrosis, which can impact patient's quality of life. Prompt recognition and treatment are necessary for managing radiation necrosis.
Article
Biochemistry & Molecular Biology
Chaeyeong Kim, Hyunchae Sim, Jong-Sup Bae
Summary: This study found that benzoylpaeoniflorin (BPF) has a mitigating effect on LPS-induced septic conditions and can protect mice from sepsis caused by cecal ligation and puncture (CLP). In addition, BPF inhibits the expression of key pro-inflammatory molecules in LPS-induced inflammatory cells and suppresses the phosphorylation levels of NF-κB and MAPKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Michal Braczkowski, Dariusz Soszynski, Alicja Sierakowska, Ryszard Braczkowski, Klaudia Kufel, Beata Labuz-Roszak
Summary: Encephalitis is a complex condition with various causes and symptoms. Autoimmune encephalitis, which accounts for about 4% of encephalitis cases, is caused by autoantibodies attacking the central nervous system. This paper discusses the mental and neurological symptoms of autoimmune encephalitis, as well as the coexistence with psychosis and neoplastic diseases. Early diagnosis and targeted treatment are emphasized for a successful therapeutic process. The research methodology involved searching for articles from 2007 to 2023 using search engines like PubMed and Medline.
Article
Multidisciplinary Sciences
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Summary: This study utilized immunodeficient NOG-Fc gamma R-/- mice to evaluate the anti-cancer effects of nivolumab, an anti-PD-1 antibody, and found that the effects were more clearly detected in NOG-Fc gamma R-/- mice compared to NOG mice.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr
Summary: This study investigated whether the neurotoxic effects of methotrexate could be improved by administering Spirulina platensis and/or thymoquinone. The results showed that combining methotrexate with either Spirulina platensis or thymoquinone significantly reduced its harmful effects, leading to a faster recovery of biochemical markers, oxidative markers, inflammatory responses, and cell death to normal levels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Immunology
Xiaopei Cui, Huifeng Jia, Hong Xin, Lei Zhang, Shi Chen, Simin Xia, Xue Li, Wei Xu, Xiaofang Chen, Yujie Feng, Xiaoyue Wei, Haijia Yu, Yanting Wang, Yifan Zhan, Xiangyang Zhu, Xuemei Zhang
Summary: The novel bispecific antibody HB0025, targeting multiple immune checkpoints, demonstrates greater efficacy in inhibiting cancer growth compared to single antibodies, potentially providing broader clinical benefits and indications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Simon Wabitsch, John C. McVey, Chi Ma, Benjamin Ruf, Olena Kamenyeva, Justin D. McCallen, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Summary: This study evaluated the impact of HCQ treatment on the efficacy of anti-PD1 tumor immunotherapy and found that it can lead to immunotherapy failure due to its immunosuppressive effects that offset both increased MHC-I expression by tumor cells and direct cytotoxicity.
Article
Oncology
Matthias Demetz, Julian Mangesius, Aleksandrs Krigers, Meinhard Nevinny-Stickel, Claudius Thome, Christian F. Freyschlag, Johannes Kerschbaumer
Summary: This study assessed the correlation between tumor location and the development of radiation necrosis (RN) for skull base and non-skull base tumors. It found that skull base tumors had a significantly lower risk of RN, independently of the radiation dose. Additionally, higher radiation doses were associated with a higher risk of RN. The findings support the value of radiosurgical treatment for patients with recurrent skull base tumors.
Article
Oncology
William C. Newman, Jacob Goldberg, Sergio W. Guadix, Samantha Brown, Anne S. Reiner, Katherine Panageas, Kathryn Beal, Cameron W. Brennan, Viviane Tabar, Robert J. Young, Nelson S. Moss
Summary: Resection of radiation necrosis leads to durable reduction in T2-FLAIR signal, correlated with extent of resection, and decreased steroid dependency for surviving patients.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Neurosciences
Dina Rodrigues Martins, Marc Vandermeeren, Kristof Van Kolen, Eddy Brepoels, Marianne Borgers, Cindy Wintmolders, Charlotte Delay, Astrid Bottelbergs, Marc Mercken, Clara Theunis
Summary: Researchers developed specific antibodies to detect mouse tau protein, which showed high specificity and can be used to detect tau in mouse brain homogenate and cerebrospinal fluid, as well as to detect aggregation of endogenous mouse tau. These antibodies are important tools to interpret results from different model systems and study the role of endogenous tau in tau aggregation and pathology observed in diverse mouse models.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Jingxia Liu, Chengjie Xiong, Lei Liu, Guoqiao Wang, Luo Jingqin, Feng Gao, Ling Chen, Yan Li
Summary: This study investigates the impact of equal versus unequal cluster sizes on treatment effects in cluster randomized trials, suggesting that increasing the number of clusters can compensate for efficiency loss due to different cluster sizes.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junzhong Xu, Xiaoyu Jiang, Sean P. Devan, Lori R. Arlinghaus, Eliot T. McKinley, Jingping Xie, Zhongliang Zu, Qing Wang, A. Bapsi Chakravarthy, Yong Wang, John C. Gore
Summary: The study presents a new MRI-cytometry method for noninvasively mapping nonparametric cell size distributions in tissues. Results from simulations and experiments confirm the reliability of the method in mapping cell size distributions, with potential applications in breast cancer patients.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Oncology
Jennifer A. Foltz, Brian T. Hess, Veronika Bachanova, Nancy L. Bartlett, Melissa M. Berrien-Elliott, Ethan McClain, Michelle Becker-Hapak, Mark Foster, Timothy Schappe, Brad Kahl, Neha Mehta-Shah, Amanda F. Cashen, Nancy D. Marin, Kristen McDaniels, Chaz Moreno, Matthew Mosior, Feng Gao, Obi L. Griffith, Malachi Griffith, Julia A. Wagner, Narendranath Epperla, Amy D. Rock, John Lee, Allegra A. Petti, Patrick Soon-Shiong, Todd A. Fehniger
Summary: The combination therapy of N-803 with rituximab demonstrated safety and durable clinical responses in patients with indolent non-Hodgkin lymphoma, including rituximab-refractory patients. Analysis using CITE-seq revealed altered molecular programs in NK cells and monocytes post-treatment, suggesting the potential for further investigation of N-803 in combination with immunotherapies.
CLINICAL CANCER RESEARCH
(2021)
Article
Statistics & Probability
Jingqin Luo, Feng Gao, Jingxia Liu, Guoqiao Wang, Ling Chen, Anne M. Fagan, Gregory S. Day, Jonathan Voeglein, Jasmeer P. Chhatwal, Chengjie Xiong
Summary: Bivariate correlation coefficients are commonly used in medical research to assess the relationship between two variables. In a family-type clustered design, BCCs can be defined and estimated at various hierarchical levels. Simulation studies were conducted to evaluate the performance of proposed estimators.
JOURNAL OF APPLIED STATISTICS
(2022)
Article
Oncology
Foluso O. Ademuyiwa, Ina Chen, Jingqin Luo, Mothaffar F. Rimawi, Ian S. Hagemann, Bryan Fisk, Gejae Jeffers, Zachary L. Skidmore, Anamika Basu, Megan Richters, Cynthia X. Ma, Katherine Weilbaecher, Jennifer Davis, Rama Suresh, Lindsay L. Peterson, Ron Bose, Nusayba Bagegni, Caron E. Rigden, Ashley Frith, Timothy P. Rearden, Leonel F. Hernandez-Aya, Anna Roshal, Katherine Clifton, Mateusz Opyrchal, Olaronke Akintola-Ogunremi, Byung Ha Lee, Sara Ferrando-Martinez, Sarah E. Church, Meenakshi Anurag, Matthew J. Ellis, Feng Gao, William Gillanders, Obi L. Griffith, Malachi Griffith
Summary: Neoadjuvant docetaxel and carboplatin resulted in a pCR rate of 45.7% in TNBC patients. Whole-exome sequencing and immune profiling were able to differentiate patients with and without pCR.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Kian-Huat Lim, Mateusz Opyrchal, Abhi Acharya, Nick Boice, Ningying Wu, Feng Gao, Jace Webster, Albert C. Lockhart, Saiama N. Waqar, Ramaswamy Govindan, Daniel Morgensztern, Joel Picus, Benjamin R. Tan, Maria Q. Baggstrom, Christopher A. Maher, Andrea Wang-Gillam
Summary: The study evaluated the efficacy and safety of the combination of AURKA inhibitor (alisertib) and paclitaxel in patients with refractory high-grade neuroendocrine tumors (NETs). The combination treatment demonstrated manageable side-effect profile and promising preliminary efficacy in high-grade NETs, warranting further testing.
EUROPEAN JOURNAL OF CANCER
(2021)
Letter
Oncology
Sena Kim, Kidist Ashami, Sora Lim, Karl Staser, Kiran Vij, Srikanth Santhanam, Julie Ritchey, Sarah Peterson, Feng Gao, Matthew A. Ciorba, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Letter
Oncology
Lawrence Liu, Mark Fiala, Feng Gao, Justin King, Scott Goldsmith, Tanya M. Wildes, Keith Stockerl-Goldstein, Ravi Vij, Mark A. Schroeder
Summary: The study found that 2nd-line DPd has a high efficacy in standard risk myeloma but lower efficacy in high risk myeloma, suggesting a need for further investigation.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Joel R. Garbow, Tanner M. Johanns, Xia Ge, John A. Engelbach, Liya Yuan, Sonika Dahiya, Christina I. Tsien, Feng Gao, Keith M. Rich, Joseph J. H. Ackerman
Summary: The study showed that previous radiation can lead to aggressive tumor growth and decreased response to PD-L1 therapy in a mouse model. The (RIM)-M-2 model highlights the impact of radiation on subsequent tumor growth and immunotherapy response, emphasizing the need for further investigation into the effects of radiation on therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Jingyu Xiang, Min Shi, Mark A. Fiala, Feng Gao, Michael P. Rettig, Geoffrey L. Uy, Mark A. Schroeder, Katherine N. Weilbaecher, Keith E. Stockerl-Goldstein, Shamim Mollah, John F. DiPersio
Summary: Mobilized peripheral blood has become the primary source of hematopoietic stem cells. This study compared different mobilization regimens and developed a machine learning model to predict inadequate stem cell yields in allogeneic donors.
Article
Biology
Horng-Shiuann Wu, F. Gao, L. Yan, C. Given
Summary: The study found that light therapy can significantly improve post-treatment fatigue and subjective sleep quality in female survivors of breast cancer who still experience fatigue and sleep disruption 1-3 years after completing chemotherapy and/or radiation. Additionally, unexpected benefits of dim light on sleep were observed, improving some sleep parameters.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Jiang, Eliot T. McKinley, Jingping Xie, John C. Gore, Junzhong Xu
Summary: In this study, MRI-measured cell size was used as a new imaging biomarker to assess chemotherapy response in breast cancer. The results showed that the cell size of paclitaxel-treated cells significantly increased after 24 hours of treatment and decreased at later weeks. These findings were supported by flowcytometry, light microscopy, and histology. The study provides a new approach for evaluating therapeutic response in breast cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junzhong Xu, Jingping Xie, Natenael B. Semmineh, Sean P. Devan, Xiaoyu Jiang, John C. Gore
Summary: This study aims to quantify the variations of the power-law dependences on diffusion time t or gradient frequency f of extracellular water diffusion measured by diffusion MRI (dMRI). The results suggest that different power-law functions can better describe the behavior of extracellular diffusion depending on the range of diffusion time in practical dMRI.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Hematology
Michael Slade, Mark A. Fiala, Marie Kirchmeyer, Jeff King, Feng Gao, Mark A. Schroeder, A. Keith Stewart, Keith Stockerl-Goldstein, Christine Chen, Ravi Vij
Summary: This study investigates the use of elotuzumab, pomalidomide, and dexamethasone (EPd) as salvage therapy prior to and maintenance after second autologous hematopoietic cell transplantation (AHCT2) for relapsed multiple myeloma. The results show that EPd maintenance after AHCT2 is safe and tolerable, with similar 1-year progression-free survival (PFS) and median PFS compared to previous studies.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Lawrence Wayne Liu, Alicia Yn, Feng Gao, Marissa Olson, Mallory Crain, Ramzi Abboud, Peter Westervelt, Camille Abboud, Ravi Vij, Keith Stockerl-Goldstein, Iskra Pusic, Amanda F. Cashen, Mark A. Schroeder
Summary: Letermovir is effective in preventing CMV infection in CMV seropositive recipients. This study provides data on the incidence of csCMVi and overall survival beyond the initial 24 weeks after alloSCT. It also identifies risk factors for CMV-related mortality and suggests the possible need for extended use of letermovir.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)