The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease

Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease

(2018) Liming Mao et al.   JOURNAL OF CLINICAL INVESTIGATION

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition

(2017) Michail Mamantopoulos et al.   IMMUNITY

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP6: A Multifaceted Innate Immune Sensor

(2017) Maayan Levy et al.   TRENDS IN IMMUNOLOGY

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis

(2017) Xiaomin Yao et al.   Nature Communications

NLRP6 Protects Il10 −/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

(2017) Sergey S. Seregin et al.   Cell Reports

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation

(2017) Adrian J. Błażejewski et al.   Cell Reports

Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure

(2017) Eric J.C. Gálvez et al.   Cell Reports

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency

(2016) Dror S. Shouval et al.   GASTROENTEROLOGY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

(2016) Ling Liu et al.   Journal of Crohns & Colitis

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

ATPL2 (MAP3K8)disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion

(2015) Matija Hedl et al.   GUT

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

(2015) Sang-Uk Seo et al.   IMMUNITY

Tr1 Cells, but Not Foxp3+Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism

(2015) Yu Yao et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Caspase-11 during Acute Experimental Murine Colitis

(2014) Katarzyna Oficjalska et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

(2014) D Demon et al.   Mucosal Immunology

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

(2014) Antonella de Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

(2012) Niall S. Kenneth et al.   BIOCHEMICAL JOURNAL

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis

(2011) Frederic A Carvalho et al.   GUT

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY