How to study sex differences in addiction using animal models

Sex differences in drug addiction and response to exercise intervention: From human to animal studies

(2016) Yuehui Zhou et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward

(2016) Marilyn E. Carroll et al.   PSYCHOPHARMACOLOGY

Effects of age, but not sex, on elevated startle during withdrawal from acute morphine in adolescent and adult rats

(2015) Anna K. Radke et al.   BEHAVIOURAL PHARMACOLOGY

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model

(2015) Daniele Caprioli et al.   BIOLOGICAL PSYCHIATRY

Impact of an exercise intervention on methamphetamine use outcomes post-residential treatment care

(2015) Richard A. Rawson et al.   DRUG AND ALCOHOL DEPENDENCE

Does physical activity protect against drug abuse vulnerability?

(2015) Michael. T. Bardo et al.   DRUG AND ALCOHOL DEPENDENCE

Wheel running exercise attenuates vulnerability to self-administer nicotine in rats

(2015) Victoria Sanchez et al.   DRUG AND ALCOHOL DEPENDENCE

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

(2015) John R Mantsch et al.   NEUROPSYCHOPHARMACOLOGY

Increasing Progesterone Levels Are Associated With Smoking Abstinence Among Free-Cycling Women Smokers Who Receive Brief Pharmacotherapy

(2015) M. E. Saladin et al.   NICOTINE & TOBACCO RESEARCH

Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment

(2015) Catherine F. Moore et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Prevention of the incubation of cocaine seeking by aerobic exercise in female rats

(2015) Natalie E. Zlebnik et al.   PSYCHOPHARMACOLOGY

A Shift in the Role of Glutamatergic Signaling in the Nucleus Accumbens Core With the Development of an Addicted Phenotype

(2014) Susan E. Doyle et al.   BIOLOGICAL PSYCHIATRY

Effects of plasma allopregnanolone levels on drug craving in cocaine-dependent men and women

(2014) Verica Milivojevic et al.   DRUG AND ALCOHOL DEPENDENCE

Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: Treatment with allopregnanolone

(2014) Paul S. Regier et al.   DRUG AND ALCOHOL DEPENDENCE

Sex differences in the neurobiology of drug addiction

(2014) Samara A.M. Bobzean et al.   EXPERIMENTAL NEUROLOGY

Sex differences in addictive disorders

(2014) Liana Fattore et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sex differences in stress-related psychiatric disorders: Neurobiological perspectives

(2014) Debra A. Bangasser et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine

(2014) Damian G. Zuloaga et al.   JOURNAL OF NEUROCHEMISTRY

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Big data from small data: data-sharing in the 'long tail' of neuroscience

(2014) Adam R Ferguson et al.   NATURE NEUROSCIENCE

The CRH1 Antagonist GSK561679 Increases Human Fear But Not Anxiety as Assessed by Startle

(2014) Christian Grillon et al.   NEUROPSYCHOPHARMACOLOGY

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

(2014) Natalie E. Zlebnik et al.   PSYCHOPHARMACOLOGY

Estrous cycle and sex affect cocaine-induced behavioural changes in CD1 mice

(2014) Mariangela Martini et al.   PSYCHOPHARMACOLOGY

Effects of the combination of wheel running and atomoxetine on cue- and cocaine-primed reinstatement in rats selected for high or low impulsivity

(2014) Natalie E. Zlebnik et al.   PSYCHOPHARMACOLOGY

Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: impact of sex and estrous cycle in rats

(2014) Alexis B. Peterson et al.   PSYCHOPHARMACOLOGY

Sex differences in exercise and drug addiction: A mini review of animal studies

(2014) Yuehui Zhou et al.   Journal of Sport and Health Science

Combination pharmacotherapies for stimulant use disorder: a review of clinical findings and recommendations for future research

(2014) William W Stoops et al.   Expert Review of Clinical Pharmacology

Sex differences in impulsive action and impulsive choice

(2013) Jessica Weafer et al.   ADDICTIVE BEHAVIORS

Pair housing differentially affects motivation to self-administer cocaine in male and female rats

(2013) Christel Westenbroek et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic wheel running affects cocaine-induced c-Fos expression in brain reward areas in rats

(2013) Natalie E. Zlebnik et al.   BEHAVIOURAL BRAIN RESEARCH

Diminished Role of Dopamine D1-Receptor Signaling with the Development of an Addicted Phenotype in Rats

(2013) Carolina P. Ramôa et al.   BIOLOGICAL PSYCHIATRY

Substance-specific environmental influences on drug use and drug preference in animals and humans

(2013) Aldo Badiani   CURRENT OPINION IN NEUROBIOLOGY

Sex differences in the effects of estradiol in the nucleus accumbens and striatum on the response to cocaine: Neurochemistry and behavior

(2013) Jennifer A. Cummings et al.   DRUG AND ALCOHOL DEPENDENCE

Influence of Sex Differences and Gonadal Hormones on Cocaine Addiction

(2013) V. Quinones-Jenab et al.   ILAR JOURNAL

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

(2013) Taban Seif et al.   NATURE NEUROSCIENCE

Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control

(2013) Véronique Deroche-Gamonet et al.   NEUROPHARMACOLOGY

Subjective, Physiological and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

(2013) Elise E DeVito et al.   NEUROPSYCHOPHARMACOLOGY

Estradiol as a Mechanism for Sex Differences in the Development of an Addicted Phenotype following Extended Access Cocaine Self-Administration

(2013) Carolina P Ramôa et al.   NEUROPSYCHOPHARMACOLOGY

Adolescent alcohol exposure alters the rat adult hypothalamic–pituitary–adrenal axis responsiveness in a sex-specific manner

(2013) M.L. Logrip et al.   NEUROSCIENCE

Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: Effects of saccharin preference, impulsivity, and sex

(2013) Nathan A. Holtz et al.   PHYSIOLOGY & BEHAVIOR

The Development of a Preference for Cocaine over Food Identifies Individual Rats with Addiction-Like Behaviors

(2013) Adam N. Perry et al.   PLoS One

The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type

(2013) Helen C. Fox et al.   PSYCHONEUROENDOCRINOLOGY

Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase

(2013) Marilyn E. Carroll et al.   PSYCHOPHARMACOLOGY

Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal Model

(2013) D. Belin et al.   Cold Spring Harbor Perspectives in Medicine

Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders

(2013) Georgia E Hodes   Biology of Sex Differences

Sex differences in yohimbine-induced increases in the reinforcing efficacy of nicotine in adolescent rats

(2012) Sophia Li et al.   ADDICTION BIOLOGY

Association between ovarian hormones and smoking behavior in women.

(2012) Crystal Edler Schiller et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay

(2012) Laura L. Locklear et al.   NEUROPHARMACOLOGY

Sex Differences in Selecting Between Food and Cocaine Reinforcement are Mediated by Estrogen

(2012) Kerry A Kerstetter et al.   NEUROPSYCHOPHARMACOLOGY

Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor

(2012) D.L. Carbone et al.   NEUROSCIENCE

Brain-derived neurotrophic factor–estrogen interactions in the hippocampal mossy fiber pathway: Implications for normal brain function and disease

(2012) L.C. Harte-Hargrove et al.   NEUROSCIENCE

Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake

(2012) Nathan A. Holtz et al.   NEUROSCIENCE LETTERS

Sex differences in escalation of methamphetamine self-administration: cognitive and motivational consequences in rats

(2012) Carmela M. Reichel et al.   PSYCHOPHARMACOLOGY

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats

(2012) Natalie E. Zlebnik et al.   PSYCHOPHARMACOLOGY

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

(2012) Jill B Becker et al.   Biology of Sex Differences

Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies

(2012) Mark A. Smith et al.   Frontiers in Psychiatry

Different chronic ethanol exposure regimens in adolescent and adult male rats: Effects on tolerance to ethanol-induced motor impairment

(2011) Margaret Broadwater et al.   BEHAVIOURAL BRAIN RESEARCH

Cocaine Hydrolase Encoded in Viral Vector Blocks the Reinstatement of Cocaine Seeking in Rats for 6 Months

(2011) Justin J. Anker et al.   BIOLOGICAL PSYCHIATRY

Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone

(2011) Nathan A. Holtz et al.   DRUG AND ALCOHOL DEPENDENCE

Individual Variation in the Motivational Properties of Cocaine

(2011) Benjamin T Saunders et al.   NEUROPSYCHOPHARMACOLOGY

Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats

(2011) Deanne M. Buffalari et al.   PHYSIOLOGY & BEHAVIOR

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

(2011) N. A. Nasrallah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of individual and developmental differences in voluntary cocaine intake in rats

(2011) Nicole L. Schramm-Sapyta et al.   PSYCHOPHARMACOLOGY

Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model

(2011) Charles L. Pickens et al.   PSYCHOPHARMACOLOGY

Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differences

(2011) Justin J. Anker et al.   PSYCHOPHARMACOLOGY

Rewards, aversions and affect in adolescence: Emerging convergences across laboratory animal and human data

(2011) Linda Patia Spear   Developmental Cognitive Neuroscience

Gender Differences in Alcohol Treatment: An Analysis of Outcome From the COMBINE Study

(2010) Shelly F. Greenfield et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Motivation for Alcohol Becomes Resistant to Quinine Adulteration After 3 to 4 Months of Intermittent Alcohol Self-Administration

(2010) Frederic W. Hopf et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cocaine-induced neuroadaptations in glutamate transmission

(2010) Heath D. Schmidt et al.   Annals of the New York Academy of Sciences

Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion

(2010) Carolyn M. Mazure et al.   DRUG AND ALCOHOL DEPENDENCE

Reduced alcohol drinking in adult rats exposed to sucrose during adolescence

(2010) Leandro F. Vendruscolo et al.   NEUROPHARMACOLOGY

The paradox of drug taking: The role of the aversive effects of drugs

(2010) Anthony L. Riley   PHYSIOLOGY & BEHAVIOR

Prevention and treatment of drug addiction by environmental enrichment

(2010) Marcello Solinas et al.   PROGRESS IN NEUROBIOLOGY

Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers

(2010) Mehmet Sofuoglu et al.   PSYCHONEUROENDOCRINOLOGY

Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats

(2010) Natalie E. Zlebnik et al.   PSYCHOPHARMACOLOGY

Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats

(2010) Justin J. Anker et al.   PSYCHOPHARMACOLOGY

Effect of environmental enrichment on escalation of cocaine self-administration in rats

(2010) Cassandra D. Gipson et al.   PSYCHOPHARMACOLOGY

Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats

(2010) Friemel   Frontiers in Behavioral Neuroscience

Reduced alcohol consumption in mice with access to a running wheel

(2009) Marissa A. Ehringer et al.   ALCOHOL

Gender differences in delay-discounting under mild food restriction

(2009) Susanne Koot et al.   BEHAVIOURAL BRAIN RESEARCH

Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake

(2009) Justin J. Anker et al.   BEHAVIOURAL PHARMACOLOGY

Sex and cannabinoid CB1 genotype differentiate palatable food and cocaine self-administration behaviors in mice

(2009) Sara Jane Ward et al.   BEHAVIOURAL PHARMACOLOGY

Does the response to cocaine differ as a function of sex or hormonal status in human and non-human primates?

(2009) Suzette M. Evans et al.   HORMONES AND BEHAVIOR

Sex differences and ovarian hormones in animal models of drug dependence

(2009) Marilyn E. Carroll et al.   HORMONES AND BEHAVIOR

Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of naturally cycling and ovariectomized rats

(2009) Danielle C. Llaneza et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neurobehavioral effects of environmental enrichment and drug abuse vulnerability

(2009) Dustin J. Stairs et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Impulsivity, frontal lobes and risk for addiction

(2009) Fulton Timm Crews et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Long-term risk preference and suboptimal decision making following adolescent alcohol use

(2009) N. A. Nasrallah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in the self-administration of cannabinoids and other drugs of abuse

(2009) Liana Fattore et al.   PSYCHONEUROENDOCRINOLOGY

Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats

(2009) Justin J. Anker et al.   PSYCHOPHARMACOLOGY

Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys

(2009) Marilyn E. Carroll et al.   PSYCHOPHARMACOLOGY

Menstrual phase effects on smoking relapse

(2008) Sharon S. Allen et al.   ADDICTION

Influence of phase-related variability in premenstrual symptomatology, mood, smoking withdrawal, and smoking behavior during ad libitum smoking, on smoking cessation outcome

(2008) Sharon S. Allen et al.   ADDICTIVE BEHAVIORS

Gender and Age at Drinking Onset Affect Voluntary Alcohol Consumption but Neither the Alcohol Deprivation Effect nor the Response to Stress in Mice

(2008) Sophie Tambour et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Menstrual Phase Effects on Smoking Cessation: A Pilot Feasibility Study

(2008) Matthew J. Carpenter et al.   JOURNAL OF WOMENS HEALTH

Menstrual Cycle Phase at Quit Date Predicts Smoking Status in an NRT Treatment Trial: A Retrospective Analysis

(2008) Teresa R. Franklin et al.   JOURNAL OF WOMENS HEALTH

Age-related differences in the blood alcohol levels of Wistar rats

(2008) Brendan M. Walker et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Context-induced relapse to drug seeking: a review

(2008) H. S Crombag et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Attenuation of cocaine-seeking by progesterone treatment in female rats

(2008) Matthew W. Feltenstein et al.   PSYCHONEUROENDOCRINOLOGY

The role of impulsive behavior in drug abuse

(2008) Jennifer L. Perry et al.   PSYCHOPHARMACOLOGY

Protracted time-dependent increases in cocaine-seeking behavior during cocaine withdrawal in female relative to male rats

(2008) Kerry A. Kerstetter et al.   PSYCHOPHARMACOLOGY

Sex differences in drug abuse

(2007) Jill B. Becker et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers

(2007) C. Anderson Johnson et al.   NEUROPSYCHOLOGIA