The CRH1 Antagonist GSK561679 Increases Human Fear But Not Anxiety as Assessed by Startle

Corticotropin releasing factor: A key role in the neurobiology of addiction

(2014) Eric P. Zorrilla et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Evaluation of a corticotropin releasing hormone type 1 receptor antagonist in women with posttraumatic stress disorder: study protocol for a randomized controlled trial

(2014) Boadie W Dunlop et al.   Trials

Neuronal correlates of fear conditioning in the bed nucleus of the stria terminalis

(2013) D. Haufler et al.   LEARNING & MEMORY

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population

(2012) Yoshinobu Ishitobi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety

(2012) K S Sink et al.   MOLECULAR PSYCHIATRY

Oxytocin increases anxiety to unpredictable threat

(2012) C Grillon et al.   MOLECULAR PSYCHIATRY

Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test)

(2012) Anja Schmitz et al.   Nature Protocols

Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?

(2012) Guy Griebel et al.   NATURE REVIEWS DRUG DISCOVERY

Acute Hydrocortisone Treatment Increases Anxiety but Not Fear in Healthy Volunteers: A Fear-Potentiated Startle Study

(2011) Christian Grillon et al.   BIOLOGICAL PSYCHIATRY

Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety

(2011) Jayne E Bailey et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Update on Corticotropin-Releasing Factor Pharmacotherapy for Psychiatric Disorders: A Revisionist View

(2011) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

(2011) D. Refojo et al.   SCIENCE

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties

(2010) John E. Tellew et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

(2010) Vladimir Coric et al.   DEPRESSION AND ANXIETY

Local repeated corticotropin-releasing factor infusion exacerbates anxiety- and fear-related behavior: differential involvement of the basolateral amygdala and medial prefrontal cortex

(2010) E.Y. Bijlsma et al.   NEUROSCIENCE

Increased Anxiety During Anticipation of Unpredictable Aversive Stimuli in Posttraumatic Stress Disorder but not in Generalized Anxiety Disorder

(2009) Christian Grillon et al.   BIOLOGICAL PSYCHIATRY

Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans

(2009) F. Klumpers et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

(2009) Michael Davis et al.   NEUROPSYCHOPHARMACOLOGY

Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses

(2009) D.L. Walker et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder

(2008) Martin E. Keck et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Increased Anxiety During Anticipation of Unpredictable But Not Predictable Aversive Stimuli as a Psychophysiologic Marker of Panic Disorder

(2008) Christian Grillon et al.   AMERICAN JOURNAL OF PSYCHIATRY

A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH1Antagonist) in the Treatment of Major Depression

(2008) Brendon Binneman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Central CRH system in depression and anxiety — Evidence from clinical studies with CRH1 receptor antagonists

(2008) Florian Holsboer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists

(2008) Romano Di Fabio et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Role for Brain Stress Systems in Addiction

(2008) George F. Koob   NEURON

Differential Effects of the CRF-R1 Antagonist GSK876008 on Fear-Potentiated, Light- and CRF-Enhanced Startle Suggest Preferential Involvement in Sustained vs Phasic Threat Responses

(2008) David Walker et al.   NEUROPSYCHOPHARMACOLOGY

Two-Week Treatment With the Selective Serotonin Reuptake Inhibitor Citalopram Reduces Contextual Anxiety but Not Cued Fear in Healthy Volunteers: A Fear-Potentiated Startle Study

(2008) Christian Grillon et al.   NEUROPSYCHOPHARMACOLOGY