Article
Nanoscience & Nanotechnology
Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y. Henry Sun, Joseph Jen-Tse Huang
Summary: The researchers designed and synthesized a polyglutamine-specific gold nanoparticle complex that targeted mHtt and alleviated its toxicity. The complex was able to disassociate fibrillary aggregates from polyQ peptides and reduce beta-sheet content in a concentration-dependent manner. Additionally, the complex was shown to penetrate cells, bind to cytosolic mHtt proteins, dissociate mHtt inclusions, reduce mHtt oligomers, and ameliorate mHtt-induced toxicity, suggesting potential therapeutic strategies against Huntington's disease.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nutrition & Dietetics
Yan-Xi Chen, Phuong Thu Nguyen Le, Tsai-Teng Tzeng, Thu-Ha Tran, Anh Thuc Nguyen, Irene Han-Juo Cheng, Chi-Ying F. Huang, Young-Ji Shiao, Tsui-Ting Ching
Summary: The GP extract has been shown to inhibit the growth of liver cancer cells, reduce pathological phenotypes of Alzheimer's disease, suppress beta-amyloid pathology, enhance AMPK activity, and improve autophagy in various cell lines and animal models, ultimately extending lifespan.
Article
Neurosciences
Zhen-Yu Li, Li-Hua Chen, Xiu-Yun Zhao, Hong Chen, Yan-Yun Sun, Mei-Hong Lu, Zhao-Tao Wang, Mei Chen, Li Lu, Wenhui Huang, Rui Chen, De-En Xu, Ru-Xiang Xu, Quan-Hong Ma
Summary: The study demonstrates that clemastine can alleviate Alzheimer's disease pathology in APP/PS1 transgenic mice, including reducing amyloid-beta load, neuroinflammation, and cognitive deficits. Clemastine reduces Aβ generation by decreasing levels of BACE1, APP CTFs, while enhancing autophagy and suppressing the mTOR signaling pathway.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cell Biology
Maxinne Watchon, Luan Luu, Stuart K. Plenderleith, Kristy C. Yuan, Angela S. Laird
Summary: This study found impaired autophagy protein quality control pathway in cell culture and zebrafish models of SCA3. Treatment with autophagy-inducing compounds improved the swimming ability of SCA3 zebrafish, suggesting the potential benefit of such compounds for SCA3 treatment.
Review
Pharmacology & Pharmacy
Wei Zhang, Chengchao Xu, Jichao Sun, Han-Ming Shen, Jigang Wang, Chuanbin Yang
Summary: Alzheimer's disease is a common neurodegenerative disorder characterized by memory loss and cognitive dysfunction. Impaired autophagy-lysosomal pathway is linked to AD pathogenesis, and enhancing autophagy to remove protein aggregates is proposed as a promising therapeutic strategy.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Physiology
Camilla Ferrari, Sandro Sorbi
Summary: The history of Alzheimer's disease dates back to 1907, but it wasn't until the end of the century that the components of pathological hallmarks and genetic subtypes were identified, leading to the first pathogenic hypothesis. Advances in biomarkers and technology have shifted the concept of AD from a static view to a biological entity that can manifest in various ways. Research shows that AD is heterogeneous in terms of amyloid composition, tau distribution, clinical symptoms, and genetic background, making it difficult to explain with a single pathological process.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Tsz Yan Fung, Ashok Iyaswamy, Sravan G. Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, Hoi Leong Xavier Wong, Min Li
Summary: This article reviews the role of Klotho in Alzheimer's disease (AD), including its effect on promoting amyloid-beta clearance and inducing autophagy for the clearance of toxic proteins through regulating the autophagy lysosomal pathway. The results of multiple studies suggest that targeting Klotho could be a potential therapeutic strategy in AD treatment.
Review
Biochemistry & Molecular Biology
Aleksandra S. Churkina (Taran), Anton S. Shakhov, Anatoly A. Kotlobay, Irina B. Alieva
Summary: Neurodegenerative diseases cannot be cured, but they share similar cellular pathologies. This offers hope for finding common intracellular targets and universal treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Leo Kit Cheung Lee, Lok Leong, Yao Liu, Meihua Luo, Ho Yin Edwin Chan, Chung Hang Jonathan Choi
Summary: Polyglutamine diseases are inheritable progressive neurodegenerative disorders lacking disease-modifying therapeutic interventions. Nanoparticles offer potential for improved drug delivery to the brain, with promising preclinical applications in treating polyQ diseases. The future of nanomedicines for polyQ diseases appears promising with developments in inorganic nanoparticles and novel drug candidates.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biophysics
Sharon E. Groover, Adewale Adegbuyiro, Caleb K. Fan, Breanna L. Hodges, Maryssa Beasley, Katelyn Taylor, Alyssa R. Stonebraker, Chathuranga Siriwardhana, Justin Legleiter
Summary: This study investigated the impact of macromolecular crowding on the aggregation of Huntington's disease-related protein htt in bulk solution and at interfaces. It was found that crowding agents influenced the aggregation characteristics of htt on different interfaces, highlighting the importance of crowding in the aqueous phase on this process.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Cameron Wells, Samuel Brennan, Matt Keon, Lezanne Ooi
Summary: Neurodegenerative diseases such as AD, PD, HD, and ALS are rooted in the activities of amyloid-like proteins, with monomeric proteins undergoing conformational shifts to facilitate aggregation and formation of solid fibrils. Oligomeric stages are key drivers of neuronal toxicity, and feedback within the pathway results in exponential acceleration of aggregation. The complex protein dynamics contribute to the late onset and accelerating progression of these disorders, affecting cellular interactions and environment. Targeting core elements of pathological progression may hold promise for future therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Yapei Jiang, Naihan Xu
Summary: Neurodegenerative diseases are a major global health problem, and identifying molecular markers related to neurodegenerative processes is urgently important. Defects in autophagy, the process of removing aggregate-prone proteins in neurons, are often associated with the development of neurodegenerative diseases. Aberrant regulation of long non-coding RNAs (lncRNAs) also plays a role in neurological disorders. This review summarizes the recent progress in studying lncRNAs and autophagy in the context of neurodegenerative disorders, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), providing guidance for future research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Srinivasa Reddy Bonam, Christine Tranchant, Sylviane Muller
Summary: Cellular quality control systems, particularly autophagy, play a crucial role in cell survival and maintaining homeostasis. Different types of autophagy pathways show varying degrees of selectivity towards substrates. In neurodegenerative diseases, such as Parkinson's disease, autophagy is important and therapeutic strategies targeting autophagy may alter disease progression.
Review
Biochemistry & Molecular Biology
Ricardo Moreira, Liliana S. Mendonca, Luis Pereira de Almeida
Summary: Recent research has shown that disease-causing proteins can spread from one focal point to other regions in the brain through extracellular vesicles. These vesicles, carrying pathological molecules, may trigger pathological pathways when internalized by healthy cells, ultimately promoting disease spread to neighboring cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Nicholas Andrikopoulos, Huayuan Tang, Yue Wang, Xiufang Liang, Yuhuan Li, Thomas P. Davis, Pu Chun Ke
Summary: Therapeutic peptides are important drugs that specifically target abnormal protein-protein interactions associated with amyloid diseases. The use of nanoparticles in combination with peptide drugs has emerged as a promising strategy for enhancing their efficacy against amyloid aggregation and cellular inflammation. However, there is still a lack of understanding of the chemistry and function of peptido-nanocomposites, and a systematic analysis of their application against a range of amyloid pathogeneses is missing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Ankan Kumar Sarkar, Koushik Debnath, Himali Arora, Pankaj Seth, Nihar R. Jana, Nikhil R. Jana
Summary: The direct cytosolic delivery of large biomolecules bypassing endocytic pathways is a promising strategy for therapeutic applications. Recent research has shown that surface chemistry of carriers, nanoscale assembly, colloidal stability, and low surface charge are critical for non-endocytic uptake processes. The guanidinium-terminated polyaspartic acid micelle can deliver protein/DNA directly to the cytosol by forming a nano-assembly with <200 nm size and near-zero surface charge, highlighting the importance of size and colloidal properties for efficient cytosolic delivery of large biomolecules.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Santu Ghosh, Anupam Maity, Nikhil R. Jana
Summary: Piezoelectric nanomaterials can be used for water purification by utilizing ultrasound or water/air flow for degradation of toxic organics and bacterial disinfection through the generation of reactive oxygen species at the piezoelectric nanoparticle surface. However, the coupling of highly piezoelectric materials with appropriate water purification platforms is still not well explored. This study introduces a highly piezoelectric material-based composite coupled with a commercially available ultrasound platform for effective water purification, offering a promising alternative approach.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Reeddhi Ray, Santu Ghosh, Prasanta Panja, Nikhil R. Jana
Summary: Although mitochondria have been recognized as a potential therapeutic target, inefficient drug targeting limits their therapeutic applications. In this study, a designed nanoprobe with arginine/guanidinium terminated surface was developed for nonendocytic mitochondria targeting. The nanoprobe demonstrated efficient penetration and specific labeling of mitochondria within 1 hour, providing a promising strategy for mitochondria delivery of drugs.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Suman Mandal, Debabrata Jana, Jayanta Dolai, Ankan Kumar Sarkar, Binay K. Ghorai, Nikhil R. Jana
Summary: Trehalose-conjugated polycarbonate-co-lactide nanoparticles have the ability to inhibit protein aggregation and activate cellular autophagy, making them a potential treatment for neurodegenerative diseases.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Ankan Kumar Sarkar, Santanu Shaw, Himali Arora, Pankaj Seth, Nikhil R. R. Jana
Summary: Subcellular targeting of drugs can be enhanced by designing nanocarriers for direct cell membrane translocation, bypassing endosomal/lysosomal trafficking. This approach allows rapid and extensive delivery of drugs to the cell nucleus within a few minutes, without undergoing vesicular coating and lysosomal trafficking. This nonendocytic uptake method provides a potential strategy for nanocarrier-based subcellular targeting of drugs for more effective therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Jayanta Dolai, Abu Raihan Sarkar, Sampad Das, Nikhil Ranjan Jana
Summary: Ultrasound-assisted ROS generation from piezoelectric nanomaterial provides a unique wireless therapeutic approach in remote areas. BaTiO3-Au nanorods were synthesized to enhance the piezoelectric performance for diverse applications. The functionalized nanohybrid with folate can selectively target folate-overexpressed cancer cells and generate intracellular ROS under ultrasound exposure for wireless cell therapy.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2023)
Article
Nanoscience & Nanotechnology
Santanu Shaw, Ankan Kumar Sarkar, Nikhil R. Jana
Summary: This study presents a novel nonendocytic cell uptake approach for protein delivery to the cell nucleus. By designing a specific micellar carrier that can bind with protein in the presence of green tea polyphenol, it is possible to deliver proteins to the cytosol and even to the nucleus.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Nanoscience & Nanotechnology
Abu Raihan Sarkar, Nikhil R. Jana
Summary: Ultrasound-based sonodynamic therapy using sound-responsive materials has great potential for the wireless treatment of human diseases. This study investigated the ROS generation performance of molecular sonosensitizer-loaded polymer micelles under ultrasound, and found that singlet oxygen is the primary ROS component. The ROS generation performance depends on the molecular structure and experimental conditions. Additionally, the use of nanomicelle-based carriers greatly improves the therapeutic performance of sonodynamic therapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Abu Raihan Sarkar, Suman Pal, Ankan Kumar Sarkar, Nikhil R. Jana
Summary: A colloidal nanoparticle form of hemin with intact catalytic performance and high cellular uptake properties is reported in this study. The designed nanoparticles can enter cells, generate oxidative stress, and induce autophagy.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Roobala Chelladurai, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: Lipid nanotubules (LNTs) are conduits formed on cell and organelle membranes, present in all forms of life. The formation and dynamics of these tubes are crucial for cellular functions and are believed to play a role in pathogenic spread of diseases. By binding synthetic nanoparticles on supported lipid bilayers, the formation of LNTs can be controlled, aiding in disease control and therapy.
Article
Chemistry, Physical
Aritra Biswas, Uddalok Kar, Nikhil R. Jana
Summary: The cytotoxicity of zinc oxide nanoparticles is directly related to the generation of reactive oxygen species (ROS) through oxygen vacancy defects. The designed nanoparticles have potential applications in cell therapy and antibacterial materials.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Koushik Debnath, Ankan Kumar Sarkar, Nihar R. Jana, Nikhil R. Jana
Summary: Protein aggregation is associated with various human diseases, and research is focused on understanding the mechanisms of protein aggregation, cytotoxicity of protein aggregates, and developing drugs for these diseases. Antiamyloidogenic materials such as small molecules and nanomaterials have shown potential in inhibiting protein aggregation and improving drug performance, but further improvements are needed for effective drug development strategies.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
