Article
Polymer Science
Jing Kang, Fei-Zheng Wu, Yao Xue, Zhi-Han Li, Yu-Xi Wang, Kun Liu
Summary: PEGylation is the most effective method for surface modification of gold nanoparticles, but the stability of PEG ligands is an issue. Reactive oxygen species are found to be a major factor causing the detachment of PEG ligands. By using dopamine-functionalized PEG to modify the gold nanoparticles, their stability and antifouling ability can be improved, allowing for control of self-assembly with serum proteins.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Review
Biochemistry & Molecular Biology
Suneel Kumar, Thomas Theis, Monica Tschang, Vini Nagaraj, Francois Berthiaume
Summary: Traumatic injuries to the nervous system, such as spinal cord injury and brain injury, can result in neurological dysfunction, causing patients to be bed-ridden and immobile for extended periods. Secondary complications like bladder/bowel dysfunction and pressure ulcers can lead to further debilitating conditions.
Article
Nanoscience & Nanotechnology
Hsin-Lun Lee, Yao Chen Chuang, Jo-Ting Tsai, Yu-Chen Chen, Ping-Hsiu Wu, Leu-Wei Lo, Jeng-Fong Chiou, Yao-An Shen
Summary: Gold nanomaterials have gained attention in biomedical applications due to their biocompatibility and unique properties. In this study, a gold nanodandelion-based system for scavenging reactive oxygen species (ROS) was developed. The system showed excellent antioxidant properties and could mitigate oxidative stress. The size and surface characteristics of the gold nanomaterials influenced their efficiency in scavenging ROS.
ACS APPLIED NANO MATERIALS
(2023)
Article
Andrology
Agnes Hajnal, Noemi Bogdandi, Judit Marokhazi, Dorina Guba, Endre G. Mikus
Summary: The study aims to provide a reliable method for diagnosing oxidative stress caused by male urogenital inflammation. Seminal cell-specific fluorescence intensity of oxidative stress can differentiate leukocytospermic samples with excessive reactive oxygen species from normozoospermic samples. Results showed that both spermatozoa and leukocytes in leukocytospermic samples had higher oxidative stress-related fluorescence intensity compared to normozoospermic samples. The study suggests that leukocyte-generated oxidative stress may be the main source of oxidative stress in semen.
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Oncology
Nada S. Aboelella, Caitlin Brandle, Timothy Kim, Zhi-Chun Ding, Gang Zhou
Summary: It is well-established that cancer cells are constantly under oxidative stress due to increased metabolism from aberrant growth, leading to elevated levels of reactive oxygen species (ROS). There is a prevalent perception that ROS play a crucial role in promoting tumor initiation, progression, metastasis, and drug resistance. Recent advances suggest that cancer immunotherapies can alter tumor redox to intensify oxidative stress, resulting in enhanced antitumor effects.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hyunjun Choi, Bongseo Choi, Jun-Hyeok Han, Ha Eun Shin, Wooram Park, Dong-Hyun Kim
Summary: A ROS-responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported, which shows significant structural deformation in the presence of ROS and demonstrates potential in cancer treatment and other biomedical applications.
Review
Chemistry, Analytical
Yong Zhang, Chunyu Zhang, Chao Xu, Xiaolin Wang, Chang Liu, Geoffrey I. N. Waterhouse, Yaling Wang, Hongzong Yin
Article
Chemistry, Multidisciplinary
Chunyu Zhang, Liang Gao, Qing Yuan, Lina Zhao, Wenchao Niu, Pengju Cai, Jiaojiao Li, Xu Han, Zhesheng He, Fuping Gao, Yaling Wang, Huaidong Jiang, Zhifang Chai, Xueyun Gao
Article
Chemistry, Analytical
Chunyu Zhang, Shengkun Yao, Chao Xu, Yanan Chang, Yunbing Zong, Kai Zhang, Xiangzhi Zhang, Lijuan Zhang, Chunying Chen, Yuliang Zhao, Huaidong Jiang, Xueyun Gao, Yaling Wang
Summary: The development of three-dimensional single-cell imaging and protein quantitative methods has provided more comprehensive information for diagnoses. A multisignal nanoprobe was designed and synthesized for single-cell 3D imaging and quantifying the integrin alpha(IIb)beta(3) using synchrotron radiation soft X-ray tomography microscopy and an iterative tomographic algorithm for the first time. Additionally, the number of integrin alpha(IIb)beta(3) on a single cell can be accurately quantified based on the Au or Gd content of the nanoprobe through inductively coupled plasma mass spectrometry.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiaojiao Li, Xiangchun Zhang, Fuping Gao, Qing Yuan, Chunyu Zhang, Hui Yuan, Yanhong Liu, Lu Chen, Ying Han, Xueyun Gao, Liang Gao
Summary: A novel method for detecting low-abundance protein biomarkers associated with tumor progression has been developed using clusterbodies with integrated features, providing more precise and sensitive results compared to traditional antibodies. The method has been found to have an extremely low detection limit, aiding in the more accurate assessment of tumor malignancy and invasion capability.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiaojiao Li, Zijing Lai, Han Li, Wenchao Niu, Zhongying Du, Ying Han, Lu Chen, Chunyu Zhang, Yuhua Tang, Haolin Zou, Xueyun Gao, Liang Gao
Summary: We have developed a peptide-conjugated metal cluster probe for quantitative analysis of a membrane protein biomarker and detection of epithelial-to-mesenchymal transition in tumor cells. This probe, called clusterzyme, has selective recognition and enzyme-like activity, allowing sensitive analysis of the membrane protein on cells. This method is compatible with traditional enzyme-linked immunosorbent assays and offers improved detection sensitivity and accuracy. The expression level of the membrane protein reflects the migration and invasion ability of tumor cells, revealing the epithelial-to-mesenchymal transition process. This work provides a simple and sensitive approach to monitor tumor cell type evolution at the molecular level, with potential applications in early cancer diagnosis and therapy assessment.
ANALYTICAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Chunyu Zhang, Chao Xu, Xueyun Gao, Qingqiang Yao
Summary: This article discusses the application and development of platinum-based drugs in cancer treatment, particularly the targeted modification of platinum nanoclusters. The new platinum drugs provide a promising prospect for improving anti-cancer treatments.
Article
Nanoscience & Nanotechnology
Guihua Zhou, Wencong Zhao, Chunyu Zhang, Xueyun Gao, Qingli Cheng, Fuping Gao
Summary: Acute kidney injury (AKI) is a common condition in hospitalized patients with limited treatment options. This study developed a H2O2-responsive nanomedicine for CO therapy of AKI using manganese carbonyl loaded onto hollow mesoporous silicon nanoparticles coated with a neutrophil membrane. The nanomedicine demonstrated protective effects against oxidative damage of renal tubular cells in vitro and glycerol-induced AKI in vivo, offering promise for the treatment of AKI.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhesheng He, Fei Ye, Chunyu Zhang, Jiadong Fan, Zhongying Du, Wencong Zhao, Qing Yuan, Wenchao Niu, Fuping Gao, Bo He, Peng Cao, Lina Zhao, Xuejiao Gao, Xingfa Gao, Bo Sun, Yuhui Dong, Jincun Zhao, Jianxun Qi, Xing-Jie Liang, Huaidong Jiang, Yong Gong, Wenjie Tan, Xueyun Gao
Summary: Gold clusters show better therapeutic outcomes in COVID-19 treatment than Remdesivir, as they directly inhibit viral replication and suppress inflammatory cytokine expression.
Article
Chemistry, Multidisciplinary
Xu Han, Zhesheng He, Wenchao Niu, Chunyu Zhang, Zhongying Du, Xueyun Gao, Gengmei Xing
Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with no effective targeted therapy available. Accurate quantification of HER-2 expression in breast cancer cells is important for diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Wenchao Niu, Zhongying Du, Chunyu Zhang, Deting Xu, Jiaojiao Li, Minghui Sun, Liyuan Wu, Haodong Yao, Lina Zhao, Xueyun Gao
Summary: The study reveals that gold clusters can inhibit the activity of TrxR1 in tumor cells by interacting with the Cys189 site in TrxR1, disrupting the electron transfer pathway between TrxR1 and Trx.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Chunyu Zhang, Kai Zhang, Yanyan Cui, Yuecong Guo, Chuan Wang, Chao Xu, Qingqiang Yao, Yuliang Zhao, Chunying Chen, Yaling Wang
Summary: In this study, a multifunctional nanoprobe was designed to achieve three-dimensional localization of proteins in large, thick cells using synchrotron radiation hard X-ray imaging. The results showed that the HER2 protein was mainly distributed on the cell membrane with a heterogeneous pattern. This study provides a new method for non-destructive evaluation of the distribution of nanoprobes in cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dongfang Xia, Yong Zhang, Chunyu Zhang, Xiuxiu Yao, Yuhua Tang, Fuchao Wang, Xu Han, Hongzong Yin, Chao Xu, Xueyun Gao
Summary: Alpha (v) beta (3) is overexpressed in tumor cells and plays a key role in tumor progression. Detecting its levels accurately is significant. A peptide-coated platinum cluster provides a reliable method to evaluate alpha (v) beta (3) levels in cells through various techniques. By binding to the receptor, the Pt cluster catalyzes color change, enabling visual detection of alpha (v) beta (3) expression levels in living cells and differentiation of cell lines with different expression levels.
FRONTIERS IN CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Pengju Cai, Dongdong Su, Wenjiang Yang, Zhesheng He, Chunyu Zhang, Hui Liu, Zhibo Liu, Xiangchun Zhang, Liang Gao, Yu Liu, Huaidong Jiang, Fuping Gao, Xueyun Gao
ACS APPLIED BIO MATERIALS
(2020)
Article
Medicine, Research & Experimental
Zhichao Zhang, Yawen Yao, Qing Yuan, Cao Lu, Xiangchun Zhang, Jinling Yuan, Kaixiao Hou, Chunyu Zhang, Zhongying Du, Xueyun Gao, Xiongsheng Chen