Effect of CXCR2 Inhibition on Behavioral Outcomes and Pathology in Rat Model of Neuromyelitis Optica

The contribution of neutrophils to CNS autoimmunity

(2018) Emily R. Pierson et al.   CLINICAL IMMUNOLOGY

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

(2017) Jane A. Lindborg et al.   JOURNAL OF NEUROSCIENCE

Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair

(2017) Hal X. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Increased plasma levels of epithelial neutrophil-activating peptide 78/CXCL5 during the remission of Neuromyelitis optica

(2016) Tao Yang et al.   BMC Neurology

Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders

(2016) Heng Xu et al.   ACS Medicinal Chemistry Letters

The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model

(2015) Christian Geis et al.   EXPERIMENTAL NEUROLOGY

CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation

(2015) Fengjiao Wu et al.   Journal of Neuroinflammation

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

(2015) Laura Hertwig et al.   Multiple Sclerosis Journal

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

(2015) Laura Hertwig et al.   Multiple Sclerosis Journal

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

(2015) Kazuhiro Kurosawa et al.   Acta Neuropathologica Communications

Blockade of CXCR2 signalling: A potential therapeutic target for preventing neutrophil-mediated inflammatory diseases

(2014) Nithin B Boppana et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions

(2014) B. F. G. Popescu et al.   NEUROLOGY

Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms – A pilot study

(2013) B.D. Michael et al.   CYTOKINE

Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Accelerated axon loss in MOG35-55 experimental autoimmune encephalomyelitis (EAE) in myelin-associated glycoprotein-deficient (MAGKO) mice

(2013) Melina V. Jones et al.   JOURNAL OF NEUROIMMUNOLOGY

Myelin Repair Is Accelerated by Inactivating CXCR2 on Nonhematopoietic Cells

(2013) L. Liu et al.   JOURNAL OF NEUROSCIENCE

Chemokine receptor CXCR2: Physiology regulator and neuroinflammation controller?

(2012) Mike Veenstra et al.   JOURNAL OF NEUROIMMUNOLOGY

Review of animal models of neuromyelitis optica

(2012) Melina V. Jones et al.   Multiple Sclerosis and Related Disorders

Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

(2011) Samira Saadoun et al.   ANNALS OF NEUROLOGY

Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells

(2010) Makoto Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A common intracellular allosteric binding site for antagonists of the CXCR2 receptor

(2010) K Salchow et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

(2010) LiPing Liu et al.   NATURE NEUROSCIENCE

CXCR2 Signaling Protects Oligodendrocytes and Restricts Demyelination in a Mouse Model of Viral-Induced Demyelination

(2010) Martin P. Hosking et al.   PLoS One

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Neuromyelitis optica: Passive transfer to rats by human immunoglobulin

(2009) Makoto Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: An in vitro study

(2009) Lidia Sabater et al.   JOURNAL OF NEUROIMMUNOLOGY

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

(2008) Geraldine Parenty et al.   BIOCHEMICAL JOURNAL

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR2 antagonists for the treatment of pulmonary disease

(2008) R.W. Chapman et al.   PHARMACOLOGY & THERAPEUTICS