Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus

Anti-fibrotic cardioprotection of berberine via down-regulating myocardial IGF-1 receptor-regulated MMP-2/9 expression in diabetic rats

(2018) Guohua Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress‐Mediated Atrial Remodeling in Alloxan‐Induced Diabetes Mellitus Rabbits

(2018) Yajuan Yang et al.   Journal of the American Heart Association

Mitochondrial‐Mediated Oxidative Ca 2+ /Calmodulin‐Dependent Kinase II Activation Induces Early Afterdepolarizations in Guinea Pig Cardiomyocytes: An In Silico Study

(2018) Ruilin Yang et al.   Journal of the American Heart Association

Hawthorn Leaf Flavonoids Protect against Diabetes-Induced Cardiomyopathy in Rats via PKC-α Signaling Pathway

(2017) Qing Min et al.   Evidence-based Complementary and Alternative Medicine

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMKII oxidation causes increased atrial fibrillation in diabetic mice

(2017) Olurotimi Mesubi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation

(2017) Cui Chen et al.   Experimental and Therapeutic Medicine

Alogliptin, a Dipeptidyl Peptidase‐4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits

(2017) Xiaowei Zhang et al.   Journal of the American Heart Association

Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation

(2017) Niloy Bhattacharjee et al.   Frontiers in Pharmacology

Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis

(2016) Aaron R. Froese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway

(2016) Yuan Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice

(2016) Han Wu et al.   BMC Cardiovascular Disorders

Urocortin attenuates myocardial fibrosis in diabetic rats via the Akt/GSK-3β signaling pathway

(2016) Xinyu Liu et al.   ENDOCRINE RESEARCH

Depletion of T lymphocytes ameliorates cardiac fibrosis in streptozotocin-induced diabetic cardiomyopathy

(2016) Chowdhury S. Abdullah et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Reactive oxygen species-mediated cardiac-reperfusion injury: Mechanisms and therapies

(2016) Fereshte Bagheri et al.   LIFE SCIENCES

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

(2016) Euy‐Myoung Jeong et al.   Journal of the American Heart Association

Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study

(2015) Qince Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase

(2015) J. Roussel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sudden cardiac death in patients with diabetes mellitus and chronic heart failure

(2015) Andrew MN Walker et al.   Diabetes & Vascular Disease Research

Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation

(2015) Cynthia Dayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

(2015) Tetsuro Oda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

(2014) Antoinette Bugyei-Twum et al.   Cardiovascular Diabetology

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

(2014) Ting Liu et al.   CIRCULATION RESEARCH

Effects of Regional Mitochondrial Depolarization on Electrical Propagation

(2014) Lufang Zhou et al.   Circulation-Arrhythmia and Electrophysiology

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

(2014) Konstantinos Palikaras et al.   EXPERIMENTAL GERONTOLOGY

Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling

(2014) Nannan Shen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats

(2014) Pabitra Bikash Pal et al.   PLoS One

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

(2014) Quan Liu et al.   Journal of Diabetes Investigation

Alterations in connexin 43 during diabetic cardiomyopathy: Competition of tyrosine nitration versus phosphorylation 在糖尿病心肌病中间隙连接蛋白43的变化：酪氨酸硝化作用与磷酸化作用的竞争

(2014) Mandar S. Joshi et al.   Journal of Diabetes

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs

(2013) Chaoqin Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII

(2013) Can M. Sag et al.   BASIC RESEARCH IN CARDIOLOGY

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

(2013) Hsiang-Ting Ho et al.   CARDIOVASCULAR RESEARCH

Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure

(2013) Mohamed Ameen Ismahil et al.   CIRCULATION RESEARCH

Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis

(2013) Zhichao Yue et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

(2013) Min Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibrosis and arrhythmogenesis: The road to repair is paved with perils

(2013) Thao P. Nguyen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac mitochondrial network excitability: insights from computational analysis

(2012) Lufang Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Conduction and refractory disorders in the diabetic atrium

(2012) Masaya Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox Regulation of Sodium and Calcium Handling

(2012) Stefan Wagner et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipid-Induced Insulin Resistance Is Not Mediated by Impaired Transcapillary Transport of Insulin and Glucose in Humans

(2012) J. Szendroedi et al.   DIABETES

Oxidative and nitrosative stress in the maintenance of myocardial function

(2012) Yixuan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Endothelial–mesenchymal transition and its contribution to the emergence of stem cell phenotype

(2012) Damian Medici et al.   SEMINARS IN CANCER BIOLOGY

Meta-Analysis of Cohort and Case–Control Studies of Type 2 Diabetes Mellitus and Risk of Atrial Fibrillation

(2011) Rachel R. Huxley et al.   AMERICAN JOURNAL OF CARDIOLOGY

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Uncoupling Protein 3 (UCP3) Modulates the Activity of Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) by Decreasing Mitochondrial ATP Production

(2011) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized CaMKII: a “heart stopper” for the sinus node?

(2011) Sabine Huke et al.   JOURNAL OF CLINICAL INVESTIGATION

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress

(2011) Lufang Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolic stress, reactive oxygen species, and arrhythmia

(2011) Euy-Myoung Jeong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Suppression of Re-Entrant and Multifocal Ventricular Fibrillation by the Late Sodium Current Blocker Ranolazine

(2011) Norishige Morita et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CaMKII in the Cardiovascular System: Sensing Redox States

(2011) Jeffrey R. Erickson et al.   PHYSIOLOGICAL REVIEWS

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

(2010) Man Liu et al.   CIRCULATION RESEARCH

Fibrosis and Cardiac Arrhythmias

(2010) Sanne de Jong et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Facilitation of murine cardiac L-type Cav1.2 channel is modulated by Calmodulin kinase II-dependent phosphorylation of S1512 and S1570

(2010) A. Blaich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Cardiac Action Potential Shortening Driven by Oxidative Stress-Induced Mitochondrial Oscillations in Guinea Pig Cardiomyocytes

(2009) Lufang Zhou et al.   BIOPHYSICAL JOURNAL

Influences of Autonomic Nervous System on Atrial Arrhythmogenic Substrates and the Incidence of Atrial Fibrillation in Diabetic Heart

(2009) Hideki Otake et al.   International Heart Journal

From mitochondrial dynamics to arrhythmias

(2009) M.A. Aon et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy

(2008) Jorge Suarez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Oxidative Stress, Lens Gap Junctions, and Cataracts

(2008) Viviana M. Berthoud et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress

(2008) Ning Li et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart

(2008) D. A. Brown et al.   CARDIOVASCULAR RESEARCH

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Prevalence of Atrial Fibrillation in Community-Dwelling Japanese Aged 40 Years or Older in Japan

(2008) Yasuyuki Iguchi et al.   CIRCULATION JOURNAL

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH

Epidemiology, Risk Factors for Stroke, and Management of Atrial Fibrillation in China

(2008) Dayi Hu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NF-κB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II

(2007) Lijuan L. Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY