Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons – Effects of Nerve Injury

Use and Misuse of Opioids in Chronic Pain

(2018) Nora Volkow et al.   Annual Review of Medicine

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

(2018) Mohammad Zafar Imam et al.   NEUROPHARMACOLOGY

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

(2018) Viola Spahn et al.   Scientific Reports

A nontoxic pain killer designed by modeling of pathological receptor conformations

(2017) V. Spahn et al.   SCIENCE

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons

(2016) Jami L. Saloman et al.   JOURNAL OF NEUROSCIENCE

Opioids and TRPV1 in the peripheral control of neuropathic pain – Defining a target site in the injured nerve

(2016) Dominika Labuz et al.   NEUROPHARMACOLOGY

G Protein-Gated Inwardly Rectifying Potassium Channel Subunits 1 and 2 are Down-Regulated in Rat Dorsal Root Ganglion Neurons and Spinal Cord after Peripheral Axotomy

(2015) Chuang Lyu et al.   Molecular Pain

Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons

(2014) Qi Cai et al.   BRAIN RESEARCH

Opiate-Induced Analgesia: Contributions From Mu, Delta and Kappa Opioid Receptors Mouse Mutants

(2014) Claire Gaveriaux-Ruff   CURRENT PHARMACEUTICAL DESIGN

Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons

(2014) Louise Gorham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

Regulating excitability of peripheral afferents: emerging ion channel targets

(2014) Stephen G Waxman et al.   NATURE NEUROSCIENCE

Normal and abnormal coding of somatosensory stimuli causing pain

(2014) Steven A Prescott et al.   NATURE NEUROSCIENCE

Peripheral opioid receptor blockade increases postoperative morphine demands—A randomized, double-blind, placebo-controlled trial

(2014) Christina Jagla et al.   PAIN

Kir3 channel signaling complexes: focus on opioid receptor signaling

(2014) Karim Nagi et al.   Frontiers in Cellular Neuroscience

The K+channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

(2013) Dinah Nockemann et al.   EMBO Molecular Medicine

Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle

(2013) M-K. Chung et al.   EUROPEAN JOURNAL OF PAIN

Comprehensive RNA-Seq Expression Analysis of Sensory Ganglia with a Focus on Ion Channels and GPCRs in Trigeminal Ganglia

(2013) Stavros Manteniotis et al.   PLoS One

μ-Opioid Receptor Antibody Reveals Tissue-Dependent Specific Staining and Increased Neuronal μ-Receptor Immunoreactivity at the Injured Nerve Trunk in Mice

(2013) Yvonne Schmidt et al.   PLoS One

Impaired Nociception and Peripheral Opioid Antinociception in Mice Lacking Both Kinin B1 and B2 Receptors

(2012) Cecile Cayla et al.   ANESTHESIOLOGY

The inhibition of the nitric oxide–cGMP–PKG–JNK signaling pathway avoids the development of tolerance to the local antiallodynic effects produced by morphine during neuropathic pain

(2012) Arnau Hervera et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cutaneous Nociceptors Lack Sensitisation, but Reveal μ-Opioid Receptor-Mediated Reduction in Excitability to Mechanical Stimulation in Neuropathy

(2012) Yvonne Schmidt et al.   Molecular Pain

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

(2011) C. Stein et al.   PHARMACOLOGICAL REVIEWS

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Immune cell–derived opioids protect against neuropathic pain in mice

(2009) Dominika Labuz et al.   JOURNAL OF CLINICAL INVESTIGATION

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain

(2009) Ilona Obara et al.   PAIN

 -Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System

(2008) Y. Li et al.   JOURNAL OF NEUROSCIENCE