Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

β2-Agonist Therapy in Lung Disease

(2013) Mario Cazzola et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitogen-Activated Protein Kinase Phosphatase 1 as an Inflammatory Factor and Drug Target

(2013) Riku Korhonen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1

(2013) Riku Korhonen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-Acting β2-Agonists Increase Fluticasone Propionate-Induced Mitogen-Activated Protein Kinase Phosphatase 1 (MKP-1) in Airway Smooth Muscle Cells

(2013) Melanie Manetsch et al.   PLoS One

Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma

(2013) Li Liang et al.   RESPIROLOGY

Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?

(2013) Annette J Theron et al.   Drug Design Development and Therapy

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein byStreptococcus pneumoniaeby Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway

(2012) Jiyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism

(2012) Hulya Uzkeser et al.   MEDIATORS OF INFLAMMATION

The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1

(2012) Riku Korhonen et al.   MOLECULAR IMMUNOLOGY

MAPK Phosphatase-1 (MKP-1) Expression Is Up-Regulated by hCG/cAMP and Modulates Steroidogenesis in MA-10 Leydig Cells

(2011) Laura Brion et al.   ENDOCRINOLOGY

Roflumilast with long-acting  2-agonists for COPD: influence of exacerbation history

(2011) E. D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system

(2011) Gergely Vida et al.   FASEB JOURNAL

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease

(2011) Lyn M. Wancket et al.   LIFE SCIENCES

Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase

(2011) Riku Korhonen et al.   MOLECULAR IMMUNOLOGY

Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs

(2010) Riina Nieminen et al.   ARTHRITIS AND RHEUMATISM

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitogen-Activated Protein Kinase Phosphatase-1 Negatively Regulates the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in A549 Human Lung Epithelial Cells

(2010) T. Turpeinen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids

(2010) Lauren E. Shipp et al.   PLoS One

Regulation of the immune response by stress-activated protein kinases

(2009) Mercedes Rincón et al.   IMMUNOLOGICAL REVIEWS

Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice

(2009) W. J. Frazier et al.   JOURNAL OF IMMUNOLOGY

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

(2009) Barry L. Burnette et al.   PHARMACOLOGY

Effect of β2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A

(2008) Manminder Kaur et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling

(2008) Brent E. Bobick et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis

(2008) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke

(2008) Esmaeil Mortaz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

(2008) T. Boutros et al.   PHARMACOLOGICAL REVIEWS