Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

(2018) David Martín-Hernández et al.   Journal of Neuroinflammation

An update on the physiological and therapeutic relevance of GPCR oligomers

(2017) Batoul Farran   PHARMACOLOGICAL RESEARCH

Cannabis and Psychosis: a Critical Overview of the Relationship

(2016) Charles Ksir et al.   Current Psychiatry Reports

Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling

(2015) Lei Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

(2015) Rita Haapakoski et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and clinical response to treatment in depression: A meta-analysis

(2015) R. Strawbridge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The rs1049353 Polymorphism in the CNR1 Gene Interacts With Childhood Abuse to Predict Posttraumatic Threat Symptoms

(2015) Natalie Mota et al.   JOURNAL OF CLINICAL PSYCHIATRY

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The endocannabinoid system in guarding against fear, anxiety and stress

(2015) Beat Lutz et al.   NATURE REVIEWS NEUROSCIENCE

Endocannabinoid signalling in reward and addiction

(2015) Loren H. Parsons et al.   NATURE REVIEWS NEUROSCIENCE

Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis

(2015) Antonietta Gentile et al.   NEUROBIOLOGY OF DISEASE

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?

(2015) Emily Boorman et al.   PSYCHOPHARMACOLOGY

Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis

(2015) Antonietta Gentile et al.   Frontiers in Cellular Neuroscience

The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects

(2014) Amaia M. Erdozain et al.   ADDICTION BIOLOGY

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

(2014) Nikita N. Burke et al.   BRAIN BEHAVIOR AND IMMUNITY

Placebo Effects in a Multiple Sclerosis Spasticity Enriched Clinical Trial with the Oromucosal Cannabinoid Spray (THC/CBD): Dimension and Possible Causes

(2014) Vincenzo Di Marzo et al.   CNS Neuroscience & Therapeutics

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures

(2014) Kora-Mareen Bühler et al.   MOLECULAR GENETICS AND GENOMICS

Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors

(2014) Robert H Pietrzak et al.   NEUROPSYCHOPHARMACOLOGY

Adverse Health Effects of Marijuana Use

(2014) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future

(2014) George Panagis et al.   Frontiers in Psychiatry

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Modulating the endocannabinoid system in human health and disease - successes and failures

(2013) Pál Pacher et al.   FEBS Journal

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study

(2013) A Neumeister et al.   MOLECULAR PSYCHIATRY

Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment

(2013) Marina Mitjans et al.   PSYCHOPHARMACOLOGY

Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression

(2012) Arpana Agrawal et al.   ARCHIVES OF GENERAL PSYCHIATRY

TNF-α-mediated anxiety in a mouse model of multiple sclerosis

(2012) Nabila Haji et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1  Causes Anxiety by Interacting with the Endocannabinoid System

(2012) S. Rossi et al.   JOURNAL OF NEUROSCIENCE

Circulating Endocannabinoid Concentrations and Sexual Arousal in Women

(2012) Carolin Klein et al.   Journal of Sexual Medicine

Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography

(2012) J Hirvonen et al.   MOLECULAR PSYCHIATRY

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

(2012) Annamaria Cattaneo et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid system and mood disorders: Priming a target for new therapies

(2012) Vincenzo Micale et al.   PHARMACOLOGY & THERAPEUTICS

Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence

(2011) Miguel Marcos et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis

(2011) Silvia Rossi et al.   BRAIN BEHAVIOR AND IMMUNITY

Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors

(2011) Fabrizio Benedetti et al.   NATURE MEDICINE

Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

(2011) Nimish Sidhpura et al.   NEUROPHARMACOLOGY

Association Between Depression and Inflammation-Differences by Race and Sex

(2011) Alanna AMYRE Morris et al.   PSYCHOSOMATIC MEDICINE

Outcome of psychiatric symptoms presenting at onset of multiple sclerosis: a retrospective study

(2010) Salvatore Lo Fermo et al.   Multiple Sclerosis Journal

How Placebos Change the Patient's Brain

(2010) Fabrizio Benedetti et al.   NEUROPSYCHOPHARMACOLOGY

Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression

(2010) Palmiero Monteleone et al.   PHARMACOLOGICAL RESEARCH

The pleasures of play: pharmacological insights into social reward mechanisms

(2010) Viviana Trezza et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A randomized controlled trial of adding the nicotine patch to rimonabant for smoking cessation: efficacy, safety and weight gain

(2009) Nancy A. Rigotti et al.   ADDICTION

Endocannabinoid Signaling and Long-Term Synaptic Plasticity

(2009) Boris D. Heifets et al.   Annual Review of Physiology

Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission

(2009) Eva Mikics et al.   BEHAVIOURAL PHARMACOLOGY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Cannabis and anxiety: a critical review of the evidence

(2009) José Alexandre Crippa et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis

(2009) D. Centonze et al.   JOURNAL OF NEUROSCIENCE

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

(2009) G J Norman et al.   MOLECULAR PSYCHIATRY

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

CNR1 Gene is Associated with High Neuroticism and Low Agreeableness and Interacts with Recent Negative Life Events to Predict Current Depressive Symptoms

(2009) Gabriella Juhasz et al.   NEUROPSYCHOPHARMACOLOGY

Voluntary Exercise and Sucrose Consumption Enhance Cannabinoid CB1 Receptor Sensitivity in the Striatum

(2009) Valentina De Chiara et al.   NEUROPSYCHOPHARMACOLOGY

The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation

(2009) Vincenzo Di Marzo   PHARMACOLOGICAL RESEARCH

Endocannabinoids and immune regulation☆

(2009) Rupal Pandey et al.   PHARMACOLOGICAL RESEARCH

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids

(2009) Matthew N. Hill et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress

(2009) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

(2009) Matthew N. Hill et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Physical activity, disability, and mood in the early stage of multiple sclerosis

(2009) Yoojin Suh et al.   Disability and Health Journal

Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment

(2009) Ida S. Haussleiter et al.   Therapeutic Advances in Neurological Disorders

Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder

(2008) Ake T. Lu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Cannabinoid Receptor 1 Gene Association With Nicotine Dependence

(2008) Xiangning Chen et al.   ARCHIVES OF GENERAL PSYCHIATRY

Stress-induced analgesia in mice: evidence for interaction between endocannabinoids and cholecystokinin

(2008) Kaido Kurrikoff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

(2008) Katharina Domschke et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Interleukin-1 (IL-1): A central regulator of stress responses

(2008) Inbal Goshen et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior

(2008) Kyoung-Shim Kim et al.   JOURNAL OF NEUROCHEMISTRY

Chronic Psychoemotional Stress Impairs Cannabinoid-Receptor-Mediated Control of GABA Transmission in the Striatum

(2008) S. Rossi et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid signaling in microglial cells

(2008) Nephi Stella   NEUROPHARMACOLOGY

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

(2008) M. Hill et al.   PHARMACOPSYCHIATRY

Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects

(2008) Emmanuel S. Onaivi et al.   PLoS One

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental enrichment decreases the rewarding but not the activating effects of heroin

(2008) Rana El Rawas et al.   PSYCHOPHARMACOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice

(2007) David J. Rademacher et al.   NEUROPHARMACOLOGY