Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth

(2018) Vincent Giguère   FEBS Journal

Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy

(2018) Marine Gueugneau et al.   Journal of Cachexia Sarcopenia and Muscle

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

(2017) Manuel Blandino-Rosano et al.   Nature Communications

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Differential glucose metabolism in mice and humans affected by McArdle disease

(2016) Thomas O. Krag et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis

(2016) Laetitia Mazelin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential Muscle Involvement in Mice and Humans Affected by McArdle Disease

(2016) Thomas O. Krag et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease

(2016) Josep M. Argilés et al.   Journal of the American Medical Directors Association

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

(2016) Annabel Y. Minard et al.   Cell Reports

Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

(2016) Bolormaa Vandanmagsar et al.   Cell Reports

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

(2016) Maitea Guridi et al.   Skeletal Muscle

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

(2015) Lydia-Ann L.S. Harris et al.   DIABETES

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

(2015) Shihyin Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy

(2015) Alyson A. Fiorillo et al.   Cell Reports

Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015

(2015) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

(2013) Kook Hwan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

(2013) C Bentzinger et al.   Skeletal Muscle

Stressed Liver and Muscle Call on Adipocytes with FGF21

(2013) Yongde Luo et al.   Frontiers in Endocrinology

Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease

(2012) Gisela Nogales-Gadea et al.   BRAIN

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis

(2012) Yejing Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

(2012) S. M. Blattler et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8

(2012) Sung Jin Kim et al.   MOLECULAR CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)

(2011) Yejing Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

(2011) K. Romanino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine

(2010) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dynamics of muscle fibre growth during postnatal mouse development

(2010) Robert B White et al.   BMC DEVELOPMENTAL BIOLOGY

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

(2009) Yejing Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A kinase dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice

(2009) Boris Shor et al.   BMC IMMUNOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

(2009) M. Breuleux et al.   MOLECULAR CANCER THERAPEUTICS

Abnormal growth in mitochondrial disease

(2008) S Wolny et al.   ACTA PAEDIATRICA

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

(2008) Kei Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

GLUT4 Vesicle Recruitment and Fusion Are Differentially Regulated by Rac, AS160, and Rab8A in Muscle Cells

(2008) Varinder K. Randhawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

(2008) Wei-Hua Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Glucose Transporter 4 Translocation by the Rab Guanosine Triphosphatase-Activating Protein AS160/TBC1D4: Role of Phosphorylation and Membrane Association

(2008) Jacqueline Stöckli et al.   MOLECULAR ENDOCRINOLOGY