Editorial Material
Multidisciplinary Sciences
Neil Savage
Summary: Insect intelligence can contribute to the development of microbots.
Editorial Material
Chemistry, Multidisciplinary
Gabrielle A. Leith, Natalia B. Shustova
Summary: In this study, one-dimensional hollow covalent organic frameworks have been prepared and further assembled into toroid-shaped materials.
Editorial Material
Multidisciplinary Sciences
Melissa Suran
Summary: In recent years, STEM programs have been focusing on attracting and retaining Black graduate and undergraduate students, with a new push to replicate the success of certain university programs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Biology
Vy Nguyen, Iain Searle
Summary: A widely accepted model that explains how plants initiate flowering during cold weather may require reevaluation.
Editorial Material
Biochemistry & Molecular Biology
Michael Gross
Summary: As anthropogenic climate change continues to heat up the oceans and atmosphere, the resources people have to cope with or adapt to higher temperatures play a key role in determining the impact of climate change on human lives. Some adaptation strategies, such as increased use of fossil fuel-powered air conditioning, may create feedback loops that worsen the problem.
Editorial Material
Cell Biology
Leonid A. Mirny, Irina Solovei
Summary: The paper discusses three types of chromatin loops and their distinct features and functions, highlighting the role of chromatin looping in genome organization and gene expression. The diversity in structure, maintenance, and function among different types of chromatin loops is emphasized.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Judy A. Staffa
Summary: The treatment of many medical conditions often involves multiple drugs, requiring consideration of pharmacology when examining patient safety outcomes. By analyzing various data streams, risks and underlying mechanisms of action can be identified to provide valuable information for safe use of multiple pharmacotherapies by clinicians and patients.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Editorial Material
Multidisciplinary Sciences
[Anonymous]
Summary: This article consists of editorial selections from the current scientific literature.
Review
Biochemistry & Molecular Biology
Sergei Kirischuk
Summary: Unrelated genetic mutations can lead to convergent manifestations of neurological disorders with similar behavioral phenotypes. Experimental data suggest that the key cause of symptoms may arise from impairment in the communication between neurons, particularly during early development. Changes in excitatory and inhibitory synaptic transmission imbalance might underlie the development of several neurological disorders in adults.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
Eli P. Darnell, Caron A. Jacobson
Summary: In this study, researchers analyzed the outcomes of 356 patients with large B-cell lymphoma treated with CAR-T cell therapy in Germany. They found that while the treatment was effective with a good overall response rate, there was a higher nonrelapse mortality rate, mainly due to infections.
Editorial Material
Energy & Fuels
Christine Milchram
Summary: Current algorithms for battery storage are limited by narrow techno-economic objectives and simplified assumptions of user needs. New research takes citizen preferences into account and develops six battery algorithms that not only support local economic benefits and decarbonization, but also provide explainability.
Editorial Material
Multidisciplinary Sciences
Chris Woolston, Sofia Polo
Summary: Engineer Sofia Polo ensures the cleanliness of the city's water supply by managing storm runoff and tracking pollutants from roofs, car parks, and fertilizers.
Review
Chemistry, Multidisciplinary
Peng Gao, Liangshu Zhong, Buxing Han, Mingyuan He, Yuhan Sun
Summary: The concept of green carbon science aims to achieve carbon neutrality, which has gained global recognition and attention. The transition from fundamental research to practical applications in addressing the urgent need for carbon neutralization must be accelerated. This Review summarizes recent technological developments in the field of green carbon science, focusing on pilot tests, industrial demonstrations, and commercial applications beyond the laboratory stage.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Plant Sciences
Ruju Vashi, Bhoomika M. Patel, Ramesh K. Goyal
Summary: Ashwagandha, a traditional Ayurvedic medicine, has a long history of use in treating inflammation, weakness, pulmonary tuberculosis, and has recently shown potential as an anti-cancer agent. Studies have demonstrated its anti-apoptotic, anti-metastatic, and anti-inflammatory properties in the treatment of breast cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Victor Ambros
Summary: The pioneer transcription factor BLMP-1 regulates the cyclic transcriptional output of hundreds of genes during Caenorhabditis elegans larval development, and is essential for restarting proper gene expression dynamics after nutritionally induced developmental arrest.
Article
Physiology
Suhan Zhou, Jie Guo, Xinxin Liao, Qin Zhou, Xingyu Qiu, Shan Jiang, Nan Xu, Xiaohua Wang, Liang Zhao, Weipeng Hu, Lanyu Xie, Peng Xie, Yu Cui, Yi Yang, Andreas Patzak, Pontus B. Persson, Jianhua Mao, En Yin Lai
Summary: ADAMTS13 shows promise as a new treatment option for acute kidney injury, as it reduces oxidative stress and inflammation in renal ischemia/reperfusion injury.
Editorial Material
Physiology
Pontus B. Persson, Anja B. Persson
Article
Biochemistry & Molecular Biology
Fang Dong, Shan Jiang, Chun Tang, Xiaohua Wang, Xiaoqiu Ren, Qichun Wei, Jiong Tian, Weipeng Hu, Jie Guo, Xiaodong Fu, Linlin Liu, Andreas Patzak, Pontus B. Persson, Fei Gao, En Yin Lai, Liang Zhao
Summary: TMAO aggravates hyperoxaluria-induced kidney injury by triggering the PERK/ROS pathway, which enhances autophagy, apoptosis, and inflammation, and facilitates CaOx crystal deposition in renal tubular cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Editorial Material
Physiology
Pontus B. Persson, Anja B. Persson
Editorial Material
Physiology
Pontus B. Persson
Editorial Material
Physiology
Pontus B. Persson
Editorial Material
Physiology
Pontus B. Persson, Philipp Hillmeister, Anja B. Persson
Article
Urology & Nephrology
Robert Labes, Lennart Brinkmann, Vera A. Kulow, Kameliya Roegner, Susanne Mathia, Bjorn Balcerek, Pontus B. Persson, Christian Rosenberger, Michael Fahling
Summary: This study demonstrates that the hypoxia inducible factor activator daprodustat can prevent the protein phosphorylation changes caused by Cyclosporine-A, and has a protective effect on microcirculation, hemoglobin concentration, and kidney capillary density.
KIDNEY INTERNATIONAL
(2022)
Review
Physiology
Qing Ye, Bing Lan, Huihui Liu, Pontus B. Persson, En Yin Lai, Jianhua Mao
Summary: This article discusses the mechanism of selective glomerular filtration, with a focus on the role of podocytes and the regulation of actin cytoskeleton in maintaining the integrity of the filtration barrier. The study found the presence of autoimmune podocytopathies in children with idiopathic nephrotic syndrome, revealing a new subgroup of the disease.
Editorial Material
Physiology
Pontus B. Persson
Article
Biochemistry & Molecular Biology
Minze Xu, Falk-Bach Lichtenberger, Cem Erdogan, Enyin Lai, Pontus B. Persson, Andreas Patzak, Pratik H. Khedkar
Summary: Reduced renal medullary oxygen supply is a key factor in the pathogenesis of acute kidney injury. Dilating the microvessels of the descending vasa recta may help in renoprotection by restoring renal medullary blood flow. PDE5 inhibitors may protect the pre-constricted microvessels, while sGC activators may be more effective in restoring renal medullary blood flow.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Pontus B. Persson
Article
Peripheral Vascular Disease
Xiaohua Wang, Shan Jiang, Lingyan Fei, Fang Dong, Lanyu Xie, Xingyu Qiu, Yan Lei, Jie Guo, Ming Zhong, Xiaoqiu Ren, Yi Yang, Liang Zhao, Gensheng Zhang, Honghong Wang, Chun Tang, Luyang Yu, Ruisheng Liu, Andreas Patzak, Pontus B. Persson, Michael Hultstrom, Qichun Wei, En Yin Lai, Zhihua Zheng
Summary: This study found that the RhoA/ROCK pathway may play an important role in tacrolimus-induced hypertension by enhancing the vasoconstrictive effect of Ang II. Reactive oxygen species may participate in this process by activating the RhoA/ROCK pathway.
Editorial Material
Physiology
Pontus B. Persson, Anja Bondke Persson
Editorial Material
Physiology
Pontus B. Persson, Philipp Hillmeister, Anja B. Persson
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.
