Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses

(2018) Nicholas Rinkenberger et al.   mBio

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

(2017) Qingfeng Chen et al.   NATURE

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

(2017) Cheng-Chang Chen et al.   Nature Protocols

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

(2017) Sensen Zhang et al.   Protein & Cell

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

UniProt: the universal protein knowledgebase

(2016)   NUCLEIC ACIDS RESEARCH

Silicon-containing halogenated poly(amides) derived from diacids with aminoacidic and imidic moieties in the side chain: synthesis, characterization, optical studies and thermal properties

(2016) L. H. Tagle et al.   POLYMER BULLETIN

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

(2015) Yuxuan Miao et al.   CELL

Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV

(2015) Soonhong Park et al.   EMBO REPORTS

PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene

(2015) Jessica A. Valadez et al.   GENE

Novel Role of TRPML2 in the Regulation of the Innate Immune Response

(2015) Lu Sun et al.   JOURNAL OF IMMUNOLOGY

The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function

(2015) Math P. Cuajungco et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Catalytic Reductive Dehydration of Tertiary Amides to Enamines under Hydrosilylation Conditions

(2014) Alexey Volkov et al.   ORGANIC LETTERS

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

(2014) Cheng-Chang Chen et al.   Nature Communications

Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking

(2014) Rachael Zoe Murray et al.   Frontiers in Immunology

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Functional 3-Arylisoxazoles and 3-Aryl-2-isoxazolines from Reaction of Aryl Nitrile Oxides and Enolates: Synthesis and Reactivity

(2013) Paola Vitale et al.   SYNTHESIS-STUTTGART

Feast or famine

(2012) Kartik Venkatachalam et al.   Autophagy

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Constitutive Activity of TRPML2 and TRPML3 ChannelsversusActivation by Low Extracellular Sodium and Small Molecules

(2012) Christian Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One-Pot Synthesis of Indolo[2,3-c]quinolin-6-ones by Sequential Photocyclizations of 3-(2-Azidophenyl)-N-phenylacrylamides

(2012) Wei Zhang et al.   SYNLETT

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Cytokine release from innate immune cells: association with diverse membrane trafficking pathways

(2011) P. Lacy et al.   BLOOD

RefGenes: identification of reliable and condition specific reference genes for RT-qPCR data normalization

(2011) Tomas Hruz et al.   BMC GENOMICS

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mucolipin-3 Regulates Luminal Calcium, Acidification, and Membrane Fusion in the Endosomal Pathway

(2011) Benjamin Lelouvier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Cesium Carbonate Promoted N-Alkylations of Aromatic Cyclic Imides Under Microwave Irradiation

(2011) María Blanco et al.   SYNTHESIS-STUTTGART

Opening the TRPML Gates

(2010) Soichiro Yamaguchi et al.   CHEMISTRY & BIOLOGY

Small Molecule Activators of TRPML3

(2010) Christian Grimm et al.   CHEMISTRY & BIOLOGY

Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice

(2010) Simone Jörs et al.   PLoS One

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines

(2009) Tanaji N. Bansode et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in CCR2 antagonists

(2009) Mingde Xia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Identification of the Penta-EF-hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1

(2009) Silvia Vergarajauregui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Ca2+Channel TRPML3 Regulates Membrane Trafficking and Autophagy

(2009) Hyun Jin Kim et al.   TRAFFIC