Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

Cooperativity and flexibility in enzyme evolution

(2018) Anna Pabis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System

(2018) Daiana A. Capdevila et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallochaperones and metalloregulation in bacteria

(2017) Daiana A. Capdevila et al.   Essays in Biochemistry

Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator

(2017) Rongfeng Zhu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR

(2017) Guijie Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation

(2017) Rongfeng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropy redistribution controls allostery in a metalloregulatory protein

(2017) Daiana A. Capdevila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropy in molecular recognition by proteins

(2017) José A. Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic study of the cysteine oxidation-mediated induction of the Escherichia coli MarR regulator

(2017) Rongfeng Zhu et al.   TETRAHEDRON

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus

(2017) Hui Peng et al.   ACS Infectious Diseases

Regulation of Metabolic Pathways by MarR Family Transcription Factors

(2017) Anne Grove   Computational and Structural Biotechnology Journal

Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis

(2017) Yun-Rong Gao et al.   Scientific Reports

Characterization of SlyA in Shigella flexneri Identifies a Novel Role in Virulence

(2016) Natasha Weatherspoon-Griffin et al.   INFECTION AND IMMUNITY

How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator

(2016) Youngchang Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the semi-conserved histidine residue in the light-sensing domain of LitR, a MerR-type photosensory transcriptional regulator

(2016) Hideaki Takano et al.   MICROBIOLOGY-SGM

Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices

(2016) D. K. Deochand et al.   Molecular BioSystems

The role of protein dynamics in the evolution of new enzyme function

(2016) Eleanor Campbell et al.   Nature Chemical Biology

Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression

(2016) Madhanagopal Anandapadamanaban et al.   STRUCTURE

Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species Conservation

(2016) Declan Clarke et al.   STRUCTURE

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

(2016) Alessia Liguori et al.   PLoS Pathogens

The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism

(2015) Hiroshi Otani et al.   NUCLEIC ACIDS RESEARCH

On the relationship between NMR-derived amide order parameters and protein backbone entropy changes

(2015) Kim A. Sharp et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ligand-Binding Pocket Bridges DNA-Binding and Dimerization Domains of the Urate-Responsive MarR Homologue MftR from Burkholderia thailandensis

(2014) Ashish Gupta et al.   BIOCHEMISTRY

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Crystal Structure of the Transcriptional Regulator Rv0678 ofMycobacterium tuberculosis

(2014) Abhijith Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence

(2014) Misu Sanson et al.   NUCLEIC ACIDS RESEARCH

MarR family transcription factors

(2013) Anne Grove   CURRENT BIOLOGY

Mutational Analysis of the Multiple-Antibiotic Resistance Regulator MarR Reveals a Ligand Binding Pocket at the Interface between the Dimerization and DNA Binding Domains

(2013) V. Duval et al.   JOURNAL OF BACTERIOLOGY

Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family

(2013) Gregory C. Campanello et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Observation of the Ion-Pair Dynamics at a Protein–DNA Interface by NMR Spectroscopy

(2013) Kurtis M. Anderson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric inhibition through suppression of transient conformational states

(2013) Shiou-Ru Tzeng et al.   Nature Chemical Biology

The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli

(2013) Ziyang Hao et al.   Nature Chemical Biology

Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR

(2013) Ivan Birukou et al.   NUCLEIC ACIDS RESEARCH

Backbone and sterospecific methyl side chain resonance assignments of the homodimeric zinc sensor AdcR (32 kDa) in the apo- and Zn(II)-bound states

(2012) Alfredo J. Guerra et al.   Biomolecular NMR Assignments

Structural Basis for Intrinsic Thermosensing by the Master Virulence Regulator RovA ofYersinia

(2012) Nick Quade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of 15N relaxation rates in perdeuterated proteins by TROSY-based methods

(2012) Nils-Alexander Lakomek et al.   JOURNAL OF BIOMOLECULAR NMR

Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling

(2012) Sven G. Hyberts et al.   JOURNAL OF BIOMOLECULAR NMR

Energetics of Zinc-Mediated Interactions in the Allosteric Pathways of Metal Sensor Proteins

(2012) Dhruva K. Chakravorty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Ni(II) coordination to mixed sites modulates DNA binding of HpNikR via a long-range effect

(2012) A. L. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance

(2012) F. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactococcus lactis ZitR Is a Zinc-Responsive Repressor Active in the Presence of Low, Nontoxic Zinc Concentrations In Vivo

(2011) D. Llull et al.   JOURNAL OF BACTERIOLOGY

Crystal Structures of SlyA Protein, a Master Virulence Regulator ofSalmonella, in Free and DNA-bound States

(2011) Kyle T. Dolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State

(2011) Alfredo J. Guerra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Metalloregulatory Zinc Site in Streptococcus pneumoniae AdcR, a Zinc-activated MarR Family Repressor

(2010) Hermes Reyes-Caballero et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of conformational entropy in molecular recognition by calmodulin

(2010) Michael S Marlow et al.   Nature Chemical Biology

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis

(2010) Y.-M. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance

(2010) Cecilia Andrésen et al.   PROTEIN SCIENCE

Molecular Mechanisms of Ligand-Mediated Attenuation of DNA Binding by MarR Family Transcriptional Regulators

(2010) I. C. Perera et al.   Journal of Molecular Cell Biology

On prokaryotic intelligence: Strategies for sensing the environment

(2009) Pedro C. Marijuán et al.   BIOSYSTEMS

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Protective capacities of cell surface-associated proteins of Streptococcus suis mutants deficient in divalent cation-uptake regulators

(2009) J. Aranda et al.   MICROBIOLOGY-SGM

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica Serovar Typhimurium

(2009) Hyunjin Yoon et al.   PLoS Pathogens

SarZ Promotes the Expression of Virulence Factors and Represses Biofilm Formation by Modulating SarA and agr in Staphylococcus aureus

(2008) S. Tamber et al.   INFECTION AND IMMUNITY

Structural Insight on the Mechanism of Regulation of the MarR Family of Proteins: High-Resolution Crystal Structure of a Transcriptional Repressor from Methanobacterium thermoautotrophicum

(2008) Vivian Saridakis et al.   JOURNAL OF MOLECULAR BIOLOGY

The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR

(2008) M. S. Wilke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations

(2002) Darón I. Freedberg et al.   PROTEIN SCIENCE