Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review

What is new in pain modification in osteoarthritis?

(2018) Rachel E Miller et al.   RHEUMATOLOGY

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

(2018) Huiping Ding et al.   Science Translational Medicine

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

(2017) Bruno R da Costa et al.   LANCET

Osteoarthritis: the genesis of pain

(2017) Kai Fu et al.   RHEUMATOLOGY

Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis

(2016) Brian J. Cole et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and Safety of Tanezumab on Osteoarthritis Knee and Hip Pains: A Meta-Analysis of Randomized Controlled Trials

(2016) Junyuan Chen et al.   PAIN MEDICINE

Alternative Methods for Defining Osteoarthritis and the Impact on Estimating Prevalence in a US Population-Based Survey

(2016) Miriam G. Cisternas et al.   ARTHRITIS CARE & RESEARCH

Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis

(2016) Shun-Li Kan et al.   PLoS One

Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

(2015) Marc C Hochberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Drug developers reboot anti-NGF pain programmes

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee

(2015) T.J. Schnitzer et al.   OSTEOARTHRITIS AND CARTILAGE

Opioid Induced Hyperalgesia

(2015) Peter Yi et al.   PAIN MEDICINE

A Mechanism-Based Approach to the Management of Osteoarthritis Pain

(2015) Ezra Cohen et al.   Current Osteoporosis Reports

Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens

(2014) Marlene Fransen et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain

(2014) Thomas J Schnitzer et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review

(2014) E. Lluch et al.   EUROPEAN JOURNAL OF PAIN

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

(2014) H. Bliddal et al.   Obesity Reviews

Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: Results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee

(2014) Paul J. Tiseo et al.   PAIN

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis

(2013) Sandeep Patel et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Viscosupplementation for Osteoarthritis of the Knee

(2013) Anne W.S. Rutjes et al.   ANNALS OF INTERNAL MEDICINE

Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis

(2013) Stephen P. Messier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage

(2013) Carlos Sostres et al.   ARTHRITIS RESEARCH & THERAPY

Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial

(2012) Suzan Abou-Raya et al.   AGE AND AGEING

Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement

(2012) T. Graven-Nielsen et al.   ARTHRITIS AND RHEUMATISM

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

(2012) Laura McKelvey et al.   JOURNAL OF NEUROCHEMISTRY

A Systematic Review of Duloxetine for Osteoarthritic Pain: What is the Number Needed to Treat, Number Needed to Harm, and Likelihood to be Helped or Harmed?

(2012) Leslie Citrome et al.   POSTGRADUATE MEDICINE

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development

(2012) Andrew D Cook et al.   ARTHRITIS RESEARCH & THERAPY

Duloxetine added to oral nonsteroidal anti-inflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo-controlled trial

(2011) E.P. Frakes et al.   CURRENT MEDICAL RESEARCH AND OPINION

A review of the clinical evidence for exercise in osteoarthritis of the hip and knee

(2010) Kim L. Bennell et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT