Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments

(2018) Christine E. Hulseberg et al.   mBio

Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

(2018) Alexander Kühnl et al.   mBio

pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion

(2017) Tanay M. Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZMPSTE24 defends against influenza and other pathogenic viruses

(2017) Bishi Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses

(2017) Xuesen Zhao et al.   JOURNAL OF VIROLOGY

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

(2017) Kevin Tartour et al.   PLoS Pathogens

Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion

(2016) Rolf J. Ryham et al.   BIOPHYSICAL JOURNAL

Fusion of Enveloped Viruses in Endosomes

(2016) Judith M. White et al.   TRAFFIC

Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3

(2016) Shenglong Ling et al.   Scientific Reports

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

(2015) Jingyou Yu et al.   Cell Reports

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Identification of an endocytic signal essential for the antiviral action of IFITM3

(2014) Rui Jia et al.   CELLULAR MICROBIOLOGY

IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection

(2014) Xun Zhu et al.   CELLULAR MICROBIOLOGY

A Novel Mode of Poxvirus Superinfection Exclusion That Prevents Fusion of the Lipid Bilayers of Viral and Cellular Membranes

(2014) J. P. Laliberte et al.   JOURNAL OF VIROLOGY

The Antiviral Restriction Factors IFITM1, 2 and 3 Do Not Inhibit Infection of Human Papillomavirus, Cytomegalovirus and Adenovirus

(2014) Cody J. Warren et al.   PLoS One

A Membrane Topology Model for Human Interferon Inducible Transmembrane Protein 1

(2014) Stuart Weston et al.   PLoS One

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

(2014) Kevin Tartour et al.   Retrovirology

Lassa virus entry requires a trigger-induced receptor switch

(2014) L. T. Jae et al.   SCIENCE

IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion

(2014) Tanay M. Desai et al.   PLoS Pathogens

The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry

(2013) Samad Amini-Bavil-Olyaee et al.   Cell Host & Microbe

Virus entry at a glance

(2013) Y. Yamauchi et al.   JOURNAL OF CELL SCIENCE

IFITMs Restrict the Replication of Multiple Pathogenic Viruses

(2013) Jill M. Perreira et al.   JOURNAL OF MOLECULAR BIOLOGY

IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus

(2013) R. Mudhasani et al.   JOURNAL OF VIROLOGY

The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication

(2013) S. P. John et al.   JOURNAL OF VIROLOGY

Fusion of Mature HIV-1 Particles Leads to Complete Release of a Gag-GFP-Based Content Marker and Raises the Intraviral pH

(2013) Sergi Padilla-Parra et al.   PLoS One

Defining the Range of Pathogens Susceptible to Ifitm3 Restriction Using a Knockout Mouse Model

(2013) Aaron R. Everitt et al.   PLoS One

Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction

(2013) Tsai-Yu Lin et al.   Cell Reports

IFITM Proteins Restrict Viral Membrane Hemifusion

(2013) Kun Li et al.   PLoS Pathogens

Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells

(2012) Naoyuki Kondo et al.   PLoS One

Synchronized Retrovirus Fusion in Cells Expressing Alternative Receptor Isoforms Releases the Viral Core into Distinct Sub-cellular Compartments

(2012) Sergi Padilla-Parra et al.   PLoS Pathogens

Ifitm3 Limits the Severity of Acute Influenza in Mice

(2012) Charles C. Bailey et al.   PLoS Pathogens

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

(2011) Michelle de la Vega et al.   Retrovirology

Imaging Single Retrovirus Entry through Alternative Receptor Isoforms and Intermediates of Virus-Endosome Fusion

(2011) Naveen K. Jha et al.   PLoS Pathogens

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

(2011) Eric M. Feeley et al.   PLoS Pathogens

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

(2011) Erik de Vries et al.   PLoS Pathogens

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

(2010) D. Jiang et al.   JOURNAL OF VIROLOGY

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Characterization of Lassa Virus Cell Entry and Neutralization with Lassa Virus Pseudoparticles

(2009) F.-L. Cosset et al.   JOURNAL OF VIROLOGY

Molecular assemblies and membrane domains in multivesicular endosome dynamics

(2008) Thomas Falguières et al.   EXPERIMENTAL CELL RESEARCH

pH-Induced Activation of Arenavirus Membrane Fusion Is Antagonized by Small-Molecule Inhibitors

(2008) J. York et al.   JOURNAL OF VIROLOGY

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY