Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80

Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop

(2017) Evelyn Prugar et al.   GENETICS

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure

(2017) Vera D. Rinaldi et al.   MOLECULAR CELL

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2

(2017) Alan M V West et al.   NUCLEIC ACIDS RESEARCH

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

(2017) Marina Marcet-Ortega et al.   PLoS Genetics

Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop

(2017) Evelyn Prugar et al.   GENETICS

Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics

(2016) Raymond T. Suhandynata et al.   PLoS One

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression

(2016) Linda Shyue Huey Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

(2016) Vijayalakshmi V. Subramanian et al.   PLOS BIOLOGY

Mek1 Down Regulates Rad51 Activity during Yeast Meiosis by Phosphorylation of Hed1

(2016) Tracy L. Callender et al.   PLoS Genetics

Sequestration of mRNAs Modulates the Timing of Translation during Meiosis in Budding Yeast

(2015) Liang Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Gradual Implementation of the Meiotic Recombination Program via Checkpoint Pathways Controlled by Global DSB Levels

(2015) Neeraj Joshi et al.   MOLECULAR CELL

Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis

(2015) Xiangyu Chen et al.   PLOS BIOLOGY

The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

(2015) Sarai Pacheco et al.   PLoS Genetics

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase

(2014) V. V. Subramanian et al.   Cold Spring Harbor Perspectives in Biology

A Method for Sporulating Budding Yeast Cells That Allows for Unbiased Identification of Kinase Substrates Using Stable Isotope Labeling by Amino Acids in Cell Culture

(2014) Ray Suhandynata et al.   G3-Genes Genomes Genetics

Down-Regulation of Rad51 Activity during Meiosis in Yeast Prevents Competition with Dmc1 for Repair of Double-Strand Breaks

(2014) Yan Liu et al.   PLoS Genetics

Direct and Indirect Control of the Initiation of Meiotic Recombination by DNA Damage Checkpoint Mechanisms in Budding Yeast

(2013) Bilge Argunhan et al.   PLoS One

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR)

(2013) S. Gray et al.   Open Biology

Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor

(2013) David Ontoso et al.   PLoS Genetics

Meiotic Prophase Requires Proteolysis of M Phase Regulators Mediated by the Meiosis-Specific APC/CAma1

(2012) Elwy Okaz et al.   CELL

Phosphorylation meets nuclear import: a review

(2012) Jonathan D Nardozzi et al.   Cell Communication and Signaling

The Sum1/Ndt80 Transcriptional Switch and Commitment to Meiosis in Saccharomyces cerevisiae

(2012) E. Winter   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Rad51 Is an Accessory Factor for Dmc1-Mediated Joint Molecule Formation During Meiosis

(2012) V. Cloud et al.   SCIENCE

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

Cdc7-Dbf4 Is a Gene-Specific Regulator of Meiotic Transcription in Yeast

(2011) H.-C. Lo et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear localization of the meiosis-specific transcription factor Ndt80 is regulated by the pachytene checkpoint

(2011) Ying Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

(2011) Mardo Kõivomägi et al.   NATURE

Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination

(2010) Keun P. Kim et al.   CELL

Mek1 Kinase Governs Outcomes of Meiotic Recombination and the Checkpoint Response

(2010) Hsin-Yen Wu et al.   CURRENT BIOLOGY

A Mec1- and PP4-Dependent Checkpoint Couples Centromere Pairing to Meiotic Recombination

(2010) Jill E. Falk et al.   DEVELOPMENTAL CELL

Mek1 Suppression of Meiotic Double-Strand Break Repair Is Specific to Sister Chromatids, Chromosome Autonomous and Independent of Rec8 Cohesin Complexes

(2010) T. L. Callender et al.   GENETICS

The Cdk1 and Ime2 Protein Kinases Trigger Exit from Meiotic Prophase in Saccharomyces cerevisiae by Inhibiting the Sum1 Transcriptional Repressor

(2010) M. E. Shin et al.   MOLECULAR AND CELLULAR BIOLOGY

Double Holliday junctions are intermediates of DNA break repair

(2010) Malgorzata Bzymek et al.   NATURE

Trying to Avoid Your Sister

(2010) Jessica P. Lao et al.   PLOS BIOLOGY

The Ime2 Protein Kinase Enhances the Disassociation of the Sum1 Repressor from Middle Meiotic Promoters

(2009) N. T. Ahmed et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Meiotic Recombination via Mek1-Mediated Rad54 Phosphorylation

(2009) Hengyao Niu et al.   MOLECULAR CELL

Meiosis I Is Established through Division-Specific Translational Control of a Cyclin

(2008) Thomas M. Carlile et al.   CELL

Phosphorylation of the Axial Element Protein Hop1 by Mec1/Tel1 Ensures Meiotic Interhomolog Recombination

(2008) Jesús A. Carballo et al.   CELL

Global Analysis of the Meiotic Crossover Landscape

(2008) Stacy Y. Chen et al.   DEVELOPMENTAL CELL

Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination

(2008) H. Sasanuma et al.   GENES & DEVELOPMENT

Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis

(2008) A. Sourirajan et al.   GENES & DEVELOPMENT

Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast

(2008) L. Wan et al.   GENES & DEVELOPMENT

Hed1 regulates Rad51-mediated recombination via a novel mechanism

(2008) V. Busygina et al.   GENES & DEVELOPMENT

The C-terminal Region of the Meiosis-specific Protein Kinase Ime2 Mediates Protein Instability and is Required for Normal Spore Formation in Budding Yeast

(2008) Fatih Sari et al.   JOURNAL OF MOLECULAR BIOLOGY