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Developmental Biology
Lesley N. Weaver, Daniela Drummond-Barbosa
Summary: The study reveals the crucial roles of nuclear receptor signaling in controlling reproduction, with Hormone receptor 4 (Hr4) identified as an oogenesis regulator required in the ovary and muscles. Hr4 is essential for germline stem cell maintenance, follicle growth, and early germline cyst survival, highlighting the complexity of nuclear receptor regulation in oogenesis.
Article
Multidisciplinary Sciences
Georgios N. Hatzopoulos, Tim Kuekenshoener, Niccolo Banterle, Tatiana Favez, Isabelle Flueckiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Goenczy
Summary: The study presents the development of monobodies against Chlamydomonas reinhardtii SAS-6 and their effects on ring assembly and stacking, using X-ray crystallography, atomic force microscopy, and cryo-electron microscopy.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Kuo Liu, Siming Zhang, Dongxiang Wu, Langli Luo, Xianhu Sun, Xiaobo Chen, Dmitri Zakharov, Shaobo Cheng, Yimei Zhu, Judith C. Yang, Guofeng Wang, Guangwen Zhou
Summary: By utilizing in situ atomic-resolution electron microscopy observations and atomistic modeling, this study demonstrates the significant impact of surface steps on inducing compositional and structural evolution in the subsurface of a Cu(Au) solid solution. Surface steps induce the formation of ordered phases in the subsurface, showcasing the instant propagation of surface dynamics into the subsurface region.
Article
Genetics & Heredity
Christine Rourke, Aimee Jaramillo-Lambert
Summary: During meiotic prophase I, timely release of sister chromatid cohesin subunit REC-8 is crucial for the accurate segregation of homologous chromosomes. This study reveals that the role of TOP-2 in meiosis differs between spermatogenesis and oogenesis. The findings highlight the important regulatory role of TOP-2 in meiotic chromosome segregation.
Article
Genetics & Heredity
Jennifer D. Cohen, Carla E. Cadena del Castillo, Nicholas D. Serra, Andres Kaech, Anne Spang, Meera Sundaram
Summary: The study focused on the role of PTR-4, a Patched-related protein, in Caenorhabditis elegans, revealing its involvement in the assembly of the precuticle matrix and its localization at the apical side of certain epithelial cells. Defects in PTR-4 lead to abnormalities in cuticle and molting, possibly due to earlier disorganization in the precuticle layer.
Article
Genetics & Heredity
Mohamed T. Elaswad, Brooklynne M. Watkins, Katherine G. Sharp, Chloe Munderloh, Jennifer A. Schisa
Summary: This article explores the regulation and function of RNP granules, a type of cellular structure, using the germ line of Caenorhabditis elegans as a model system. The study identifies distinct phases and properties of RNA-binding proteins within the granules, which may underlie their response to stress. It also highlights the differential role of MEG-3 in oocyte RNP granules compared to embryos, and suggests a potential role for the translational repressor PUF-5 in oogenesis.
G3-GENES GENOMES GENETICS
(2022)
Article
Genetics & Heredity
Anahita Daryabeigi, Alexander Woglar, Antoine Baudrimont, Nicola Silva, Dimitra Paouneskou, Cornelia Vesely, Manuel Rauter, Alexandra Penkner, Michael Jantsch, Verena Jantsch
Editorial Material
Cell Biology
Nicola Silva, Verena Jantsch
JOURNAL OF CELL BIOLOGY
(2016)
Article
Biology
Oliver Crawley, Consuelo Barroso, Sarah Testori, Nuria Ferrandiz, Nicola Silva, Maikel Castellano-Pozo, Angel Luis Jaso-Tamame, Enrique Martinez-Perez
Article
Genetics & Heredity
Anahita Daryabeigi, Alexander Woglar, Antoine Baudrimont, Nicola Silva, Dimitra Paouneskou, Cornelia Vesely, Manuel Rauter, Alexandra Penkner, Michael Jantsch, Verena Jantsch
Article
Genetics & Heredity
Ye Hong, Maria Velkova, Nicola Silva, Marlene Jagut, Viktor Scheidt, Karim Labib, Verena Jantsch, Anton Gartner
Article
Cell Biology
Nicola Silva, Nuria Ferrandiz, Consuelo Barroso, Silvia Tognetti, James Lightfoot, Oana Telecan, Vesela Encheva, Peter Faull, Simon Hanni, Andre Furger, Ambrosius P. Snijders, Christian Speck, Enrique Martinez-Perez
DEVELOPMENTAL CELL
(2014)
Article
Genetics & Heredity
Eva Janisiw, Maria Rosaria Dello Stritto, Verena Jantsch, Nicola Silva
Article
Multidisciplinary Sciences
Marcello Germoglio, Anna Valenti, Ines Gallo, Chiara Forenza, Pamela Santonicola, Nicola Silva, Adele Adamo
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Eva Janisiw, Marilina Raices, Fabiola Balmir, Luis F. Paulin, Antoine Baudrimont, Arndt von Haeseler, Judith L. Yanowitz, Verena Jantsch, Nicola Silva
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Maria Velkova, Nicola Silva, Maria Rosaria Dello Stritto, Alexander Schleiffer, Pierre Barraud, Markus Hartl, Verena Jantsch
Summary: Bloom syndrome, caused by mutations in BTR complex proteins, is characterized by growth deficiency, short stature, skin photosensitivity, and increased cancer predisposition. Cellular characteristics include increased sister chromatid exchange on chromosomes. Research suggests that RMI2 in meiosis may lower the risk of translocations and genome rearrangements.
Article
Genetics & Heredity
Nicola R. Silva, Maikel Castellano-Pozo, Kenichiro J. Matsuzaki, Consuelo Barroso, Monica P. Roman-Trufero, Hannah Craig, Darren P. Brooks, R. Elwyn Isaac, Simon P. Boulton, Enrique Martinez-Perez
Summary: The study uncovers an unexpected role for aminopeptidase P (APP1) in genome stability, indicating functional connections between aminopeptidase-mediated protein catabolism and DNA replication. Despite involvement in preventing replication stress, APP1 does not have an apparent role in DNA double-strand break repair.
Article
Genetics & Heredity
Debabrata Das, Shalini Trivedi, Jitka Blazickova, Swathi Arur, Nicola Silva
Summary: In this study, a phosphorylation site Serine 285 in HTP-3 protein during meiotic prophase I was identified. The phosphorylation at this site is independent of canonical meiotic protein kinases and does not regulate HTP-3-dependent meiotic processes.
G3-GENES GENOMES GENETICS
(2022)
Article
Cell Biology
Tara Hicks, Shalini Trivedi, Mikayla Eppert, Richard Bowman, Hui Tian, Amna Dafalla, Caroline Crahan, Sarit Smolikove, Nicola Silva
Summary: Faithful chromosome segregation into gametes relies on Spo11-induced DNA double-strand breaks (DSBs). In this study, the authors investigate the temporal dynamics of Spo11 activity in Caenorhabditis elegans and find that DSB induction occurs from early meiotic prophase I to mid-late pachynema. Late DSBs are essential for crossover formation and are preferentially processed by EXO-1 and DNA-2.
Article
Biochemistry & Molecular Biology
Shalini Trivedi, Jitka Blazickova, Nicola Silva
Summary: This study reveals the important role of the BRC-1/BRCA1-BRD-1/BARD1 and PARG-1/PARG complex in meiotic cells for accurate DNA repair and genome integrity. Depletion of both BRC-1 and PARG-1 leads to synthetic lethality and reduces crossover formation and break repair. These factors function independently in developing oocytes, operating in different pathways. The study also highlights the influence of BRC-1-PARG-1 in DNA repair pathway choice.
NUCLEIC ACIDS RESEARCH
(2022)