Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations

The effects of mutational processes and selection on driver mutations across cancer types

(2018) Daniel Temko et al.   Nature Communications

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

(2018) N. J. Haradhvala et al.   Nature Communications

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

(2018) Tania V. Silvas et al.   Scientific Reports

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

(2018) David Tamborero et al.   Genome Medicine

The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes

(2017) Rebecca C. Poulos et al.   NUCLEIC ACIDS RESEARCH

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

(2016) James I. Hoopes et al.   Cell Reports

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

(2015) Anne ML Jansen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

(2015) Artem G. Lada et al.   PLoS Genetics

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations

(2014) Yaser R Hussein et al.   MODERN PATHOLOGY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

(2014) Stephen Henderson et al.   Cell Reports

Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice

(2013) L Heinzerling et al.   BRITISH JOURNAL OF CANCER

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

(2013) Colleen M. Holtz et al.   NUCLEIC ACIDS RESEARCH

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas

(2012) Paul K. Paik et al.   CANCER

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Molecular Epidemiology of EGFR and KRAS Mutations in 3,026 Lung Adenocarcinomas: Higher Susceptibility of Women to Smoking-Related KRAS-Mutant Cancers

(2012) S. Dogan et al.   CLINICAL CANCER RESEARCH

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Eukaryotic Lagging Strand DNA Replication Employs a Multi-pathway Mechanism That Protects Genome Integrity

(2010) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

(2009) Koichi Ichimura et al.   NEURO-ONCOLOGY

Sunlight ultraviolet irradiation andBRAFV600 mutagenesis in human melanoma

(2008) Ahmad Besaratinia et al.   HUMAN MUTATION

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE