Article
Agronomy
Ju-Young Jung, Cheol Woo Min, So Wun Kim, Ravi Gupta, Woojong Jang, Kyong-Hwan Bang, Yu-Jin Kim, Ick-Hyun Jo, Sun Tae Kim
Summary: Ginseng, which is often exposed to environmental stresses such as heat, salt, and drought, has been found to have potential salt-responsive proteins through fluid proteomic analysis. These proteins are associated with photosynthesis, protein synthesis, cell binding, and various metabolisms.
Article
Biochemistry & Molecular Biology
Ju-Young Jung, Cheol Woo Min, Jeong Woo Jang, Ravi Gupta, Ji-Hyun Kim, Young-Hun Kim, Sung Won Cho, Young Hun Song, Ick-Hyun Jo, Randeep Rakwal, Yu-Jin Kim, Sun Tae Kim
Summary: This study reveals the proteome changes in ginseng leaves in response to salt stress and identifies the salt-responsive protein, PgGH17, which improves salt tolerance when heterologously expressed in Arabidopsis thaliana.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Qinggang Yin, Xiaoyan Han, Jingwang Chen, Zongxian Han, Liang Shen, Wei Sun, Shilin Chen
Summary: The study identified panasenoside and kaempferol 3-O-glucoside as commonly accumulated flavonol glycosides in ginseng leaves with cultivation years. A total of 50 UDP-glycosyltransferases (UGTs) were screened out to explore flavonol glycosylation in ginseng, with specific UGTs identified for the formation and modification of kaempferol 3-O-glucoside. The study highlights the significance of integrated metabolite profiles, proteomics, and phylogenetic analysis in understanding flavonol glycosylation pathways in ginseng.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Plant Sciences
Paul H. Goodwin, Madison A. Best
Summary: Ginsenosides have been widely studied for their medicinal benefits and their role in ginseng plant biology. They play a crucial role in ginseng's defense against biotic stresses, providing antimicrobial, antifeedant, and allelopathic activities. Ginsenosides also have roles in ginseng development and abiotic stress tolerance.
Review
Biochemistry & Molecular Biology
Xianmei Yin, Haoyu Hu, Xiaofeng Shen, Xiangyan Li, Jin Pei, Jiang Xu
Summary: Ginseng, known as the king of herbs, has been used as an important traditional medicine for thousands of years. Ginsenosides, bioactive compounds of ginseng, have posed challenges for research and development due to their complexity. In recent years, the emergence of new biological research tools, particularly omics and bioinformatic tools, has become a major trend in ginseng research.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Junyun Cheng, Jie Chen, Jie Liao, Tianhao Wang, Xin Shao, Jinbo Long, Penghui Yang, Anyao Li, Zheng Wang, Xiaoyan Lu, Xiaohui Fan
Summary: A new approach called TCM-seq was developed to comprehensively evaluate the therapeutic effects of Panax ginseng and Panax notoginseng at the transcriptomic level. The study revealed significant differences in the regulatory effects of ginseng and notoginseng on genes, functional pathways, and molecular networks. This research provides a new paradigm for exploring the mechanisms of action of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Food Science & Technology
Prasad Kesanakurti, Subramanyam Ragupathy, Adam C. Faller, Dhivya Shanmughanandhan, Francesco Buongiorno, Isabella Della Noce, Zhengfei Lu, Yanjun Zhang, Steven G. Newmaster
Summary: Authentication of Panax ginseng and Panax quinquefolius herbal dietary supplements is crucial in mitigating adulteration and substitution issues in the international ginseng supply chain. Species-specific hydrolysis probe qPCR assays have been developed and validated, demonstrating high specificity and reliability for the identification of target species in raw materials.
Article
Plant Sciences
Xiaoying Li, Xianhui Cheng, Baosheng Liao, Jiang Xu, Xu Han, Jinbo Zhang, Zhiwei Lin, Lianghai Hu
Summary: In this study, a large number of proteins were identified from ginseng root and cauline leaf, revealing their different roles in photosynthesis and metabolic processes. The expression differences of functional proteins related to ginsenoside synthesis in different parts were also found, providing insights into the synthesis of ginsenosides and guidance for artificial cultivation.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Zongding Li, Yaoxuan Zhang, Dandan Xu, Liang Zhang, Fugang Xiao, Deguo Wang
Summary: This study successfully established a rapid, simple, sensitive, and specific Proofman-duplex-LMTIA identification method for distinguishing between Panax quinquefolium and Panax ginseng.
Article
Plant Sciences
Paul H. Goodwin
Summary: The endosphere of ginseng contains a variety of fungal, bacterial, archaeal and viral endophytes. Bacterial endophytes are primarily members of the Proteobacteria, Actinobacteria, Firmicutes and Bacteroidetes, and fungal endophytes are primarily members of the Ascomycota, Zygomycota and Basidiomycota. Little is known about archaea and viruses in ginseng plants. Root tissues have been found to have the highest abundance and diversity of bacterial and fungal endophytes, and their abundance often increases with root age. The metabolization of ginsenosides by endophytes suggests an adaptation of these microbes to the unique secondary metabolites found in ginseng tissues. Research on the benefits provided by endophytes has mainly focused on plant nutrition, growth promotion and disease resistance, with little emphasis on their ability to increase abiotic stress resistance. More studies are needed in the field, including trials with endophyte-treated plants, genomic/metagenomic analysis of endophytes, and investigations into the effects of endophytes on disease resistance and abiotic stress tolerance.
Review
Pharmacology & Pharmacy
Lanchun Liu, Jun Hu, Qiyuan Mao, Chao Liu, Haoqiang He, Xiaoshan Hui, Guang Yang, Peirong Qu, Wenjing Lian, Lian Duan, Yan Dong, Juhua Pan, Yongmei Liu, Qingyong He, Jun Li, Jie Wang
Summary: This paper elaborates on the current pharmacological effects of ginseng functional components in treating cardiovascular diseases, summarizes the adverse reactions of ginseng, and provides a list of Chinese patent medicines containing ginseng formula for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Xianhui Cheng, Xiaoying Li, Baosheng Liao, Jiang Xu, Lianghai Hu
Summary: This report highlights the use of strong cation exchange pretreatment to enhance the sensitivity of mass spectrometry detection in identifying proteins and peptides from Panax ginseng. The optimized strategy successfully identified a large number of proteins and endogenous peptides, providing valuable insights into the biological activities, metabolic processes, and ginsenoside biosynthesis pathways of ginseng.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoxue Fang, Manqi Wang, Xinteng Zhou, Huan Wang, Huaying Wang, Hongxing Xiao
Summary: This study investigated the effects of growth years on gene expression in cultivated ginseng and wild ginseng through transcriptome sequencing. The results showed that the growth years significantly affected gene expression in cultivated ginseng, especially in the MAPK signaling pathway and terpenoid backbone biosynthesis pathway. Moreover, the growth years had significant effects on genes related to ginsenoside synthesis in cultivated ginseng but had little influence on wild ginseng.
Article
Plant Sciences
Muhammad Irfan, Yuan Yee Lee, Ki-Ja Lee, Sung Dae Kim, Man Hee Rhee
Summary: This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG) and found that both extracts can inhibit platelet aggregation and calcium mobilization, indicating their potential for maintaining cardiovascular health and preventing platelet-related cardiovascular disorders.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jeongeui Hong, Kyoung Rok Geem, Jaewook Kim, Ick-Hyun Jo, Tae-Jin Yang, Donghwan Shim, Hojin Ryu
Summary: High temperature leads to reduced shoot and root growth in Panax ginseng, which is attributed to decreased cell elongation and cambium stem cell activity. RNA-seq data analysis reveals that the repression of stem and root growth is closely related to changes in photosynthesis, cell wall organization, cell wall loosening, and plant hormone signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Priyanka Chopra, Himanshu Chhillar, Yu-Jin Kim, Ick Hyun Jo, Sun Tae Kim, Ravi Gupta
Summary: This review summarizes the distribution, structural diversity, biotransformation, and functional attributes of ginsenosides in both plants and animals. It also discusses the biosynthesis of ginsenosides and their metabolism in the human body, along with the major regulators and stimulators. Moreover, it consolidates the biotechnological interventions to enhance ginsenoside biosynthesis and advancements in synthetic biosystems for efficient ginsenoside production.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Plant Sciences
Sejal Asija, Tanashvi Seth, Shahid Umar, Ravi Gupta
Summary: Crop production is affected by pathogens, but plants have evolved innate immunity to recognize pathogens and activate defense responses. In addition to well-established hormones like salicylic acid, jasmonic acid, and ethylene, polyamines (PAs) also play a key role in regulating plant immune responses. PAs synthesized during initial pathogen invasion contribute to resistance and are later catabolized to produce other signaling molecules for hypersensitive response.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Agronomy
Riyazuddin Riyazuddin, Kalpita Singh, Nadeem Iqbal, Nisha Nisha, Anita Rani, Manu Kumar, Nisha Khatri, Manzher H. Siddiqui, Yasheshwar, Sun Tae Kim, Feher Attila, Ravi Gupta
Summary: This review discusses the effects of iodine on plants, including its uptake and transportation, and the current understanding of its functioning as a biostimulant. Evidence supports the role of iodine in regulating gene expression, protein activity and structure, and maintaining ROS homeostasis in plants, leading to improved growth and stress responses.
Correction
Agronomy
Riyazuddin Riyazuddin, Kalpita Singh, Nadeem Iqbal, Nisha Nisha, Anita Rani, Manu Kumar, Nisha Khatri, Manzer H. Siddiqui, Yasheshwar, Sun Tae Kim, Feher Attila, Ravi Gupta
Review
Agronomy
M. Iqbal R. Khan, Sarika Kumari, Faroza Nazir, Risheek Rahul Khanna, Ravi Gupta, Himanshu Chhillar
Summary: Consistent climatic perturbations have increased global environmental concerns, especially the impacts of abiotic stresses on crop productivity. Rice is a staple food crop for the majority of the world's population. Plant hormones play an important role in mediating the growth and development of rice plants under optimal and stressful environments by activating signaling cascades to elicit adaptive responses. This review discusses the role of plant hormone-mediated abiotic stress tolerance in rice, potential crosstalk between plant hormones, and advancements in biotechnological initiatives to enhance rice resistance to abiotic stress.
Article
Biochemistry & Molecular Biology
Junko Shibato, Fumiko Takenoya, Michio Yamashita, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ai Kimura, Ichiro Takasaki, Motohide Hori, Seiji Shioda, Randeep Rakwal
Summary: This study aimed to understand the mechanism of neuronal outgrowth in PC12 cells treated with PACAP. Transcriptomic and proteomic analyses revealed several key regulators involved in neurite outgrowth, potentially involving cAMP signaling, PI3K-Akt signaling, and calcium signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Pooja Singh, Saumya Jaiswal, Ajayraj Kushwaha, Priya Gahlowt, Vipul Mishra, Durgesh Kumar Tripathi, Surendra Pratap Singh, Ravi Gupta, Vijay Pratap Singh
Summary: In this study, it was found that peroxynitrite is necessary for ethylene-mediated aerenchyma formation in rice roots under waterlogging conditions. Aerenchyma formation is crucial for the survival of plants under waterlogging stress, and the involvement of peroxynitrite in this process has been elusive. The findings highlight the role of peroxynitrite in ethylene-mediated aerenchyma formation and its potential for the development of waterlogging stress-tolerant rice varieties.
Article
Biochemical Research Methods
Ravi Gupta, Cheol Woo Min, Ju-Young Jung, Tae-Ho Ham, Jong-Seong Jeon, Lae-Hyeon Cho, Soon Wook Kwon, Sun Tae Kim
Summary: This study analyzed the proteomes of red and black rice seeds and compared them with white rice seeds. The results showed that red rice seeds are rich in β-carotene, while black rice seeds are rich in anthocyanins. Additionally, proteins associated with lignin and tocopherol biosynthesis were significantly increased in both red and black rice seeds. These findings provide insights into the molecular mechanisms underlying pigment accumulation in rice.
Editorial Material
Plant Sciences
Priya Gahlowt, Durgesh Kumar Tripathi, Francisco J. Corpas, Ravi Gupta, Vijay Pratap Singh
Summary: This study reveals that nitric oxide plays multifaceted roles in plants. It was found that NO produced in the shoot apex leads to S-nitrosation of transcription factor GT-1, which subsequently regulates the expression of the HSFA2 gene, resulting in thermotolerance in Arabidopsis thaliana.
TRENDS IN PLANT SCIENCE
(2023)
Review
Plant Sciences
Lirong Wei, Dacheng Wang, Ravi Gupta, Sun Tae Kim, Yiming Wang
Summary: Rice, as one of the most consumed foods globally, faces challenges in productivity and quality due to pathogenic microbes. Proteomics tools have been used to study protein level changes in rice-microbe interactions, leading to the identification of disease resistance-related proteins. Targeting proteins and pathways associated with the host's immune response is an efficient strategy for developing stress-resistant crops.
Article
Plant Sciences
Priya Gahlowt, Durgesh Kumar Tripathi, Samiksha Singh, Ravi Gupta, Vijay Pratap Singh
Summary: A recent discovery of a protein called HT1 has been found to cause continuous opening of stomata due to its kinase activity. However, the reversible interaction between MAP4/12 and HT1 protein acts as a CO2/bicarbonate sensor and inhibits HT1 kinase activity, resulting in the closing of stomata.
PLANT CELL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Samiksha Singh, Nawal Kishore Dubey, Durgesh Kumar Tripathi, Ravi Gupta, Vijay Pratap Singh
Summary: The study found that nitric oxide (NO) and hydrogen peroxide (H2O2) can alleviate the toxicity of hexavalent chromium (Cr(VI)) in wheat seedlings by regulating antioxidant enzymes and metabolites, as well as up-regulating high affinity sulfate transporter. They collectively controlled the occurrence of oxidative stress.
Article
Plant Sciences
Jinmi Yoon, Cheol Woo Min, Jiyoung Kim, Gibeom Baek, Dohyeon Kim, Jeong Woo Jang, Ravi Gupta, Sun Tae Kim, Lae-Hyeon Cho
Summary: Understanding the molecular mechanisms underlying early seed development is crucial for improving crop yield and quality. In this study, a comparative proteomic analysis of WT and osctps1-2 mutant rice seeds was conducted to investigate the molecular mechanism of early seed development. The results revealed that OsCTPS1 abundance increased at 1 DAP, and phosphorylation inhibition increased its stability. Additionally, reduced MCM protein levels and defects in seed development were observed in the mutant. These findings highlight the importance of post-transcriptional regulation in early seed development in rice.
Review
Biochemistry & Molecular Biology
Tanashvi Seth, Sejal Asija, Shahid Umar, Ravi Gupta
Summary: Plants activate a sophisticated signaling cascade in response to pests and pathogens, with lipids playing a crucial role in mediating these defense responses. Different types of lipids are involved in cell signaling during plant-pathogen interaction and each lipid has specific relevance and contributes to specific signaling cascades. Lipid biosynthetic enzymes, including phospholipases, are involved in the production of defense signaling molecules. Lipids participate in stress signaling by mediating signal transduction, acting as precursors for bioactive molecules, regulating ROS formation, and interacting with phytohormones.
Article
Chemistry, Applied
Ravi Gupta, Neha Kaushik, Manorma Negi, Nagendra Kumar Kaushik, Eun Ha Choi
Summary: This study explored the impact of plasma-activated water (PAW) on radish roots, revealing that PAW treatment can enhance antioxidant enzyme activity and the accumulation of functional compounds. The integration of proteomics and metabolomics analysis provided novel insights into the molecular mechanism underlying the growth and accumulation of these compounds in radish plants induced by PAW treatment.
