Article
Pharmacology & Pharmacy
Xiaoheng Li, Zhixin Peng, Lingling Jiang, Ping Zhang, Pin Yang, Zengqiang Yuan, Jinbo Cheng
Summary: Chronic stress exposure can lead to dysregulation of the immune system and activation of microglia, resulting in depression-like symptoms. The study found that Dlg1 knockout in microglia can alleviate depression-like behavior induced by chronic stress, by reversing microglial activation and morphological changes. This finding provides a potential target for the treatment of clinical depression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Xiao Fan Xu, Meng Meng Shi, Ming Ying Luo, Dan Dan Liu, Dong Ming Guo, Ling Chen, Xiao Lin Zhong, Yang Xu, Wen Yu Cao
Summary: Neuroinflammation plays a key role in the development of depression-like behaviors, and endoplasmic reticulum stress is suggested to collaborate with inflammation process to drive sustained neuroinflammation. This study found that targeting the PERK pathway can improve LPS-induced depression-like behaviors, indicating that targeting PERK pathway may be a promising antidepressant and anti-inflammatory drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Xiao Zhang, Xintong Wu, Li Li, Yi Zhang, Yihua Yu
Summary: Luteolin inhibits neuroinflammation and alleviates depression-like behavior by upregulating A20 and Nrf2.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Cell Biology
Ruqayya Afridi, Kyoungho Suk
Summary: Chronic stress is a significant risk factor for psychiatric diseases, particularly depression, as it causes cellular and structural changes that affect neurocircuitry and contribute to the development of depression. Recent studies have shown that microglial cells play a role in stress-induced depression through inflammatory activation. The exact pathways involved in stress-induced microglial activation are still unclear, but identifying these triggers can aid in the development of targeted therapies for depression.
Article
Neurosciences
Zhixin Peng, Xiaoheng Li, Jun Li, Yuan Dong, Yuhao Gao, Yajin Liao, Meichen Yan, Zengqiang Yuan, Jinbo Cheng
Summary: This study unveiled the role of Dlg1 in microglia, showing that knocking down Dlg1 can reduce microglial activation and alleviate LPS-induced depression-like behavior. This discovery provides a new potential therapeutic target for the clinical treatment of depression.
NEUROSCIENCE BULLETIN
(2021)
Review
Neurosciences
Julia N. Khantakova, Natalia P. Bondar, Elena V. Antontseva, Vasiliy V. Reshetnikov
Summary: Adverse factors during the neonatal period can affect the development of certain brain structures, leading to reduced cognitive abilities and increased risk of psychopathologies throughout an individual's lifespan. Neonatal immune activation-induced neuroinflammation may cause disturbances in neurotransmission, reprogramming of brain cells, and changes in stress reactivity, ultimately resulting in depressive-like behavior in adult males under aversive conditions with local inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Tianyuan Wang, Huandi Weng, Hongji Zhou, Zecheng Yang, Zhongyou Tian, Biao Xi, Yalan Li
Summary: This study aimed to investigate the protective effects and mechanisms of action of esketamine in postoperative depression (POD). The results showed that esketamine can significantly improve depression-like symptoms caused by anesthesia and surgery, and restore synaptogenesis in the medial prefrontal cortex (mPFC) that had been perturbed by inflammation. The anti-inflammatory effects of esketamine may be mediated by the BDNF/TrkB signaling pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, Research & Experimental
Ruisi Liu, Yueling Gong, Chenyi Xia, Yemin Cao, Cheng Zhao, Mingmei Zhou
Summary: Neuroinflammation plays a crucial role in the pathogenesis of depression, and itaconate, a metabolite secreted by macrophages, has potent anti-inflammatory and immunomodulatory effects that can improve depressive symptoms through various mechanisms. With the development of optimization and new delivery systems, itaconate has gained significantly improved application value and therapeutic potential. This article provides an overview of the immunomodulatory effects of itaconate and its promising application as a precursor of antidepressants in inflammatory depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Huili Jiang, Xianqi Long, Yu Wang, Xuhui Zhang, Lu Chen, Xinjing Yang, Bingcong Zhao, Ye Zhang, Yemao Chai, Tuya Bao
Summary: Emerging evidence suggests that stress-induced neuroinflammation plays a crucial role in the development of depression. Acupuncture has been shown to be effective and safe in preventing and treating depression. This study aimed to investigate the preventive effect of acupuncture and its mechanism in modulating neuroinflammation mediated by the toll-like receptor 4 (TLR4) signaling pathway. The findings suggest that acupuncture may exert its preventive effect by suppressing neuroinflammation through the TLR4 signaling pathway, which could be a promising treatment target for depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Yang Xu, Wei Li, Mengmeng Shi, Xiaofan Xu, Dongmin Guo, Zhenghai Liu, Ling Chen, Xiaolin Zhong, Wenyu Cao
Summary: Gonadotropin-releasing hormone (GnRH) mediates depression-like behaviors by modulating microglia function in the hippocampus. The antidepressant effect of GnRH depends on hippocampal GnRHR signaling, and peripheral GnRH treatment prevents microglia-mediated inflammation in the hippocampus. These findings provide insights into the function and cross-talk of GnRH in neuro-immune response.
Article
Immunology
Chenhui Ji, Yalin Tang, Yanyan Zhang, Congcong Li, Huazheng Liang, Lu Ding, Xiaohuan Xia, Lize Xiong, Xin-Rui Qi, Jialin C. Zheng
Summary: Glutaminase 1 (GLS1) has been found to play a crucial role in neuroinflammation, particularly in depression. By targeting GLS1 in microglia, it is possible to alleviate neuroinflammation and depression-like behaviors.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Rebecca G. Biltz, Samuel P. Swanson, Natalie Draime, Amara C. Davis, Wenyuan Yin, Ethan J. Goodman, Natalie R. Gallagher, Anindya Bhattacharya, John F. Sheridan, Jonathan P. Godbout
Summary: Chronic stress is associated with increased anxiety. Repeated social defeat in mice causes anxiety through the activation of neurons, reactive microglia, and accumulation of monocytes in the brain. The activation of P2X7 receptor on microglia plays a potential role in this process. Blocking P2X7 activation can attenuate neuroinflammation, monocyte accumulation, and anxiety-like behavior induced by repeated social defeat in male mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Edward S. Wickstead, Bradley T. Elliott, Sarah Pokorny, Christopher Biggs, Stephen J. Getting, Simon McArthur
Summary: Regulation of microglial activation by targeting formyl peptide receptor 2 (Fpr2) can reverse inflammation induced by bacterial inflammogen and has therapeutic potential for neuroinflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Lu Chen, Huili Jiang, Tuya Bao, Yu Wang, Hong Meng, Yang Sun, Pengfei Liu, Songxiao Quan, Wenshan Li, Simin Qi, Xiujun Ren
Summary: This study investigates the antidepressant mechanism of acupuncture in modulating neuroinflammation induced by HMGB1 in rats subjected to chronic restraint stress. The results suggest that acupuncture can alleviate depressive behavior and inhibit microglial activation and HMGB1 expression in the hippocampus, highlighting its role in stress-induced neuroinflammation in depression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Meichen Yan, Xuena Bo, Jingdan Zhang, Shuhan Liu, Xiaoheng Li, Yajin Liao, Qingshan Liu, Yong Cheng, Jinbo Cheng
Summary: Major depressive disorder (MDD) is a common psychiatric disorder that severely affects human life and health. The study found that bergapten (BG) can alleviate depression-like behavior induced by inflammation and protect against microglial activation and neuroinflammation. Thus, BG may serve as a new candidate drug for depression treatment.
EXPERIMENTAL NEUROLOGY
(2023)