Article
Biochemistry & Molecular Biology
Robertina Giacconi, Patrizia D'Aquila, Marta Balietti, Cinzia Giuli, Marco Malavolta, Francesco Piacenza, Laura Costarelli, Demetrio Postacchini, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali
Summary: Microbial dysbiosis leads to alterations in gut barrier and bacterial translocation, resulting in increased blood bacterial DNA that promotes peripheral and neuro inflammation and contributes to cognitive impairment. It also affects the production of brain-derived neurotrophic factor, which plays a role in the etiopathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biology
Zoya O. Serebrovska, Lei Xi, Lesya Tumanovska, Angela M. Shysh, Sergii Goncharov, Michael Khetsuriani, Taisia O. Kozak, Denis A. Pashevin, Victor E. Dosenko, Sergii V. Virko, Viktor A. Kholin, Oksana N. Grib, Natalie A. Utko, Egor Egorov, Anna O. Polischuk, Tetiana Serebrovska
Summary: The study investigated the effects of intermittent hypoxia-hyperoxia training (IHHT) on pro-inflammatory factors in healthy elderly individuals and patients with early signs of Alzheimer's disease (AD). IHHT was found to improve cognitive function, potentially through upregulating circulating levels of inflammatory markers and triggering cellular adaptive reprogramming.
Article
Nutrition & Dietetics
Xuan Wang, Tiantian Li, Hongrui Li, Dajun Li, Xianyun Wang, Ai Zhao, Wannian Liang, Rong Xiao, Yuandi Xi
Summary: Inflammation is an important mechanism of cognitive dysfunction. Systemic immune inflammation index (SII) and system inflammation response index (SIRI) are two blood inflammatory markers related to cognitive impairment and other chronic diseases. Dietary inflammatory index (DII), used to estimate the overall inflammatory potential of diet, may also be related to mild cognitive impairment (MCI). This study aimed to explore the relationship between SII, SIRI, and DII, and their role in MCI in elderly individuals.
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Jiachen Chen, Margaret F. Doyle, Yuan Fang, Jesse Mez, Paul K. Crane, Phoebe Scollard, Claudia L. Satizabal, Michael L. Alosco, Wei Qiao Qiu, Joanne M. Murabito, Kathryn L. Lunetta
Summary: This study investigates the associations between inflammatory protein biomarkers and cognitive function as well as incident dementia outcomes. Higher levels of certain proteins are associated with worse executive function and language domain scores. Stratified analyses suggest differential effects between APOE e2 and e4 carriers, with e4 carriers showing associations with executive function and memory domains, and e2 carriers showing associations with the visuospatial domain. Higher levels of TNFB and CDCP1 are associated with increased risks of incident all-cause and AD dementia.
Article
Geriatrics & Gerontology
Joel Eyamu, Wuon-Shik Kim, Kahye Kim, Kun Ho Lee, Jaeuk U. Kim
Summary: This study examined cognitive deficits and behavioral changes in patients with mild cognitive impairment (MCI) using prefrontal selective attention event-related potential (ERP) recorded from a prefrontal two-channel electroencephalography (EEG) device. The results showed that patients with MCI had slower information processing abilities and poorer task execution compared to cognitively normal adults. Multiple logistic regression analysis confirmed the association between some ERP and behavioral measures with MCI prevalence, independent of demographic and neuropsychological factors. There was a relationship observed between neuropsychological scores, ERP, and behavioral measures.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qin
Summary: By mapping the region-specific nonlinear atrophic trajectory of the whole cerebrum from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), this study found that the atrophic trajectory is quadratic accelerated, especially in the superior temporal pole, caudate, and hippocampus. Furthermore, the study revealed that APOE ε4 carriers and younger patients had faster atrophic rates in specific regions. Lastly, the identified region-specific biomarkers were able to predict AD conversion within 10 years.
Article
Clinical Neurology
Shiloh L. Echevarria-Cooper, Emily H. Ho, Richard C. Gershon, Sandra Weintraub, Thorsten Kahnt
Summary: Olfactory decline is associated with aging, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia. The National Institutes of Health Toolbox Odor Identification Test (NIHTB-OIT) can distinguish between these clinical categories. The scores of NIHTB-OIT decrease with age and are lower for aMCI and ADd participants compared to NC participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carol D. SanMartin, Felipe Salech, Daniela Paz Ponce, Jorge Concha-Cerda, Esteban Romero-Hernandez, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Barbara Bruna, Jamileth More, Maria I. Behrens
Summary: Epidemiological studies find that having a history of cancer or Alzheimer's Disease (AD) can protect against the development of the other. The underlying mechanism for this mutual protection is unknown. However, research suggests that PBMCs of individuals with aMCI and AD have increased susceptibility to oxidative cell death, while a history of cancer is associated with increased resistance to cell death caused by oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Li, Yinhua Zhou, Zhaofan Luo, Rixin Tang, Yuxuan Sun, Qiangsheng He, Bin Xia, Kuiqing Lu, Qinghua Hou, Jinqiu Yuan
Summary: This study aims to construct a lipid score system to predict the risk of progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The results showed that the lipid score system based on serum lipidomics can accurately predict the progression risk from MCI to AD.
Article
Geriatrics & Gerontology
Mark Sanderson-Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen
Summary: Cognitive practice effects (PEs) can impact the diagnosis and progression prediction of MCI, increasing prevalence, reducing reversion rates, and increasing the risk of dementia. Accounting for PEs can improve diagnostic accuracy and the prediction ability of dementia in MCI diagnoses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Clinical Neurology
Bernabe Bustos, Kimberley Billingsley, Cornelis Blauwendraat, J. Raphael Gibbs, Ziv Gan-Or, Dimitri Krainc, Andrew B. Singleton, Steven J. Lubbe
Summary: Bustos et al. conducted the first genome-wide meta-analysis of common short tandem repeats (STRs) in Parkinson's disease and identified four new independent risk factors. They found that STRs contribute to the heritability of Parkinson's disease and that STR-associated genes are enriched in Parkinson's disease-relevant tissues and pathways.
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Medicine, General & Internal
Eleni Poptsi, Despina Moraitou, Emmanouil Tsardoulias, Andreas L. Symeonidis, Vasileios Papaliagkas, Magdalini Tsolaki
Summary: The aim of this study was to extend the R4Alz battery by adding extra episodic memory tasks and cognitive control tasks, in order to improve its discriminant validity. The results showed that the tasks in the R4Alz-R battery were able to effectively discriminate between healthy adults, subjective cognitive decline, and mild cognitive impairment patients. Therefore, the R4Alz-R battery appears to be a useful tool for early diagnosis, as it can objectively evaluate the condition of minor neurocognitive diseases.
Article
Neurosciences
Anna Inguanzo, Konstantinos Poulakis, Rosaleena Mohanty, Christopher G. Schwarz, Scott A. Przybelski, Patricia Diaz-Galvan, Val J. Lowe, Bradley F. Boeve, Afina W. Lemstra, Marleen van de Beek, Wiesje van der Flier, Frederik Barkhof, Frederic Blanc, Paulo Loureiro de Sousa, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Zuzana Nedelska, Jakub Hort, Barbara Segura, Carme Junque, Ketil Oppedal, Dag Aarsland, Eric Westman, Kejal Kantarci, Daniel Ferreira
Summary: Using MRI data, we identified three subtypes of Dementia with Lewy bodies (DLB): older subtype with reduced cortical GM volumes and worse cognition, subtype with low GM volumes in fronto-occipital regions, and a younger subtype with the highest cortical GM volumes, lower GM volumes in basal ganglia, and cognitive fluctuations. These subtypes have implications for clinical practice, research, and treatment decisions.
NPJ PARKINSONS DISEASE
(2023)
Review
Biology
Paschalis Devranis, Emilia Vassilopoulou, Vasileios Tsironis, Panagiotis Marios Sotiriadis, Michail Chourdakis, Michalis Aivaliotis, Magdalini Tsolaki
Summary: This study systematically reviewed the evidence of three dietary patterns, the Mediterranean diet, the ketogenic diet, and the MIND diet, for the prevention of cognitive decline. The analysis showed that all three dietary interventions could slow the rate of cognitive decline.
Editorial Material
Geriatrics & Gerontology
Virginia Boccardi, Patrizia Mecocci
Summary: The concept of intermediate care is increasingly recognized in Italy as a critical strategy to improve healthcare quality and integration across different settings. Person-tailored care is a key challenge, requiring a shift towards a holistic approach that prioritizes individual preferences and values. This necessitates greater collaboration, communication, and innovation in care delivery, including the use of technology for remote monitoring. Despite challenges, intermediate care offers significant opportunities to enhance care quality, reduce costs, and promote social cohesion and community engagement.
Correction
Clinical Neurology
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Health Care Sciences & Services
Vaitsa Giannouli, Magdalini Tsolaki
Summary: This study aimed to investigate the influence of comorbid depression in mixed dementia patients on financial capacity. The results showed that financial capacity was significantly impaired in mixed dementia patients with coexisting depression, highlighting the importance of addressing this issue in neuropsychological assessments to prevent financial exploitation.
Article
Neurosciences
Bruno Mario Cesana, Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Alfonso Ciccone, Emmanuel Cognat, Andrea Fabbo, Sara Fascendini, Giovanni B. Frisoni, Lutz Froelich, Maria Cristina Jori, Patrizia Mecocci, Paola Merlo, Oliver Peters, Carlo Alberto Defanti
Summary: This study conducted confirmatory and exploratory factor analyses on the Cohen-Mansfield Agitation Inventory (CMAI) to assess agitation in dementia patients. The results suggested that the current three-factor structure was not confirmed, and a new four-factor structure based on clinical criteria was proposed for a more accurate evaluation of symptoms.
Article
Neurosciences
Marianna Tsatali, Despina Moraitou, Evgenia Sakka Boza, Magdalini Tsolaki
Summary: This study aimed to investigate the multifactorial impact of the second lockdown measures and the one-year period after the second lockdown on the cognition, mood, and daily function of older adults with mild cognitive impairment (MCI) and Alzheimer's disease dementia (ADD) in Greece. The results showed that patients who participated in digital non-pharmacological interventions during the lockdown did not experience significant cognitive and functional deterioration, except for verbal memory as well as visual scanning and information processing.
Article
Health Care Sciences & Services
Aristi Alopoudi, Marina Makri, Batuhan Alisoglu, Abdullah Dogan, Antonino Imbesi, Mehmetcan Karakoyun, Alexis Lacapelle, Marco Aurelio Navarro Roux, Alexia Pissa, Magda Tsolaki
Summary: This paper describes the steps of developing and assessing a non-pharmacological intervention, specifically a Serious Game, with the goal of improving eight cognitive skills in adults with Intellectual Disabilities. Currently, there is a lack of a single tool that targets various cognitive skills as well as a broader spectrum of disorders.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Psychology, Multidisciplinary
Styliani Olympia Tsormpatzoudi, Despina Moraitou, Vasileios Papaliagkas, Christos Pezirkianidis, Magda Tsolaki
Summary: This study explored the relationship between cognitive state, subjective wellbeing factors, negative psychological outcomes, and psychological resilience. The findings suggest that individuals with late MCI experience higher levels of negative psychological outcomes, poorer psychological resilience, and lower levels of subjective wellbeing compared to early MCI and healthy participants. These findings can be used to develop psychological interventions to enhance resilience and support brain health in older adults at risk of neurodegeneration.
BEHAVIORAL SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Maria Sofologi, Evaggelia Foutsitzi, Aphrodite Papantoniou, Georgios Kougioumtzis, Harilaos Zaragas, Magdalini Tsolaki, Despina Moraitou, Georgia Papantoniou
Summary: This study investigated the relationships among high school teachers' tacit knowledge, professional development, and metacognitive knowledge related to teaching practices. The findings showed that there were associations between teachers' metacognitive knowledge about classroom management difficulties and the use of modern methods and technologies, as well as certain tacit knowledge strategies. Additionally, teachers' professional development, particularly their ability to interact in socially heterogeneous groups, was found to affect their tacit knowledge strategies.
JOURNAL OF INTELLIGENCE
(2023)
Article
Geriatrics & Gerontology
Anna Rennie, Urban Ekman, John Wallert, J-Sebastian Muehlboeck, Maria Eriksdotter, Lars-Olof Wahlund, Daniel Ferreira, Eric Westman
Summary: This study compared three different approaches to subgroup SCI and MCI patients and investigated their capacity to disentangle cognitive and biomarker heterogeneity. The three approaches identified individuals with different biomarkers and captured some neuropsychological differences. The study helps advance understanding of the clinical and biological heterogeneity within SCI and MCI.
NEUROBIOLOGY OF AGING
(2023)
