A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

(2018) Tenielle Porter et al.   Scientific Reports

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

(2018) Henna Martiskainen et al.   JOURNAL OF ALZHEIMERS DISEASE

Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study

(2018) Tenielle Porter et al.   JOURNAL OF ALZHEIMERS DISEASE

MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease

(2017) Tomoko Sao et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

Gene-based aggregate SNP associations between candidate AD genes and cognitive decline

(2016) Jasmine Nettiksimmons et al.   AGE

Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up

(2016) Jessica R. Marden et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

(2016) Eva Louwersheimer et al.   Alzheimers & Dementia

Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study

(2016) Jan Bressler et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer’s Disease

(2016) Vincent Chouraki et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease

(2016) Burcu F. Darst et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study

(2016) Samantha C Burnham et al.   LANCET NEUROLOGY

Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment

(2016) A Lacour et al.   MOLECULAR PSYCHIATRY

Association of genetic risk factors with cognitive decline: the PATH through life project

(2016) Shea J. Andrews et al.   NEUROBIOLOGY OF AGING

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

(2016) Michelle K. Lupton et al.   NEUROBIOLOGY OF AGING

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

(2016) Elizabeth C. Mormino et al.   NEUROLOGY

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Advanced brain aging: relationship with epidemiologic and genetic risk factors and overlap with Alzheimer disease atrophy patterns

(2016) M Habes et al.   Translational Psychiatry

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ 42

(2015) Kristel Sleegers et al.   Alzheimers & Dementia

Common polygenic variation enhances risk prediction for Alzheimer’s disease

(2015) Valentina Escott-Price et al.   BRAIN

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

(2015) G Davies et al.   MOLECULAR PSYCHIATRY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease

(2015) Minerva M. Carrasquillo et al.   NEUROBIOLOGY OF AGING

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease

(2015) Yen Ying Lim et al.   NEUROBIOLOGY OF AGING

Comparison of MR-less PiB SUVR quantification methods

(2015) Pierrick Bourgeat et al.   NEUROBIOLOGY OF AGING

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease

(2014) Y Y Lim et al.   MOLECULAR PSYCHIATRY

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

The Preclinical Alzheimer Cognitive Composite

(2014) Michael C. Donohue et al.   JAMA Neurology

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Screening for predementia AD: Time-dependent operating characteristics of episodic memory tests

(2013) C. A. Derby et al.   NEUROLOGY

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease

(2012) E. Rodríguez-Rodríguez et al.   JOURNAL OF NEURAL TRANSMISSION

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

The Association between a Polygenic Alzheimer Score and Cortical Thickness in Clinically Normal Subjects

(2011) Mert R. Sabuncu et al.   CEREBRAL CORTEX

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

(2010) Alessandro Biffi   ARCHIVES OF NEUROLOGY

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

(2009) Kathryn A Ellis et al.   INTERNATIONAL PSYCHOGERIATRICS

Effect of COMT val158met genotype on cognition and personality

(2008) A.J. Sheldrick et al.   EUROPEAN PSYCHIATRY

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

(2008) ELLEN GROBER et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

(2008) A. C. Barbosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA