Review
Cell Biology
Alessandro Gialluisi, Aurelia Santoro, Alfonsina Tirozzi, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Claudio Franceschi, Licia Iacoviello
Summary: This review examines the evidence for partial overlap among different estimators of biological age, looking at both epidemiological and genetic perspectives. The findings suggest shared and independent influences on mortality risk from various aging clocks, with potential implications for future anti-aging interventions.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Lorena Lorefice, Giuseppe Fenu, Marzia Fronza, Federica Murgia, Jessica Frau, Giancarlo Coghe, Maria Antonietta Barracciu, Luigi Atzori, Stefano Angioni, Eleonora Cocco
Summary: This study investigates the influence of menopause on multiple sclerosis (MS), showing that menopause is associated with MS progression and brain atrophy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Vincent Planche, Vincent Bouteloup, Jean-Francois Mangin, Bruno Dubois, Julien Delrieu, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Audrey Gabelle, Matthieu Ceccaldi, Cedric Annweiler, Pierre Krolak-Salmon, Marie-Odile Habert, Clara Fischer, Marie Chupin, Yannick Bejot, Olivier Godefroy, David Wallon, Mathilde Sauvee, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Francois Tison, Genevieve Chene, Carole Dufouil
Summary: In individuals attending memory clinics, categorization of atrophy subtypes predicted different patterns of cognitive decline and rates of conversion to distinct etiologies of dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Medicine, General & Internal
Dongyu Fan, Huiyun Li, Dongwan Chen, Yang Chen, Xu Yi, Heng Yang, Qianqian Shi, Fangyang Jiao, Yi Tang, Qiming Li, Fangyang Wang, Shunan Wang, Rongbing Jin, Fan Zeng, Yanjiang Wang
Summary: The study found no significant differences in cortical standard uptake ratios, grey/white ratio, and brain atrophy indices between hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion, suggesting that chronic hypoperfusion may not directly induce cerebral beta-amyloid deposition and neurodegeneration in humans due to large vessel stenosis.
CHINESE MEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Benoit Sauty, Stanley Durrleman
Summary: Alzheimer's Disease (AD) disproportionately affects women and individuals with the APOE-epsilon 4 susceptibility gene. This study aimed to understand the influence of these two risk factors on brain atrophy in AD and healthy aging. The results showed that women experience more severe brain atrophy in the later stages of the disease, and the APOE genotype accelerates brain atrophy in AD patients. These findings have important implications for targeted interventions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Andrei Irimia, Van Ngo, Nikhil N. Chaudhari, Fan Zhang, Shantanu H. Joshi, Anita N. Penkova, Lauren J. O'Donnell, Nasim Sheikh-Bahaei, Xiaoyu Zheng, Helena C. Chui
Summary: This study found that cerebral microbleeds in mTBI patients are associated with white matter degradation and cognitive decline, with male sex and older age as significant risk factors for larger reductions. The findings indicate a significant positive correlation between CMBs and changes in cognitive functions, suggesting the need for long-term cognitive assessment in mTBI patients.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Romain Icick, Alexey Shadrin, Borge Holen, Naz Karadag, Aihua Lin, Guy Hindley, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Collier Hoegh, Weiqiu Cheng, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Trine Vik Lagerberg, Olav B. Smeland, Ole A. Andreassen
Summary: Alcohol use disorder (AUD) has high comorbidity rates with other mental disorders. This study aimed to understand the genetic architecture of this comorbidity by studying intermediate traits that show genetic correlation with AUD. The results revealed shared and unique polygenicity between AUD, alcohol consumption (AC), and mood instability (MOOD), suggesting new mechanisms for the comorbidity of AUD with mood disorders.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory Kuchcinski, Lucas Patin, Renaud Lopes, Melanie Leroy, Xavier Delbeuck, Adeline Rollin-Sillaire, Thibaud Lebouvier, Yi Wang, Pascal Spincemaille, Thomas Tourdias, Lotfi Hacein-Bey, David Devos, Florence Pasquier, Xavier Leclerc, Jean-Pierre Pruvo, Sebastien Verclytte
Summary: This study aimed to investigate the brain iron distribution patterns in subtypes of early-onset Alzheimer's disease (EOAD) using quantitative susceptibility mapping (QSM). The results showed that EOAD patients had higher QSM values in deep gray nuclei and limbic structures compared to controls. Among EOAD subtypes, HpSp(MRI) had the highest QSM values in deep gray nuclei, while LPMRI had the highest QSM values in limbic structures. Iron overload in deep gray nuclei could help identify patients with atypical presentation of Alzheimer's disease.
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Jennifer S. Albrecht, Raquel C. Gardner, Douglas Wiebe, Amber Bahorik, Feng Xia, Kristine Yaffe
Summary: The association between traumatic brain injury (TBI) and risk for Alzheimer disease and related dementias (ADRD) has been investigated in multiple studies, but the reported effect sizes vary widely. This study highlights the importance of selecting the appropriate comparison group in estimating the effect of TBI on ADRD risk, as it significantly impacts the estimated effect.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Endocrinology & Metabolism
Muhammad Arif Aslam, Eun Bi Ma, Joo Young Huh
Summary: Sarcopenia, a geriatric disorder characterized by a decline in muscle mass and function, is associated with adverse health outcomes. This review consolidates knowledge on the genetic factors influencing sarcopenia and emphasizes their interaction with environmental factors. It aims to inform the development of therapeutic interventions for sarcopenia.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Genetics & Heredity
Hamzeh M. Tanha, Anita Sathyanarayanan, Dale R. Nyholt
Summary: The study utilized genome-wide association studies (GWASs) to investigate the genetic overlap and causality between blood metabolite levels and migraine risk. Significant genetic overlap was found between migraine and 44 metabolites, with shared genetic influences identified at eight independent genomic loci across different chromosomes. The findings suggest alterations in metabolite levels in individuals with migraine, with fatty acids playing a potentially protective role against migraine and a specific lipid metabolite identified as a potential therapeutic target for migraine.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Review
Cell Biology
Kun Jia, Heng Du
Summary: Advanced age is the primary risk factor for aging-related brain disorders like Alzheimer's disease, with the detailed mechanisms linking aging and AD still unclear. Recent studies have highlighted the mitochondrial hypothesis in brain aging and AD, particularly the role of mitochondrial permeability transition pore.
Article
Clinical Neurology
Si-Jia Chen, Bang-Sheng Wu, Yi-Jun Ge, Shi-Dong Chen, Ya-Nan Ou, Qiang Dong, Jianfeng Feng, Wei Cheng, Jin-Tai Yu
Summary: Using MRI data from UK Biobank, we identified significant genomic loci for CC FA and volume and identified pathways and cell types related to these traits.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Young Ju Kim, Alice Hahn, Yu Hyun Park, Duk L. Na, Juhee Chin, Sang Won Seo
Summary: This study developed a composite score that can sensitively detect the amyloid-beta (A beta)-related cognitive trajectory of preclinical AD using Korean data. The score may contribute to reduction in time and financial burden when monitoring A beta-related cognitive decline and therapeutic efficacy of the disease-modifying agents specifically targeting A beta in secondary prevention trials.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Psychology, Biological
Yi-Jun Ge, Bang-Sheng Wu, Yi Zhang, Shi-Dong Chen, Ya-Ru Zhang, Ju-Jiao Kang, Yue-Ting Deng, Ya-Nan Ou, Xiao-Yu He, Yong-Li Zhao, Kevin Kuo, Qing Ma, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Jian-Feng IMAGEN Consortium, Jian-Feng Feng, Lan Tan, Qiang Dong, Gunter Schumann, Wei Cheng, Jin-Tai Yu
Summary: This study investigates the genetic basis of ventricular morphology and its overlap with neuropsychiatric traits. The researchers identify unique loci and candidate genes associated with ventricular morphology and reveal the enrichment of these genes in biological processes and disease pathogenesis. They also explore the age-dependent genetic associations of ventricular-trait-associated loci in neurodevelopmental and neurodegenerative processes.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Clinical Neurology
Christina S. Dintica, Mohamad Habes, Guray Erus, Eric Vittinghoff, Christos Davatzikos, Ilya M. Nasrallah, Lenore J. Launer, Stephen Sidney, Kristine Yaffe
Summary: We found that elevated blood pressure from early to mid-adulthood is associated with advanced brain aging in mid-life, even if the blood pressure is below the clinical cutoffs.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biology
Danni Tu, Manu S. Goyal, Jordan D. Dworkin, Samuel Kampondeni, Lorenna Vidal, Eric Biondo-Savin, Sandeep Juvvadi, Prashant Raghavan, Jennifer Nicholas, Karen Chetcuti, Kelly Clark, Timothy Robert-Fitzgerald, Theodore D. Satterthwaite, Paul Yushkevich, Christos Davatzikos, Guray Erus, Nicholas J. Tustison, Douglas G. Postels, Terrie E. Taylor, Dylan S. Small, Russell T. Shinohara
Summary: A central challenge in medical imaging studies is to extract biomarkers that can characterize disease pathology or outcomes. This paper presents a fully automated framework for translating radiological diagnostic criteria into image-based biomarkers, with excellent classification performance.
Review
Clinical Neurology
Jon B. Toledo, Carla Abdelnour, Rimona S. Weil, Daniel Ferreira, Federico Rodriguez-Porcel, Andrea Pilotto, Kathryn A. Wyman-Chick, Michel J. Grothe, Joseph P. M. Kane, Angela Taylor, Arvid Rongve, Sonja Scholz, James B. Leverenz, Bradley F. Boeve, Dag Aarsland, Ian G. McKeith, Simon Lewis, Iracema Leroi, John P. Taylor
Summary: Dementia with Le bodies (DLB) is clinically characterized by visual hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and parkinsonism. However, neuropathological studies have shown the coexistence of Alzheimer's disease, TAR DNA-binding protein 43 (TDP-43), and cerebrovascular pathologies in DLB cases. These co-pathologies should be taken into consideration in clinical trials for DLB individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Ana I. Maldonado, Hind A. Beydoun, Leslie I. Katzel, Christos Davatzikos, Rao P. Gullapalli, Stephen L. Seliger, Guray Erus, Michele K. Evans, Alan B. Zonderman, Shari R. Waldstein
Summary: The link between plasma neurofilament light chain (NfL) and dementia may be mediated through white matter integrity (WMI). This study found that higher plasma NfL levels were associated with increased global and frontal white matter trace (TR) in middle-aged adults, particularly among males and White individuals. Additionally, African American adults showed a relationship between NfL and greater left temporal lobe TR.
NEUROBIOLOGY OF AGING
(2023)
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Article
Neurosciences
Di Wang, Nicolas Honnorat, Peter T. Fox, Kerstin Ritter, Simon B. Eickhoff, Sudha Seshadri, Mohamad Habes
Summary: We compared three heatmap methods derived from deep neural networks and SVM activation patterns to analyze structural MRI scans of subjects with Alzheimer's disease. Our results showed that all three heatmap methods were able to capture brain regions more accurately than SVM activation patterns, and the Integrated Gradients method had the best overlap with the independent meta-analysis.
Article
Biochemistry & Molecular Biology
Dominic B. Dwyer, Ganesh B. Chand, Alessandro Pigoni, Adyasha Khuntia, Junhao Wen, Mathilde Antoniades, Gyujoon Hwang, Guray Erus, Jimit Doshi, Dhivya Srinivasan, Erdem Varol, Rene S. Kahn, Hugo G. Schnack, Eva Meisenzahl, Stephen J. Wood, Chuanjun Zhuo, Aristeidis Sotiras, Russell T. Shinohara, Haochang Shou, Yong Fan, Maristela Schaulfelberger, Pedro Rosa, Paris A. Lalousis, Rachel Upthegrove, Antonia N. Kaczkurkin, Tyler M. Moore, Barnaby Nelson, Raquel E. Gur, Ruben C. Gur, Marylyn D. Ritchie, Theodore D. Satterthwaite, Robin M. Murray, Marta Di Forti, Simone Ciufolini, Marcus V. Zanetti, Daniel H. Wolf, Christos Pantelis, Benedicto Crespo-Facorro, Geraldo F. Busatto, Christos Davatzikos, Nikolaos Koutsouleris, Paola Dazzan
Summary: Using machine learning, researchers found that schizophrenia can be decomposed into two volumetric subgroups with distinct neuroanatomical characteristics: a 'lower brain volume' subgroup and a 'higher striatal volume' subgroup. These subgroups were already present at the first episode of psychosis and were associated with different clinical presentations and remission outcomes. The findings suggest that these subgroups may be important in understanding the underlying mechanisms of schizophrenia and could be targeted in future treatment trials.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
C'iana P. Cooper, Andrea T. Shafer, Nicole M. Armstrong, Yang An, Guray Erus, Christos Davatzikos, Luigi Ferrucci, Peter R. Rapp, Susan M. Resnick
Summary: This study investigated the association between cerebellar volume and verbal learning and memory. The findings suggest that decline in cerebellar white matter volume is associated with decline in verbal memory, while preserved cerebellar gray matter volume is associated with less decline in verbal learning and memory. These results indicate that the association between cerebellar volume and verbal learning and memory is age-dependent and regionally specific.
Article
Neurosciences
Zhen Zhou, Hongming Li, Dhivya Srinivasan, Ahmed Abdulkadir, Ilya M. Nasrallah, Junhao Wen, Jimit Doshi, Guray Erus, Elizabeth Mamourian, Nick R. Bryan, David A. Wolk, Lori Beason-Held, Susan M. Resnick, Theodore D. Satterthwaite, Christos Davatzikos, Haochang Shou, Yong Fan
Summary: In this study, a brain age prediction model of multiscale functional connectivity measures was built using a large fMRI dataset. The study found that multiscale functional connectivity measures were more informative than single-scale measures for brain age prediction. Data harmonization significantly improved the predictive performance, and harmonization in the tangent space of functional connectivity measures worked better than in their original space. Additionally, the brain age gap derived from the prediction model was significantly correlated with clinical and cognitive measures.
Article
Clinical Neurology
Joshua K. Wong, Janine Melo Lobo Jofili Lopes, Wei Hu, Anson Wang, Ka Loong Kelvin Au, Tamara Stiep, Jessica Frey, Jon B. Toledo, Robert S. Raike, Michael S. Okun, Leonardo Almeida
Summary: This study compares the safety and tolerability of active recharge biphasic DBS (bDBS) with conventional clinical DBS (clinDBS) in patients with primary dystonia. Results show that bDBS is safe and well-tolerated in all 10 subjects, with greater immediate improvement compared to clinDBS after 4 hours of stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Malte Klingenberg, Didem Stark, Fabian Eitel, Celine Budding, Mohamad Habes, Kerstin Ritter, Alzheimers Dis Neuroimaging Initiat
Summary: This study trained a convolutional neural network using a balanced dataset to detect Alzheimer's disease. The results showed that the machine learning classifier had different performance for men and women, indicating the presence of sex bias. The findings emphasize the importance of examining and reporting classifier performance across population subgroups to ensure algorithmic fairness.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Tanweer Rashid, Karl Li, Jon B. Toledo, Ilya Nasrallah, Nicholas M. Pajewski, Sudipto Dolui, John Detre, David A. Wolk, Hangfan Liu, Susan R. Heckbert, R. Nick Bryan, Jeff Williamson, Christos Davatzikos, Sudha Seshadri, Lenore J. Launer, Mohamad Habes
Summary: This study suggests that intensive blood pressure (BP) treatment, compared with standard treatment, was associated with a slower increase of white matter lesions (WMLs) and improved diffusion tensor imaging, fractional anisotropy (FA), and cerebral blood flow (CBF) changes in several vulnerable brain regions.
Article
Computer Science, Artificial Intelligence
Hangfan Liu, Michel J. Grothe, Tanweer Rashid, Miguel A. Labrador-Espinosa, Jon B. Toledo, Mohamad Habes
Summary: In this paper, a method is proposed to improve clustering of subjects in neuroimaging applications by exploiting the underlying clusters of features and suppressing noise through nonnegative matrix tri-factorization and adaptive regularization. Experimental results on synthetic data and real magnetic resonance imaging (MRI) data demonstrate the superiority of the proposed method.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTATIONAL INTELLIGENCE
(2023)
Article
Geriatrics & Gerontology
May A. Beydoun, Nicole Noren Hooten, Hind A. Beydoun, Jordan Weiss, Ana I. Maldonado, Leslie I. Katzel, Christos Davatzikos, Rao P. Gullapalli, Stephen L. Seliger, Guray Erus, Michele K. Evans, Alan B. Zonderman, Shari R. Waldstein
Summary: Elevated levels of plasma neurofilament light chain (NfL) have been found to be associated with dementia, but the underlying mechanisms remain unknown. This study examined the relationship between plasma NfL and brain structural markers using magnetic resonance imaging (MRI), revealing associations with white matter lesion volume, hippocampal volume, and brain volumes. These findings suggest that plasma NfL could serve as a potential biomarker for predicting future brain pathologies in middle-aged adults.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Qu Tian, Brendan A. Mitchell, Guray Erus, Christos Davatzikos, Ruin Moaddel, Susan M. Resnick, Luigi Ferrucci
Summary: Lipids are important for brain structure and function, and studies show that men experience greater brain atrophy than women with aging. This study investigated the sex-specific associations between circulating lipids and brain atrophy in a sample of cognitively normal older adults. Results revealed sex differences in the associations between specific lipid profiles and accelerated brain aging. The findings suggest the need for further investigation into the mechanisms underlying these sex-specific lipid profiles.
NEUROBIOLOGY OF AGING
(2023)