Article
Biotechnology & Applied Microbiology
Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha, Xueqi Li
Summary: This study demonstrated that Ivabradine attenuated myocardial infarction in rats by enhancing autophagy, and the PI3K/AKT/mTOR/p70S6K pathway might be involved in this process. Activation of autophagy by Ivabradine could be a potential therapeutic strategy for the treatment of myocardial infarction.
Article
Biochemistry & Molecular Biology
Kai Xu, Yuzhe He, Safwat Adel Abdo Moqbel, Xing Zhou, Lidong Wu, Jiapeng Bao
Summary: This study investigated the role of SIRT3 in osteoarthritis pathophysiology and found that SIRT3 serves as a protective agent against OA by inhibiting the PI3K/Akt/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Ai-Yuan Xiu, Qian Ding, Zhen Li, Chun-Qing Zhang
Summary: Doxazosin inhibits autophagy by activating the PI3K/Akt/mTOR signaling pathway, attenuating liver fibrosis. It also blocks HSC proliferation and migration, inducing cell apoptosis in a concentration-dependent manner. Additionally, doxazosin activates the PI3K/Akt/mTOR pathway which regulates fibrosis, autophagy, and apoptosis in HSCs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Meixu Wan, Kunkun Yin, Jing Yuan, Shiyan Ma, Qing Xu, Dekun Li, Hui Gao, Xiangbo Gou
Summary: The Yiqi Fumai lyophilized injection (YQFM) demonstrated protective effects in cardiac hypertrophy by inhibiting cardiomyocyte apoptosis, regulating autophagy pathway, and activating the PI3K/AKT/mTOR pathway to attenuate cardiac hypertrophy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Junying Gan, Wenhua Li, Meng Tang, Yuying Xue
Summary: This study found that AgNPs can induce cytotoxicity in HT22 cells through autophagy and apoptosis pathways mediated by the PI3K/AKT/mTOR signaling pathway. These results provide experimental evidence and explanation for the potential neurotoxicity triggered by AgNPs in vitro.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Han, Lisong Wang, Huayi Lv, Jiajia Liu, Yiran Dong, Lei Shi, Qingshan Ji
Summary: The study showed that EphA2 can enhance cell viability and reduce apoptosis in H2O2-treated lens epithelial cells by inhibiting autophagy, possibly through activating the PI3K/Akt/mTOR pathway.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Environmental Sciences
Hongmin Lu, Kai Yin, Heng Su, Dongxu Wang, Yue Zhang, Lulu Hou, Jun Bo Li, Yu Wang, Mingwei Xing
Summary: This study found that polystyrene microplastics (PS-MPs) can cause lung injury in broiler chickens, leading to oxidative stress through inhibition of the PTEN/PI3K/AKT pathway and induction of autophagy and cell apoptosis. These results are of great significance to the toxicological study of PS-MPs and the protection of the ecosystem.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Integrative & Complementary Medicine
Du Bing-Xin, Lin Pei, Lin Jun
Summary: EGCG and ECG induce apoptosis through the mitochondrial signaling pathway and downregulate autophagy by modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Oncology
Shucheng Chen, Lan Yao
Summary: The combination of 3-MA and apatinib effectively inhibits the growth and migration of uterine sarcoma cells, increases apoptosis, and reduces tumor size in xenograft model. Autophagy inhibition may enhance the antitumor effect of apatinib through the PI3K/Akt/mTOR pathway.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Food Science & Technology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Soo-Hyun Jung, Bum Seok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: The study demonstrates that oleanolic acid (OA) can inhibit cell viability, induce apoptosis and autophagy, thereby interfering with the proliferation and development of gastric cancer cells, reducing the phosphorylation levels of the PI3K/AKT/mTOR signaling pathway, exhibiting anti-cancer effects, and showing tumor-reducing effects in a mouse model.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Medicinal
Linlin Wang, Li Cheng, Li Ma, Ammad Ahmad Farooqi, Gan Qiao, Yuxi Zhang, Hanlin Ye, Minghua Liu, Jianlin Huang, Xiaohui Yang, Xiukun Lin, Shousong Cao
Summary: Alnustone exhibits potent growth inhibition against hepatocellular carcinoma (HCC) by inducing apoptosis and inhibiting the PI3K/Akt/mTOR/p70S6K pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Orthopedics
Yang Zhang, Wenguang Liu, Zhonghao Liu, Yi Liu
Summary: In this study, it was found that DAS can inhibit H2O2-induced chondrocyte autophagy and protect chondrocytes from apoptosis and matrix degradation through the PI3K/AKT/mTOR signaling pathway, suggesting a potential therapeutic strategy for osteoarthritis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)