Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

Published 2018 View Full Article

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Title
Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development
Authors
Keywords
ribonuclease H2, RNase H2, genome integrity, innate immunity, embedded ribonucleotides, p53 damage response, DNA damage, mouse development, Aicardi-Goutières syndrome, AGS
Journal
Cell Reports
Volume 25, Issue 5, Pages 1135-1145.e5
Publisher
Elsevier BV
Online
2018-10-30
DOI
10.1016/j.celrep.2018.10.019

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