Large-scale in-silico statistical mutagenesis analysis sheds light on the deleteriousness landscape of the human proteome
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Title
Large-scale in-silico statistical mutagenesis analysis sheds light on the deleteriousness landscape of the human proteome
Authors
Keywords
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Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-11-13
DOI
10.1038/s41598-018-34959-7
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- (2016) György Abrusán et al. PLoS Computational Biology
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- (2015) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
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- (2015) C. Dong et al. HUMAN MOLECULAR GENETICS
- A Proteome-Scale Map of the Human Interactome Network
- (2014) Thomas Rolland et al. CELL
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- (2014) S. Walter Englander et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) P. B. Iynedjian CELLULAR AND MOLECULAR LIFE SCIENCES
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