Article
Pharmacology & Pharmacy
Barbara Gyuricza, Judit P. Szabo, Viktoria Arato, Daniel Szucs, Adrienn Vagner, Dezso Szikra, Aniko Fekete
Summary: A novel radiotracer for cancer diagnosis containing lactosamine was successfully synthesized, showing high affinity and stability. The compound was labeled with a Ga-68 isotope with high radiochemical purity. This radiopharmaceutical has potential applications in tumor imaging in the future.
Article
Engineering, Environmental
Zhen Bao, Jian-Wen Luo, Yu-Sin Wang, Ting-Chou Hu, Sung-Yu Tsai, Yi-Ting Tsai, Huang-Chia Wang, Fu-Hsin Chen, Yu-Chun Lee, Tzong-Liang Tsai, Ren-Jei Chung, Ru-Shi Liu
Summary: In this study, CsPbBr3/Cs4PbBr6 complex nanocrystals were successfully synthesized using a microfluidic system, with a high photoluminescent quantum yield of up to 86.9%. A luminescent ink for inkjet printing was produced, leading to the fabrication of mini-sized color-converted LEDs. This material shows potential for applications in color-converted mini- or micro-LED arrays.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Garry Dolton, Cristina Rius, Aaron Wall, Barbara Szomolay, Valentina Bianchi, Sarah A. E. Galloway, Md Samiul Hasan, Theo Morin, Marine E. Caillaud, Hannah L. Thomas, Sarah Theaker, Li Rong Tan, Anna Fuller, Katie Topley, Mateusz Legut, Meriem Attaf, Jade R. Hopkins, Enas Behiry, Joanna Zabkiewicz, Caroline Alvares, Angharad Lloyd, Amber Rogers, Peter Henley, Christopher Fegan, Oliver Ottmann, Stephen Man, Michael D. Crowther, Marco Donia, Inge Marie Svane, David K. Cole, Paul E. Brown, Pierre Rizkallah, Andrew K. Sewell
Summary: Tumor-infiltrating lymphocyte therapy can activate T cells of the immune system to target and eliminate solid cancers. Through the use of combinatorial peptide libraries and a proteomic database, the antigen specificities of persistent cancer-specific T cell receptors (TCRs) were identified after successful therapy for stage IV malignant melanoma. These TCRs were capable of targeting multiple tumor types through specific epitopes, and the atomic structures revealed the importance of a shared recognition motif. The ability of these multi-epitope targeting T cells to recognize cancer cells surpasses the recognition of individual epitopes, making them promising candidates for future immunotherapies.
Article
Biochemistry & Molecular Biology
Patrick Weber, Michael Dzuricky, Junseon Min, Irene Jenkins, Ashutosh Chilkoti
Summary: Valency is essential for controlling macromolecular interactions and targeting specific cell types. By using core-crosslinkable micelles, researchers have overcome the issue of critical micelle concentration (CMC)-dependent disassembly, maintaining the targeting ability of nanoparticles in solid tumors.
Review
Cell Biology
Cecilia Bergonzini, Kim Kroese, Annelien J. M. Zweemer, Erik H. J. Danen
Summary: Integrins play a crucial role in mediating adhesive interactions between cells and their environment, and their dysregulation is closely associated with cancer progression. Despite promising preclinical results, targeting integrin adhesion complexes in clinical trials for cancer therapy has not met expectations so far, possibly due to variable integrin expression, redundancy in integrin function, distinct roles at different disease stages, and sequestering by tumor-derived extracellular vesicles. However, improving therapeutic delivery at the tumor site through integrin binding ligands is emerging as a successful approach in enhancing the efficacy and safety of conventional therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Joule E. Esene, Mawla Boaks, Anna Bickham, Gregory P. Nordin, Adam T. Woolley
Summary: A 3D printed microfluidic system for microchip electrophoresis (mu CE) of preterm birth (PTB)-related peptides and proteins has been developed. The system allowed for control of fluid flow in device microchannels during sample injection, resulting in optimized separation efficiency and resolution. This system holds promise for PTB risk assessment.
Article
Cell Biology
Lina M. Gallego-Paez, William J. S. Edwards, Manasa Chanduri, Yanyu Guo, Thijs Koorman, Chieh-Yu Lee, Nina Grexa, Patrick Derksen, Jie Yan, Martin A. Schwartz, Jan Mauer, Benjamin Thomas Goult
Summary: This study identified a previously unannotated cassette exon, referred to as exon 17b, in the TLN1 gene. The presence of this exon alters the function of the TLN1 protein in the mechanosensitive adapter system and affects cell adhesion dynamics and motility. This novel exon is detectable in multiple healthy tissues and significantly enriched in certain cancer subtypes.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Applied
Suresh Sulekha Dhanisha, Sudarsanan Drishya, Chandrasekharan Guruvayoorappan
Summary: In this study, macrophage membrane-coated liposome-based biomimetic nanoparticles were developed to improve the in vivo bioavailability of Naringenin (NG). The nanoparticles exhibited good biocompatibility, stability, and pH-responsive drug release kinetics, leading to higher cellular uptake in vitro. The anti-metastatic efficacy of NG-loaded biomimetic nanoparticles was confirmed in experimental models, indicating its potential for reducing metastatic colonies in the lungs.
Article
Pharmacology & Pharmacy
Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu, Xiaofeng Dong
Summary: T7 peptide inhibits endothelial cell proliferation, migration, and tube formation, and promotes apoptosis under different oxygen conditions via integrin α3β1 and αvβ3 pathways. The combination of T7 peptide and meloxicam enhances the anti-tumor effect against HCC tumors.
Article
Oncology
Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Summary: This study presents a new ligand-mimetic beta 3 integrin antagonist that exhibits high activity against alpha v beta 3 and moderate affinity for alpha IIb beta 3, suggesting a new approach to integrin targeting in cancer.
Review
Pharmacology & Pharmacy
Amelia Meecham, John Marshall
Summary: Alpha v beta 6 is a promising therapeutic target due to its limited expression in healthy tissue and significant overexpression in cancer and fibrosis. The peptide A20FMDV2, derived from the foot and mouth disease virus, is highly selective for alpha v beta 6 and can be used therapeutically to target alpha v beta 6 expressing cells. Various strategies have been employed to utilize A20FMDV2 as a molecular-specific drug delivery system, including creating A20FMDV2-drug conjugates and genetically modifying oncolytic viruses to express A20FMDV2.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Engineering, Biomedical
Bin Jiang, Alisa White, Wenquan Ou, Sarah Van Belleghem, Samantha Stewart, James G. Shamul, Shaik O. Rahaman, John P. Fisher, Xiaoming He
Summary: The conventional approach for fabricating PDMS microfluidic devices is inconvenient and requires specialized facilities. This study discovered that reducing the curing agent for crosslinking the PDMS prepolymer increases the noncovalent binding energy of the PDMS surfaces, allowing for the convenient fabrication of leak-free microfluidic devices without the need for plasma or other treatments. This method enables easy loading and retrieval of cells and is faster and more convenient than the conventional covalent bonding method.
BIOACTIVE MATERIALS
(2022)
Review
Oncology
Khurshid Ahmad, Eun Ju Lee, Sibhghatulla Shaikh, Anuj Kumar, Kummara Madhusudana Rao, So-Yong Park, Jun O. Jin, Sung Soo Han, Inho Choi
Summary: Integrins play key roles in cancer progression by regulating critical biological functions and their expressions are frequently altered. Nanotechnology-based approaches have shown to be more precise, safer, and highly effective therapeutic tools compared to conventional therapies, but still face challenges such as inadequate knowledge of nano-bio interactions and the complexities of clinical trials.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yaqun Jiang, Yu Long, Hao Ji, Pengxin Qiao, Qingyao Liu, Xiaotian Xia, Chunxia Qin, Yongxue Zhang, Xiaoli Lan, Yongkang Gai
Summary: In this study, a heterodimeric tracer targeting both CXCR4 and integrin alpha(v)beta(3) was developed for PET imaging of pancreatic cancer, showing promising results in tumor detection and targeting efficiency.
Article
Chemistry, Multidisciplinary
Yipu Du, Julius Reitemeier, Qiang Jiang, Md Omarsany Bappy, Paul W. Bohn, Yanliang Zhang
Summary: A multi-materials multi-scale hybrid printing method is introduced for the rapid fabrication of complex microfluidic devices. A fully printed, assembly-free biosensor for amperometric lactate detection in sweat is demonstrated, featuring sub-100 μm fluidic channels and functionalized electrodes. The sensor exhibits a sensitive response, and the technique opens up new possibilities for point-of-care health monitoring.
Article
Oncology
Wen Tan, Zhangfeng Zhong, Randy P. Carney, Yongfan Men, Jiannan Li, Tingrui Pan, Yitao Wang
SEMINARS IN CANCER BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Yu Wang, Wenyi Li, Meng Li, Siwei Zhao, Fabio De Ferrari, Marco Liscidini, Fiorenzo G. Omenetto
ADVANCED MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Zhaoqing Cong, Lu Zhang, Si-Qi Ma, Kit S. Lam, Fei-Fei Yang, Yong-Hong Liao
Review
Biochemistry & Molecular Biology
Siwei Zhao, Abijeet Singh Mehta, Min Zhao
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Biochemical Research Methods
Sun Yang, Wang Gang, Jing Zhi, Liang Jingting, Sui Jiajie, Fan Jinzhen, Li Jiannan
Article
Chemistry, Multidisciplinary
Fan Zhao, Shan Fan, Deepta Ghate, Svetlana Romanova, Tatiana K. Broniche, Siwei Zhao
Summary: This study introduces an iontophoresis device based on a hydrogel ionic circuit (HIC) for high-efficiency intraocular macromolecule and nanoparticle delivery, allowing safe application of high current intensities with minimal ocular cell death and tissue damage. The device significantly enhances drug delivery compared to conventional iontophoresis, delivering therapeutic doses of drugs within a clinically relevant time frame.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Christopher M. Baehr, Lu Zhang, Yi Wu, Andras Domokos, Wenwu Xiao, Lei Wang, Kit S. Lam
Summary: A transformable peptide nanomaterial has been developed to induce lysosomal membrane permeabilization in non-small cell lung cancer cells, exhibiting cytotoxicity and enhancing cisplatin sensitivity, with promising antitumor effects in mouse xenograft models.
Review
Multidisciplinary Sciences
Jiannan Li, Carolyn Kim, Chi-Chun Pan, Aaron Babian, Elaine Lui, Jeffrey L. Young, Seyedsina Moeinzadeh, Sungwoo Kim, Yunzhi Peter Yang
Summary: This review presents bioprinting methods, biomaterials, and printing strategies for composite tissue constructs for musculoskeletal applications, with a focus on the new strategy of integrating different components through hybrid bioprinting.
Article
Chemistry, Medicinal
Shivani Bansal, Kiem Vu, Ruiwu Liu, Yousif Ajena, Wenwu Xiao, Suvidha M. Menon, Amelia Bennett, Angie Gelli, Kit S. Lam
Summary: This work describes the discovery of bead-bound fungal giant unilamellar vesicles (GUVs) over mammalian GUVs, and the optimization of a peptide, K-oLBF127, with higher antifungal activity, lower hemolytic activity, and cytotoxicity. Animal experiments showed that K-oLBF127 has the potential to effectively reduce fungal burden in vivo.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Yi-Jing Li, Lingze Zhang, Pei-Pei Yang, Kuo Zhang, Xue-Feng Gong, Da-Yong Hou, Hui Cao, Xiao-Chun Wu, Ruiwu Liu, Kit S. Lam, Lei Wang
Summary: In this study, anti-adhesion peptides (AAPs) were screened using a combinatorial peptide library method, and these peptides were then coated on gold nanorods to enhance their circulation half-life and alter their biodistribution profile in mice. The bioinspired screening strategy and resulting peptides show great potential for enhancing the delivery efficiency and targeting ability of nanomaterials.
Article
Chemistry, Multidisciplinary
Fan Zhao, Yajuan Su, Junying Wang, Svetlana Romanova, Dominick J. DiMaio, Jingwei Xie, Siwei Zhao
Summary: Biofilm infection in chronic wounds is common and delays wound healing. This paper describes a highly effective electrical antibiofilm treatment system that uses high-intensity current to debride biofilm and enhance antibiotic delivery. The system reduces bacterial count of MRSA biofilm-infected ex vivo skin wounds and demonstrates in vivo antibiofilm efficacy in a diabetic mouse-based wound infection model. This novel technology provides a quick, safe, and highly efficacious treatment for chronic wound biofilm infections.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Xingjian Yu, Ming Ruan, Yongheng Wang, Audrey Nguyen, Wenwu Xiao, Yousif Ajena, Lucas N. Solano, Ruiwu Liu, Kit S. Lam
Summary: Human serum albumin (HSA) is an important protein involved in the transportation of drugs, metabolites, nutrients, and small molecules. Researchers have discovered site-specific bioconjugation strategies for HSA that can significantly expand its role in theranostics. By screening peptide libraries, specific and covalent binding elements to HSA have been identified, along with the conjugation sites. These promising strategies have potential applications in biomedicine.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Engineering, Biomedical
Jiannan Li, Seyedsina Moeinzadeh, Carolyn Kim, Chi -Chun Pan, George Weale, Sungwoo Kim, Geoffrey Abrams, Aaron W. James, HyeRan Choo, Charles Chan, Yunzhi Peter Yang
Summary: This paper presents the development of a room temperature printable hydrogel bioink by introducing PEGDMA and xanthan gum into the GelMA/alginate system. The newly developed hydrogel system demonstrates extrusion printability, tunable mechanical property and degradation, ionic solubility, and cytocompatibility.
Article
Chemistry, Multidisciplinary
Xingjian Yu, Bofeng Pan, Cunyi Zhao, Diedra Shorty, Lucas N. N. Solano, Gang Sun, Ruiwu Liu, Kit S. S. Lam
Summary: Effective control of the COVID-19 pandemic requires reliable and flexible in-home personal use diagnostics for the detection of viral antigens. This study successfully discovered peptidic ligands with high binding affinity to the SARS-CoV-2 spike protein, allowing for the development of personal use sensors with low nanomolar sensitivity. These sensors show comparable detection sensitivity to current FDA-approved home detection kits and can detect both the original strain and the Delta variant of the S-protein.
