High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target

(2018) Kingsley Ibhazehiebo et al.   BRAIN

Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

(2018) Peter M. Eimon et al.   Nature Communications

A generative vision model that trains with high data efficiency and breaks text-based CAPTCHAs

(2017) Dileep George et al.   SCIENCE

Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish

(2016) Xudong Lin et al.   Biomicrofluidics

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

(2016) Giancarlo Bruni et al.   Nature Chemical Biology

High-throughput mapping of brain-wide activity in awake and drug-responsive vertebrates

(2015) Xudong Lin et al.   LAB ON A CHIP

Deep learning

(2015) Yann LeCun et al.   NATURE

Whole-brain activity mapping onto a zebrafish brain atlas

(2015) Owen Randlett et al.   NATURE METHODS

AMPA receptors as a molecular target in epilepsy therapy

(2013) M. A. Rogawski   ACTA NEUROLOGICA SCANDINAVICA

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

(2013) Misha B Ahrens et al.   NATURE METHODS

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Further evidence for the sleep-promoting effects of 5-HT2A receptor antagonists and demonstration of synergistic effects with the hypnotic, zolpidem in rats

(2013) Guy Griebel et al.   NEUROPHARMACOLOGY

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

(2013) Tatiana Afrikanova et al.   PLoS One

Histone deacetylase 10 promotes autophagy-mediated cell survival

(2013) I. Oehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The first mecp2-null zebrafish model shows altered motor behaviors

(2013) Thomas Pietri et al.   Frontiers in Neural Circuits

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

Brain-wide neuronal dynamics during motor adaptation in zebrafish

(2012) Misha B. Ahrens et al.   NATURE

Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand

(2012) Alessia Ligresti et al.   PHARMACOLOGICAL RESEARCH

Technologies for Micromanipulating, Imaging, and Phenotyping Small Invertebrates and Vertebrates

(2011) Mehmet Fatih Yanik et al.   Annual Review of Biomedical Engineering

Neurologic and ocular phenotype in Pitt–Hopkins syndrome and a zebrafish model

(2011) Antje Brockschmidt et al.   HUMAN GENETICS

Selective GABA Transporter Inhibitors Tiagabine and EF1502 Exhibit Mechanistic Differences in Their Ability to Modulate the Ataxia and Anticonvulsant Action of the Extrasynaptic GABAA Receptor Agonist Gaboxadol

(2011) K. K. Madsen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Deep and fast live imaging with two-photon scanned light-sheet microscopy

(2011) Thai V Truong et al.   NATURE METHODS

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

(2010) David Kokel et al.   Nature Chemical Biology

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466

(2009) Brita Fritsch et al.   EPILEPSIA

On the mechanism of antidepressant-like action of berberine chloride

(2008) Shrinivas K. Kulkarni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY