Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

The Expanding Landscape of Alternative Splicing Variation in Human Populations

(2018) Eddie Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity

(2018) Joshua A Hayward et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

(2018) Nadine M. Shaban et al.   MOLECULAR CELL

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

(2018) Terumasa Ikeda et al.   PLoS Pathogens

Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3

(2017) Rokusuke Yoshikawa et al.   JOURNAL OF VIROLOGY

Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function

(2017) Violeta Rayon-Estrada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans

(2017) Zeli Zhang et al.   PLoS Pathogens

HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

(2017) Yusuke Nakano et al.   PLoS Pathogens

Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G

(2017) Darja Pollpeter et al.   Nature Microbiology

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases

(2016) Sachini U. Siriwardena et al.   CHEMICAL REVIEWS

Biochemical Characterization of APOBEC3H Variants: Implications for Their HIV-1 Restriction Activity and mC Modification

(2016) Jiang Gu et al.   JOURNAL OF MOLECULAR BIOLOGY

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

(2015) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

(2015) Viviana Simon et al.   NATURE IMMUNOLOGY

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

Extremely High Mutation Rate of HIV-1 In Vivo

(2015) José M. Cuevas et al.   PLOS BIOLOGY

Insights into the Motif Preference of APOBEC3 Enzymes

(2014) Diako Ebrahimi et al.   PLoS One

Identification of genetic variants associated with alternative splicing using sQTLseekeR

(2014) Jean Monlong et al.   Nature Communications

Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

(2014) Eric W. Refsland et al.   PLoS Genetics

Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

(2014) Eun-Young Kim et al.   PLoS Pathogens

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

HIV-1 Vif Adaptation to Human APOBEC3H Haplotypes

(2013) Marcel Ooms et al.   Cell Host & Microbe

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

Host gene evolution traces the evolutionary history of ancient primate lentiviruses

(2013) A. A. Compton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Great Apes and Zoonoses

(2013) P. M. Sharp et al.   SCIENCE

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Reduced APOBEC3H Variant Anti-Viral Activities Are Associated with Altered RNA Binding Activities

(2012) Anjie Zhen et al.   PLoS One

Alternative Splicing of RNA Triplets Is Often Regulated and Accelerates Proteome Evolution

(2012) Robert K. Bradley et al.   PLOS BIOLOGY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 Activity

(2011) X. Wang et al.   JOURNAL OF VIROLOGY

Two-stepping through time: mammals and viruses

(2011) Nicholas R. Meyerson et al.   TRENDS IN MICROBIOLOGY

RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression

(2010) E. Lalonde et al.   GENOME RESEARCH

Human APOBEC3G-Mediated Editing Can Promote HIV-1 Sequence Diversification and Accelerate Adaptation to Selective Pressure

(2010) E.-Y. Kim et al.   JOURNAL OF VIROLOGY

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function

(2010) J. S. Albin et al.   JOURNAL OF VIROLOGY

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2

(2010) C. Celum et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent

(2009) Edward P. Browne et al.   VIROLOGY

Likely Role of APOBEC3G-Mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance

(2009) Patric Jern et al.   PLoS Pathogens

HIVcleave: a web-server for predicting human immunodeficiency virus protease cleavage sites in proteins

(2008) Hong-Bin Shen et al.   ANALYTICAL BIOCHEMISTRY

Antiretroelement Activity of APOBEC3H Was Lost Twice in Recent Human Evolution

(2008) Molly OhAinle et al.   Cell Host & Microbe

Evolution of HIV-1 Isolates that Use a Novel Vif-Independent Mechanism to Resist Restriction by Human APOBEC3G

(2008) Guylaine Haché et al.   CURRENT BIOLOGY

Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1

(2008) Lindi Tan et al.   FASEB JOURNAL

Polymorphisms and Splice Variants Influence the Antiretroviral Activity of Human APOBEC3H

(2008) A. Harari et al.   JOURNAL OF VIROLOGY

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins

(2008) R. S. LaRue et al.   JOURNAL OF VIROLOGY

The DNA Deaminase Activity of Human APOBEC3G Is Required for Ty1, MusD, and Human Immunodeficiency Virus Type 1 Restriction

(2008) A. J. Schumacher et al.   JOURNAL OF VIROLOGY

Cytidine deamination induced HIV-1 drug resistance

(2008) L. C. F. Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The AID/APOBEC family of nucleic acid mutators

(2008) Silvestro G Conticello   GENOME BIOLOGY