CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

(2018) Vivek Iyer et al.   PLoS Genetics

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein

(2017) Lichun Tang et al.   MOLECULAR GENETICS AND GENOMICS

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

(2017) Elizabeth Anne Hay et al.   NEUROPEPTIDES

Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53

(2017) Neeraj K. Aryal et al.   Oncotarget

Off-target mutations are rare in Cas9-modified mice

(2015) Vivek Iyer et al.   NATURE METHODS

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

(2014) Bin Shen et al.   NATURE METHODS

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY