An Integrated Cytoskeletal Model of Neurite Outgrowth

Mammalian nonmuscle myosin II comes in three flavors

(2018) Maria S. Shutova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microtubule Polymerization and Cross-Link Dynamics Explain Axonal Stiffness and Damage

(2018) Rijk de Rooij et al.   BIOPHYSICAL JOURNAL

Cytoskeletal mechanisms of axonal contractility

(2018) Sampada P. Mutalik et al.   BIOPHYSICAL JOURNAL

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Cytoskeleton dynamics in axon regeneration

(2018) Oriane Blanquie et al.   CURRENT OPINION IN NEUROBIOLOGY

Understanding axon guidance: are we nearly there yet?

(2018) Esther T. Stoeckli   DEVELOPMENT

The functional architecture of axonal actin

(2018) Marie-Jeanne Papandréou et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment

(2018) Stephen L. Berger et al.   NEURON

Polarity Sorting of Microtubules in the Axon

(2018) Anand N. Rao et al.   TRENDS IN NEUROSCIENCES

Non-invasive Neurite Mechanics in Differentiated PC12 Cells

(2018) Fernanda Gárate et al.   Frontiers in Cellular Neuroscience

Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation

(2018) Rijk de Rooij et al.   BIOPHYSICAL JOURNAL

The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones

(2017) Sayantanee Biswas et al.   JOURNAL OF NEUROSCIENCE

Actin-based growth cone motility and guidance

(2017) Omotola F. Omotade et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation

(2017) Kenneth B. Buck et al.   MOLECULAR BIOLOGY OF THE CELL

Polarity sorting of axonal microtubules: a computational study

(2017) Erin M. Craig et al.   MOLECULAR BIOLOGY OF THE CELL

The nano-architecture of the axonal cytoskeleton

(2017) Christophe Leterrier et al.   NATURE REVIEWS NEUROSCIENCE

Transition from turbulent to coherent flows in confined three-dimensional active fluids

(2017) Kun-Ta Wu et al.   SCIENCE

Moonlighting Motors: Kinesin, Dynein, and Cell Polarity

(2017) Wen Lu et al.   TRENDS IN CELL BIOLOGY

Discovery of long-range inhibitory signaling to ensure single axon formation

(2017) Tetsuya Takano et al.   Nature Communications

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

(2017) Anand N. Rao et al.   Cell Reports

Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex

(2017) William M. McFadden et al.   PLoS Computational Biology

Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

(2017) Michael Krieg et al.   eLife

Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis

(2017) Yan Wang et al.   Frontiers in Molecular Neuroscience

Neurite elongation is highly correlated with bulk forward translocation of microtubules

(2017) Ahmad I. M. Athamneh et al.   Scientific Reports

Coupled circumferential and axial tension driven by actin and myosin influences in vivo axon diameter

(2017) Anthony Fan et al.   Scientific Reports

Mechanism of Axonal Contractility in Embryonic Drosophila Motor Neurons In Vivo

(2016) Alireza Tofangchi et al.   BIOPHYSICAL JOURNAL

A conceptual view at microtubule plus end dynamics in neuronal axons

(2016) André Voelzmann et al.   BRAIN RESEARCH BULLETIN

Microtubules in health and degenerative disease of the nervous system

(2016) Andrew J. Matamoros et al.   BRAIN RESEARCH BULLETIN

Modeling molecular mechanisms in the axon

(2016) R. de Rooij et al.   COMPUTATIONAL MECHANICS

Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance

(2016) Garrett M. Cammarata et al.   Cytoskeleton

Waves, rings, and trails: The scenic landscape of axonal actin

(2016) Subhojit Roy   JOURNAL OF CELL BIOLOGY

Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions

(2016) R. H. Nichol et al.   JOURNAL OF NEUROSCIENCE

Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation

(2016) K. W. Yau et al.   JOURNAL OF NEUROSCIENCE

Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance

(2016) Stephen G. Turney et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule Organization Determines Axonal Transport Dynamics

(2016) Shaul Yogev et al.   NEURON

Role of kinesin-1–based microtubule sliding inDrosophilanervous system development

(2016) Michael Winding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubules and Growth Cones: Motors Drive the Turn

(2016) Olga I. Kahn et al.   TRENDS IN NEUROSCIENCES

The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter

(2016) Sérgio Carvalho Leite et al.   Cell Reports

Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate

(2016) Yuan Ren et al.   NEURAL PLASTICITY

Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity

(2016) Steven L. Jones et al.   NEURAL PLASTICITY

Substrate Deformation Predicts Neuronal Growth Cone Advance

(2015) Ahmad I.M. Athamneh et al.   BIOPHYSICAL JOURNAL

Measurement of Subcellular Force Generation in Neurons

(2015) Matthew O’Toole et al.   BIOPHYSICAL JOURNAL

Pavarotti/MKLP1 Regulates Microtubule Sliding and Neurite Outgrowth in Drosophila Neurons

(2015) Urko del Castillo et al.   CURRENT BIOLOGY

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

Shootin1–cortactin interaction mediates signal–force transduction for axon outgrowth

(2015) Yusuke Kubo et al.   JOURNAL OF CELL BIOLOGY

A dynamic formin-dependent deep F-actin network in axons

(2015) Archan Ganguly et al.   JOURNAL OF CELL BIOLOGY

Neuronal polarity: an evolutionary perspective

(2015) M. M. Rolls et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Membrane tension and cytoskeleton organization in cell motility

(2015) Pierre Sens et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Active gel physics

(2015) J. Prost et al.   Nature Physics

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

(2015) Sam F.B. van Beuningen et al.   NEURON

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

Turning Bacteria Suspensions into Superfluids

(2015) Héctor Matías López et al.   PHYSICAL REVIEW LETTERS

Developmental axon stretch stimulates neuron growth while maintaining normal electrical activity, intracellular calcium flux, and somatic morphology

(2015) Joseph R. Loverde et al.   Frontiers in Cellular Neuroscience

Tension-driven axon assembly: a possible mechanism

(2015) Steven R. Heidemann et al.   Frontiers in Cellular Neuroscience

Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth

(2015) Maximilian Jakobs et al.   Frontiers in Cellular Neuroscience

Quantifying mechanical force in axonal growth and guidance

(2015) Ahmad I. M. Athamneh et al.   Frontiers in Cellular Neuroscience

Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury

(2015) Thomas Grevesse et al.   Scientific Reports

STED Nanoscopy Reveals the Ubiquity of Subcortical Cytoskeleton Periodicity in Living Neurons

(2015) Elisa D’Este et al.   Cell Reports

Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

(2015) Urko del Castillo et al.   eLife

Myelin-associated inhibitors in axonal growth after CNS injury

(2014) Cédric G Geoffroy et al.   CURRENT OPINION IN NEUROBIOLOGY

Cytoplasmic dynein pushes the cytoskeletal meshwork forward during axonal elongation

(2014) D. H. Roossien et al.   JOURNAL OF CELL SCIENCE

The role of mechanics during brain development

(2014) Silvia Budday et al.   JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS

Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

(2014) Christian Duellberg et al.   NATURE CELL BIOLOGY

Mechanical control of the sense of touch by β-spectrin

(2014) Michael Krieg et al.   NATURE CELL BIOLOGY

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Flocking at a distance in active granular matter

(2014) Nitin Kumar et al.   Nature Communications

Dynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons

(2014) Callen Hyland et al.   Scientific Reports

Low Piconewton Towing of CNS Axons against Diffusing and Surface-Bound Repellents Requires the Inhibition of Motor Protein-Associated Pathways

(2014) Devrim Kilinc et al.   Scientific Reports

Developmental mechanism of the periodic membrane skeleton in axons

(2014) Guisheng Zhong et al.   eLife

Mechanics in Neuronal Development and Repair

(2013) Kristian Franze et al.   Annual Review of Biomedical Engineering

Biomechanical imaging of cell stiffness and prestress with subcellular resolution

(2013) Elizabeth P. Canović et al.   Biomechanics and Modeling in Mechanobiology

Initial Neurite Outgrowth in Drosophila Neurons Is Driven by Kinesin-Powered Microtubule Sliding

(2013) Wen Lu et al.   CURRENT BIOLOGY

Conversion of a Signal into Forces for Axon Outgrowth through Pak1-Mediated Shootin1 Phosphorylation

(2013) Michinori Toriyama et al.   CURRENT BIOLOGY

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility

(2013) Chi Wai Lee et al.   CURRENT BIOLOGY

Neuron Biomechanics Probed by Atomic Force Microscopy

(2013) Elise Spedden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of Three Full-length Human Nonmuscle Myosin II Paralogs

(2013) Neil Billington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin dynamics in growth cone motility and navigation

(2013) Timothy M. Gomez et al.   JOURNAL OF NEUROCHEMISTRY

Forces from the rear: deformed microtubules in neuronal growth cones influence retrograde flow and advancement

(2013) Philipp Rauch et al.   NEW JOURNAL OF PHYSICS

Comparison of the Force Exerted by Hippocampal and DRG Growth Cones

(2013) Ladan Amin et al.   PLoS One

Drosophila Growth Cones Advance by Forward Translocation of the Neuronal Cytoskeletal Meshwork In Vivo

(2013) Douglas H. Roossien et al.   PLoS One

Hydrodynamics of soft active matter

(2013) M. C. Marchetti et al.   REVIEWS OF MODERN PHYSICS

Myosin motors fragment and compact membrane-bound actin filaments

(2013) Sven K Vogel et al.   eLife

The Role of Membrane Stiffness and Actin Turnover on the Force Exerted by DRG Lamellipodia

(2012) Ladan Amin et al.   BIOPHYSICAL JOURNAL

Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons

(2012) Daniel Koch et al.   BIOPHYSICAL JOURNAL

Membrane Tension, Myosin Force, and Actin Turnover Maintain Actin Treadmill in the Nerve Growth Cone

(2012) Erin M. Craig et al.   BIOPHYSICAL JOURNAL

Mitotic Motors Coregulate Microtubule Patterns in Axons and Dendrites

(2012) S. Lin et al.   JOURNAL OF NEUROSCIENCE

Spectraplakins Promote Microtubule-Mediated Axonal Growth by Functioning As Structural Microtubule-Associated Proteins and EB1-Dependent +TIPs (Tip Interacting Proteins)

(2012) J. Alves-Silva et al.   JOURNAL OF NEUROSCIENCE

The dendritic tree and brain disorders

(2012) Vaishali A. Kulkarni et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT–dependent neurite outgrowth in Aplysia bag cell neurons

(2012) Xiao-Feng Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Development of dendrite polarity in Drosophila neurons

(2012) Sarah E Hill et al.   Neural Development

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

(2012) Kevin C. Flynn et al.   NEURON

The Role of Actin Turnover in Retrograde Actin Network Flow in Neuronal Growth Cones

(2012) David Van Goor et al.   PLoS One

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

The Role of Stretching in Slow Axonal Transport

(2011) Matthew O'Toole et al.   BIOPHYSICAL JOURNAL

MEMS sensors and microsystems for cell mechanobiology

(2011) Jagannathan Rajagopalan et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting

(2011) Tapan A Maniar et al.   NATURE NEUROSCIENCE

Hydrodynamics of active permeating gels

(2011) A C Callan-Jones et al.   NEW JOURNAL OF PHYSICS

Growth cones as soft and weak force generators

(2011) T. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules

(2011) E.-M. Hur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of forces in axonal elongation

(2011) Daniel M. Suter et al.   PROGRESS IN NEUROBIOLOGY

Mechanical Manipulation of Neurons to Control Axonal Development

(2011) Phillip Lamoureux et al.   Jove-Journal of Visualized Experiments

Mapping the cytoskeletal prestress

(2010) Chan Young Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Drag Force as a Tool to Test the Active Mechanical Response of PC12 Neurites

(2010) Roberto Bernal et al.   BIOPHYSICAL JOURNAL

Force Generation in Lamellipodia Is a Probabilistic Process with Fast Growth and Retraction Events

(2010) Rajesh Shahapure et al.   BIOPHYSICAL JOURNAL

History-Dependent Catastrophes Regulate Axonal Microtubule Behavior

(2010) Tatiana Stepanova et al.   CURRENT BIOLOGY

Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1

(2010) Bonnie M. Marsick et al.   Developmental Neurobiology

Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II

(2010) Ailish Murray et al.   Neural Development

Topography and Nanomechanics of Live Neuronal Growth Cones Analyzed by Atomic Force Microscopy

(2009) Ying Xiong et al.   BIOPHYSICAL JOURNAL

Growth and elongation within and along the axon

(2009) Phillip Lamoureux et al.   Developmental Neurobiology

Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

(2009) Min D. Tang-Schomer et al.   FASEB JOURNAL

Force amplification response of actin filaments under confined compression

(2009) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Buckling, stiffening, and negative dissipation in the dynamics of a biopolymer in an active medium

(2009) N. Kikuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminals

(2009) S. Siechen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretch growth of integrated axon tracts: Extremes and exploitations

(2009) Douglas H. Smith   PROGRESS IN NEUROBIOLOGY

A Physical Model of Axonal Elongation: Force, Viscosity, and Adhesions Govern the Mode of Outgrowth

(2008) Matthew O’Toole et al.   BIOPHYSICAL JOURNAL

Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth

(2008) Andrew W. Schaefer et al.   DEVELOPMENTAL CELL

Quantitative analysis of microtubule dynamics during adhesion-mediated growth cone guidance

(2008) Aih Cheun Lee et al.   Developmental Neurobiology

Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth

(2008) Tadayuki Shimada et al.   JOURNAL OF CELL BIOLOGY

Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule

(2008) Takekazu Kubo et al.   JOURNAL OF NEUROCHEMISTRY

A Molecular Clutch between the Actin Flow and N-Cadherin Adhesions Drives Growth Cone Migration

(2008) L. Bard et al.   JOURNAL OF NEUROSCIENCE

Modeling mitochondrial dynamics during in vivo axonal elongation

(2008) Matthew O’Toole et al.   JOURNAL OF THEORETICAL BIOLOGY

Myosin IIC: A Third Molecular Motor Driving Neuronal Dynamics

(2008) Steven R. Wylie et al.   MOLECULAR BIOLOGY OF THE CELL

Arp2/3 Complex Is Important for Filopodia Formation, Growth Cone Motility, and Neuritogenesis in Neuronal Cells

(2008) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Dorsal Root Ganglion Neurons React to Semaphorin 3A Application through a Biphasic Response that Requires Multiple Myosin II Isoforms

(2008) Jacquelyn A. Brown et al.   MOLECULAR BIOLOGY OF THE CELL

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

(2008) Stefan A. Koestler et al.   NATURE CELL BIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE