Brain Derived Neurotrophic Factor (BDNF) Delays Onset of Pathogenesis in Transgenic Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1)

Neurochemical abnormalities in premanifest and early spinocerebellar ataxias

(2018) James M. Joers et al.   ANNALS OF NEUROLOGY

Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1

(2018) Austin Ferro et al.   PLoS One

Astroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner

(2018) Joo Hyun Kim et al.   GLIA

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation

(2018) Bruno Lima Giacobbo et al.   MOLECULAR NEUROBIOLOGY

Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

(2017) Wenhui Qu et al.   Journal of Neuroinflammation

Polyglutamine spinocerebellar ataxias — from genes to potential treatments

(2017) Henry L. Paulson et al.   NATURE REVIEWS NEUROSCIENCE

Motor and Cerebellar Architectural Abnormalities during the Early Progression of Ataxia in a Mouse Model of SCA1 and How Early Prevention Leads to a Better Outcome Later in Life

(2017) Mohamed F. Ibrahim et al.   Frontiers in Cellular Neuroscience

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

(2017) Myeongjeong Choo et al.   Nature Communications

Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?

(2016) David C. Rubinsztein et al.   BIOESSAYS

Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology

(2016) Céline Ruegsegger et al.   NEURON

Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways

(2016) Melissa Ingram et al.   NEURON

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Differences in BDNF Serum Levels in Patients with AlzheimerÂ’s Disease and Mild Cognitive Impairment

(2015) Hyun Woo Shin Hyun Kim   African Journal of Psychiatry

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability

(2015) J. M. Dell'Orco et al.   JOURNAL OF NEUROSCIENCE

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1

(2015) M. Cvetanovic et al.   NEUROSCIENCE

Decreased Expression of Glutamate Transporter GLAST in Bergmann Glia Is Associated with the Loss of Purkinje Neurons in the Spinocerebellar Ataxia Type 1

(2014) Marija Cvetanovic   CEREBELLUM

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias

(2013) A. Matilla-Dueñas et al.   CEREBELLUM

Purkinje Cell Ataxin-1 Modulates Climbing Fiber Synaptic Input in Developing and Adult Mouse Cerebellum

(2013) B. A. Ebner et al.   JOURNAL OF NEUROSCIENCE

Presymptomatic features of spinocerebellar ataxias

(2013) Elsdon Storey   LANCET NEUROLOGY

Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data

(2013) Heike Jacobi et al.   LANCET NEUROLOGY

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

(2013) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Role of BDNF in Central Motor Structures and Motor Diseases

(2013) Yan-Yan He et al.   MOLECULAR NEUROBIOLOGY

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

(2013) Carmela Giampà et al.   PLoS One

Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7

(2013) Udo Rüb et al.   PROGRESS IN NEUROBIOLOGY

Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum

(2012) Makoto Takahashi et al.   NEUROPATHOLOGY

NF-κB Signaling Pathways

(2012) Stefka Mincheva-Tasheva et al.   NEUROSCIENTIST

Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons

(2011) Ying Huang et al.   EXPERIMENTAL NEUROLOGY

Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1

(2011) R. Hourez et al.   JOURNAL OF NEUROSCIENCE

Abnormalities in the Climbing Fiber-Purkinje Cell Circuitry Contribute to Neuronal Dysfunction in ATXN1[82Q] Mice

(2011) J. A. Barnes et al.   JOURNAL OF NEUROSCIENCE

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

(2011) Albert Giralt et al.   Molecular Neurodegeneration

Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1

(2011) Marija Cvetanovic et al.   NATURE MEDICINE

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

SCA1-like Disease in Mice Expressing Wild-Type Ataxin-1 with a Serine to Aspartic Acid Replacement at Residue 776

(2010) Lisa Duvick et al.   NEURON

Differential expression of TrkB isoforms switches climbing fiber-Purkinje cell synaptogenesis to selective synapse elimination

(2009) Rachel M. Sherrard et al.   Developmental Neurobiology

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

BDNF increases homotypic olivocerebellar reinnervation and associated fine motor and cognitive skill

(2008) M. L. Willson et al.   BRAIN

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON