Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis

Metformin-associated Chemopreventive Effects on Recurrence After Hepatic Resection of Hepatocellular Carcinoma: From In Vitro to a Clinical Study

(2018)   ANTICANCER RESEARCH

Annexin A5 overexpression might suppress proliferation and metastasis of human uterine cervical carcinoma cells

(2018) Xin Li et al.   Cancer Biomarkers

C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma

(2018) Ying Zhu et al.   CANCER SCIENCE

Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression

(2018) Xiaopeng Zhu et al.   Lipids in Health and Disease

Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis

(2016) F. Cauchy et al.   CLINICAL SCIENCE

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

(2016) Iris Martinez-Quetglas et al.   GASTROENTEROLOGY

IGF-I receptor as an emerging potential molecular-targeted for hepatocellular carcinoma in vitro and in vivo

(2016) Min Yao et al.   TUMOR BIOLOGY

Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

(2016) Hend Mohamed El Tayebi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

(2016) Mamatha Bhat et al.   Oncotarget

Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy

(2016) Hanmin Li et al.   Oncotarget

Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin

(2016) Qiongzhu Dong et al.   Oncotarget

Metformin Treatment Prevents Sedentariness Related Damages in Mice

(2016) Pamela Senesi et al.   Journal of Diabetes Research

Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

(2015) Jiang Chen et al.   CANCER LETTERS

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma

(2015) T. Kawai et al.   CLINICAL CANCER RESEARCH

AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells

(2015) Qiong Lv et al.   LIFE SCIENCES

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

(2015) Zhiguang Xiao et al.   Oncotarget

Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment

(2015) Javier A. Menendez et al.   Oncotarget

Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-mediated Signaling in the Phenotypes of Hepatocellular Carcinoma Cells

(2015) Ya-Wen Chen et al.   NEOPLASIA

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo

(2014) HISAAKI MIYOSHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression

(2014) XIAOYAN LIANG et al.   Molecular Medicine Reports

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

(2014) Jidong Cheng et al.   PLoS One

Anti-Diabetic Medications and the Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis

(2013) Siddharth Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Metformin Inhibits Growth of Hepatocellular Carcinoma Cells by Inducing Apoptosis Via Mitochondrion-mediated Pathway

(2013) Yu Xiong et al.   Asian Pacific Journal of Cancer Prevention

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

(2013) Olivier Govaere et al.   GUT

Role of Annexin A5 in Cisplatin-induced Toxicity in Renal Cells

(2013) Jin-Joo Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor microenviroment and hepatocellular carcinoma metastasis

(2013) Hongyang Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo

(2013) XIANBIN CAI et al.   ONCOLOGY REPORTS

Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis

(2012) K. Bhalla et al.   Cancer Prevention Research

In vitro and in vivo antitumoral action of metformin on hepatocellular carcinoma

(2012) Zhan Qu et al.   HEPATOLOGY RESEARCH

Oral Insulin Secretagogues, Insulin, and Cancer Risk in Type 2 Diabetes Mellitus

(2012) Chia-Hsuin Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin in cancer: translational challenges

(2012) Ryan J O Dowling et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis

(2012) Hui Zhang et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Inhibition of autocrine IGF-II on effect of human HepG2 cell proliferation and angiogenesis factor expression

(2012) Ninghua Yao et al.   TUMOR BIOLOGY

Risk of Hepatocellular Carcinoma in Diabetic Patients and Risk Reduction Associated With Anti-Diabetic Therapy: A Population-Based Cohort Study

(2011) Shih-Wei Lai et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

(2011) Emily Jane Gallagher et al.   Annals of the New York Academy of Sciences

Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients

(2011) H.M. El Tayebi et al.   BIOMARKERS

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis

(2011) Haeryoung Kim et al.   HEPATOLOGY

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

(2011) Sufen Shang et al.   HEPATOLOGY

Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta-analysis of cohort studies

(2011) Chenggang Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Upregulation of the Insulin Receptor and Type I Insulin-Like Growth Factor Receptor Are Early Events in Hepatocarcinogenesis

(2011) Eiman Aleem et al.   TOXICOLOGIC PATHOLOGY

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Surveillance for Hepatocellular Carcinoma in Patients with Cirrhosis Improves Outcome

(2008) Richard Todd Stravitz et al.   AMERICAN JOURNAL OF MEDICINE

Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis

(2008) Tanja Nussbaum et al.   HEPATOLOGY