Article
Oncology
Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu
Summary: This study investigated the role of DYNLT3 protein in cervical cancer and its molecular mechanisms. The results showed that DYNLT3 inhibited cell proliferation, migration, and invasion in cervical cancer, and promoted apoptosis. It was also found that DYNLT3 suppressed the expression of Wnt signaling pathway and EMT-related proteins. Furthermore, upregulation of DYNLT3 expression inhibited tumor growth and metastasis in vivo.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Lin, Yushan Chen, Rongqiang Shen, Dingzhu Chen, Yimin Lin
Summary: The study found that microRNA-148a-3p regulates the function of esophageal carcinoma cells by targeting CEP55, suppressing malignant behaviors and affecting cell proliferation and migration.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Biotechnology & Applied Microbiology
Yan Gao, Ting Zou, Wentong Liang, Zhijun Zhang, Mingrong Qie
Summary: The study revealed the crucial regulatory role of HAND2-AS1 in cervical cancer, which upregulated TIMP3 expression through competitive binding to miR-21-5p, leading to suppression of cell proliferation, migration, invasion, and promotion of apoptosis. HAND2-AS1 may serve as a potential target for cervical cancer therapy.
CANCER GENE THERAPY
(2021)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medical Laboratory Technology
Jianzhong Wu, Ling Gao, Hong Chen, Xiaojun Zhou, Xialiang Lu, Zhongqi Mao
Summary: This study revealed that in poorly differentiated gastric cancer (PDGC), the upregulation of LINC02535 expression contributes to cell proliferation, migration, invasion, and wound healing, while its inhibition facilitates cell apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Chunmei Sai, Wei Qin, Junyu Meng, Li-Na Gao, Lufen Huang, Zhen Zhang, Huannan Wang, Haixia Chen, Chaohua Yan
Summary: MA, a novel compound isolated from Macleaya cordata and Macleaya microcarpa, demonstrates anticervical cancer activity through regulation of cell cycle, induction of apoptosis, inhibition of Wnt signaling pathway-related protein expression, and suppression of cell migration and invasion in HeLa cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Zhen Shen, Weiguo Song, Lili Qian, Jing Zhu, Yuebo Li, Min Li, Tianjiao Zhang, Weidong Zhao, Ying Zhou, Xingsheng Yang
Summary: Claudin 1 was found to inhibit cell proliferation and migration, and promote apoptosis in different human cervical cancer cell lines. In vivo experiments showed that overexpression of claudin 1 reduced tumor growth. The study suggests that claudin 1 may play an anti-tumor role in cervical squamous cell carcinoma.
Article
Obstetrics & Gynecology
Huier Sun, Xuejun Chen
Summary: This study revealed that miR-106b-5p modulates cervical squamous cell carcinoma cells by targeting TIMP2, promoting malignant behaviors and showing an inverse correlation with TIMP2 levels.
REPRODUCTIVE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Oncology
Shoukai Zhang, Hulai Wei, Xiaoqin Ha, Yueyu Zhang, Yufen Guo
Summary: The overexpression of NK4 gene inhibits cell proliferation and migration, promotes cell apoptosis, and induces cell cycle arrest in S phase in laryngeal carcinoma AMC-HN-8 cells. NK4 overexpression also inhibits the tumorigenic ability of AMC-HN-8 cells, possibly through the regulation of the DKK1/Wnt1/beta-Catenin signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiqun Dai, Xiaolong Sun, Bohan Li, Hui Ma, Pingping Wu, Yingping Zhang, Meilin Zhu, Hong-Mei Li, Minjian Qin, Cheng-Zhu Wu
Summary: Hispidulin, a flavonoid extracted from Salvia plebeia, has shown anti-proliferative, apoptosis-inducing, migration and invasion inhibiting effects in nasopharyngeal carcinoma cells. Experimental results suggest that hispidulin may be a potentially effective agent for NPC treatment.