Article
Allergy
Tomoko Hirano, Tetsuya Honda, Shuto Kanameishi, Yuki Honda, Gyohei Egawa, Akihiko Kitoh, Saeko Nakajima, Atsushi Otsuka, Takashi Nomura, Teruki Dainichi, Tomonori Yaguchi, Takashi Inozume, Tatsuki R. Kataoka, Koji Tamada, Kenji Kabashima
Summary: The PD-1/PD-L1 pathway negatively regulates CD8(+) T cell activation in the skin through mast cells (MCs), which are found to highly express PD-L1 and play a crucial role in modulating inflammatory responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Virology
Wanxiaojie Xie, Byungchul Lee, Kimberley Bruce, Clara Lawler, Helen E. Farrell, Philip G. Stevenson
Summary: Cytomegalovirus infections commonly cause problems in immunocompromised patients and in pregnancy. We lack effective vaccines. CD4(+) T cells play an important role in normal infection control, yet how they act has been unknown. Using murine cytomegalovirus as an accessible model, we show that CD4(+) T cells are unlikely to recognize infected cells directly. We propose that CD4(+) T cells interact with uninfected cells that present viral antigens and recruit other immune cells to attack infected targets. These data present a new outlook on understanding how CD4(+) T cell-directed control protects against persistent cytomegalovirus infection.
JOURNAL OF VIROLOGY
(2022)
Review
Cell Biology
Sara Becker, Matthias J. Reddehase, Niels A. Lemmermann
Summary: Cytomegaloviruses can cause serious infections in immunocompromised hosts, including those who have undergone hematopoietic cell transplantation. Recent research has found that mast cells play a crucial role in the immune control of lung infection by cytomegaloviruses.
Article
Immunology
Kerstin M. Gergely, Juergen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Buescher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: The study demonstrates that combining ACT and TherVac in HCT recipients significantly improves antiviral control, and the enhancement of antiviral protection through vaccination is strictly epitope-specific.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Franziska Blaum, Dominika Lukas, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: Experimental observations suggest that virus-specific CD8(+) T cells play a critical role in resolving lung infection caused by cytomegalovirus, and these cells may lose certain phenotypes and transform into other types of T cells after transmigration.
Article
Immunology
Yana Hackler, Frank Siebenhaar, Max Loehning, Marcus Maurer, Melba Munoz
Summary: MCs play a critical role in the activation and expansion of virus-specific CD8(+) T cells through proper dendritic cell (DC) activation, and are essential for antiviral functions during viral infections. Depletion of MCs impairs CD8(+) T cell effector phenotype, antiviral cytokine production, and DC activation, resulting in increased viral loads and reduced type-I interferon levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mariona Baliu-Pique, Julia Drylewicz, Xiaoyan Zheng, Lisa Borkner, Arpit C. Swain, Sigrid A. Otto, Rob J. de Boer, Kiki Tesselaar, Luka Cicin-Sain, Jose A. M. Borghans
Summary: Memory T cells play a crucial role in providing immune protection against reinfection and their long-term survival is still a subject of debate. This study suggests that memory phenotype CD8(+) T cells maintain themselves through cell division rather than individual cell longevity. CMV infection induces inflationary CD8(+) T cell responses that may result from the accumulation of long-lived CMV-specific memory CD8(+) T cells. The lifespans and production rates of CMV-specific CD8(+) T cells are similar to those of bulk memory-phenotype CD8(+) T cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Carmen Rozmanic, Berislav Lisnic, Marina Pribanic Matesic, Andrea Mihalic, Lea Hirsl, Eugene Park, Ana Lesac Brizic, Daniela Indenbirken, Ina Viduka, Marina Santic, Barbara Adler, Wayne M. Yokoyama, Astrid Krmpotic, Vanda Juranic Lisnic, Stipan Jonjic, Ilija Brizic
Summary: Infections in early life can have profound and long-lasting effects on the maturation and functionality of NK cells.
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Cristina M. Padilla, Eleanor Valenzi, Tracy Tabib, Banafsheh Nazari, John Sembrat, Mauricio Rojas, Patrizia Fuschiotti, Robert Lafyatis
Summary: This study analyzed lymphoid subpopulations in SSc-ILD lung tissue using single-cell RNA sequencing and found activated NK cells, CD8(+) tissue resident memory T cells, and Treg cells in SSc-ILD lungs. The transition of CD8(+) T cells to tissue resident memory phenotype was observed in SSc-ILD.
Review
Pharmacology & Pharmacy
Guangna Liu, Motao Zhu, Xiao Zhao, Guangjun Nie
Summary: Vaccination has become an effective method to stimulate immunity for disease prevention and treatment, but a tailored efficient delivery system for specific antigens is still urgently needed, especially for vaccines targeting CD8(+) T cells-mediated cellular immunity. Nanotechnology plays a crucial role in enhancing antigen stability and immunogenicity, as well as facilitating APCs-targeted delivery and increased cross-presentation for effective immune protection and clearance.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Article
Immunology
Abrar Ul Haq Khan, Saeedah Musaed Almutairi, Alaa Kassim Ali, Rosalba Salcedo, C. Andrew Stewart, Lisheng Wang, Seung-Hwan Lee
Summary: Natural killer (NK) cells modify their metabolism to support high energy demands during infection, with interleukin-1 family members critical in activating NK cells. Upregulation of nutrient transporters on NK cells can occur through multiple pathways, with MyD88 playing an imperative role in NK cell metabolism during infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Praveen Weeratunga, Laura Denney, Joshua A. Bull, Emmanouela Repapi, Martin Sergeant, Rachel Etherington, Chaitanya Vuppussetty, Gareth D. H. Turner, Colin Clelland, Jeongmin Woo, Amy Cross, Fadi Issa, Carlos Eduardo de Andrea, Ignacio Melero Bermejo, David Sims, Simon McGowan, Yasemin-Xiomara Zurke, David J. Ahern, Eddie C. Gamez, Justin Whalley, Duncan Richards, Paul Klenerman, Claudia Monaco, Irina A. Udalova, Tao Dong, Agne Antanaviciute, Graham Ogg, Julian C. Knight, Helen M. Byrne, Stephen Taylor, Ling-Pei Ho
Summary: This study demonstrates an association between immature neutrophils, CD8 T cells, and proliferating alveolar epithelial cells in areas of maximal alveolar damage in COVID-19 lungs using mathematical tools combined with high-resolution multiplex imaging mass cytometry.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Jennifer L. Vella, Aleksey Molodtsov, Christina Angeles, Bruce R. Branchini, Mary Jo Turk, Yina H. Huang
Summary: Dendritic cells play a crucial role in supporting T-RM responses to melanoma, with their close interaction being essential for maintaining immune protection. Chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis are critical for T-RM migration and persistence in the skin, with the interaction between CXCR6-expressing T-RM cells and CXCL16-expressing APCs being pivotal for sustaining T-RM cell-mediated tumor protection.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Takayuki Chikata, Hiroyuki Gatanaga, Hung The Nguyen, Daisuke Mizushima, Yu Zhang, Nozomi Kuse, Shinichi Oka, Masafumi Takiguchi
Summary: This study investigated HIV-1-specific CD8(+) T cell responses in 200 Japanese HIV-1-exposed seronegative (HESN) men who have sex with men (MSM). The results showed the presence of HLA-B*51:01-restricted Pol TI8- specific and HLA-A*02:06-restricted Pol SV9-specific CD8+ T cells in two and one individuals, respectively. These HIV-1-specific T cells may contribute to suppressing HIV-1 replication in HESN-MSM individuals.
Article
Clinical Neurology
Sarah Dietz-Terjung, Jan Geldmacher, Sebastian Brato, Carolin-Maria Linker, Matthias Welsner, Christoph Schoebel, Christian Taube, Juergen Goetze, Gerhard Weinreich
Summary: This study assessed the diagnostic accuracy of the VitaLog device for estimation of respiratory rate variability in patients with suspected sleep-disordered breathing. The results showed that VitaLog had excellent diagnostic accuracy and worked nearly identically in detecting RR variability in patients with and without SDB.
SLEEP AND BREATHING
(2021)
Review
Oncology
Andrea Pelosi, Piera Filomena Fiore, Sabina Di Matteo, Irene Veneziani, Ignazio Caruana, Stefan Ebert, Enrico Munari, Lorenzo Moretta, Enrico Maggi, Bruno Azzarone
Summary: Neuroblastoma and Wilms' tumor are common childhood solid extracranial tumors, and the challenge lies in developing new therapeutic strategies to reduce adverse effects. Studying the immune environment can identify new therapeutic targets, such as the immunosuppressive activity of tumor cells on natural killer cells and monocytes. Natural killer cells play a crucial role in controlling cancer, but tumor cells can inhibit their function through various mechanisms, including the establishment of an immunosuppressive tumor microenvironment.
Review
Virology
Matthias J. Reddehase, Rafaela Holtappels, Niels A. W. Lemmermann
Summary: Hematopoietic cell transplantation is a last resort for treating hematopoietic malignancies that are refractory to standard therapies, aiming to reconstitute hematopoiesis and immune function. Mismatches in HLA and minor histocompatibility antigens may increase the risk of complications from cytomegalovirus infection.
Article
Immunology
Kerstin M. Gergely, Juergen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Buescher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: The study demonstrates that combining ACT and TherVac in HCT recipients significantly improves antiviral control, and the enhancement of antiviral protection through vaccination is strictly epitope-specific.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Niels A. W. Lemmermann, Matthias J. Reddehase
Summary: Research on murine models of CMV infection has shown a phenomenon called memory inflation after primary CD8(+) T-cell response peaks. During CMV latency, there is an increase in cells specific for certain viral epitopes over time. Additionally, viral genes are not completely silent during latency and are expressed sporadically in a stochastic manner.
Article
Biology
Franziska Blaum, Dominika Lukas, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: Experimental observations suggest that virus-specific CD8(+) T cells play a critical role in resolving lung infection caused by cytomegalovirus, and these cells may lose certain phenotypes and transform into other types of T cells after transmigration.
Article
Endocrinology & Metabolism
Inga Kavazovic, Mia Krapic, Ammarina Beumer-Chuwonpad, Bojan Polic, Tamara Turk Wensveen, Niels A. Lemmermann, Klaas P. J. M. van Gisbergen, Felix M. Wensveen
Summary: Type 2 diabetes leads to impaired antiviral and anticancer capacity of memory CD8 T cells due to hyperglycemia, rather than hyperinsulinemia, in the context of obesity.
Review
Respiratory System
Marek Lommatzsch, Klaus F. Rabe, Christian Taube, Marcus Joest, Michael Kreuter, Hubert Wirtz, Torsten Gerriet Blum, Martin Kolditz, Hilte Geerdes-Fenge, Ralf Otto-Knapp, Brit Haecker, Tom Schaberg, Felix C. Ringshausen, Claus F. Vogelmeier, Niels Reinmuth, Martin Reck, Jens Gottlieb, Stavros Konstantinides, Joachim Meyer, Heinrich Worth, Wolfram Windisch, Tobias Welte, Torsten Bauer
Summary: Assessing the risk for severe courses of COVID-19 in specific patient groups with chronic respiratory conditions is crucial. This review focuses on various respiratory diseases and their association with severe COVID-19. While asthma is not a risk factor, other factors such as age, obesity, gender, and comorbidities need to be considered in assessing the risk.
Review
Virology
Sara Becker, Annette Fink, Juergen Podlech, Matthias J. Reddehase, Niels A. Lemmermann
Summary: Cytomegaloviruses (CMVs) have evolved through private gene families to adapt to their specific mammalian hosts. The host immune response drives viral evolution and the acquisition of immune evasion proteins encoded by private gene families. The mouse model based on murine cytomegalovirus (mCMV) is a versatile tool for studying virus-host interplay. This review focuses on the immune evasion of CD8(+) T cells by mCMV proteins and their role during acute and latent infection.
Article
Respiratory System
Matthias Welsner, Tim Schulte, Sarah Dietz-Terjung, Gerhard Weinreich, Florian Stehling, Christian Taube, Svenja Strassburg, Christoph Schoebel, Sivagurunathan Sutharsan
Summary: Initiation of CFTR triple combination therapy ELX/TEZ/IVA resulted in significant improvements in sleep-disordered breathing (SDB) in people with cystic fibrosis.
Review
Cell Biology
Sara Becker, Matthias J. Reddehase, Niels A. Lemmermann
Summary: Cytomegaloviruses can cause serious infections in immunocompromised hosts, including those who have undergone hematopoietic cell transplantation. Recent research has found that mast cells play a crucial role in the immune control of lung infection by cytomegaloviruses.
Article
Virology
Rafaela Holtappels, Juergen Podlech, Kirsten Freitag, Niels A. Lemmermann, Matthias J. Reddehase
Summary: CMVs are controlled by immune responses in immunocompetent hosts and cause organ diseases in immunocompromised hosts. Adoptive transfer of CMV-specific CD8 T cells can prevent CMV disease. Experimental models show transferred cells can effectively proliferate to prevent virus spread.
Article
Immunology
Melissa Thaler, Ying Wang, Anne M. van der Does, Alen Faiz, Dennis K. Ninaber, Natacha S. Ogando, Hendrik Beckert, Christian Taube, Clarisse Salgado-Benvindo, Eric J. Snijder, Peter J. Bredenbeek, Pieter S. Hiemstra, Martijn J. van Hemert
Summary: The consequences of SARS-CoV-2 infection can range from asymptomatic to fatal disease, and the susceptibility to infection varies depending on the different regions of the respiratory tract. The cellular composition and differentiation of the epithelial cells play a role in the infection process.
JOURNAL OF INNATE IMMUNITY
(2023)
Article
Allergy
Anna Katharina Schober, Moritz Maximilian Hollstein, Regina Treudler, Sven Becker, Jelena Epping, Eckard Hamelmann, Christian Taube, Martin Wagenmann, Bettina Wedi, Margitta Worm, Alexander Zink, Timo Buhl, Thomas Werfel, Stephan Traidl
Summary: This study aims to identify and analyze potential barriers to clinical allergological care in Germany. The results showed that reimbursement and the use of digital healthcare concepts are major barriers in allergological care. There is an urgent need for researchers and policymakers to investigate and support the improvement of allergology departments in Germany.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Immunology
Melissa Thaler, Ying Wang, Anne M. van der Does, Alen Faiz, Dennis K. Ninaber, Natacha S. Ogando, Hendrik Beckert, Christian Taube, Clarisse Salgado-Benvindo, Eric J. Snijder, Peter J. Bredenbeek, Pieter S. Hiemstra, Martijn J. van Hemert
Summary: The cellular biology underlying the variations in epithelial susceptibility to SARS-CoV-2 infection in different anatomical locations of the respiratory tract is not completely understood. This study used air-liquid interface cultures of primary human tracheal and bronchial epithelial cells to investigate the impact of cellular composition and differentiation on SARS-CoV-2 infection. The results showed that SARS-CoV-2 primarily infected ciliated cells, goblet cells, and transient secretory cells. The viral replication was influenced by differences in cellular composition, especially the percentage of ciliated cells. Moreover, the study found that the differentiation time affected the cell entry factors. These findings provide insights into the variable susceptibility to SARS-CoV-2 infection between individuals and anatomical locations in the respiratory tract.
JOURNAL OF INNATE IMMUNITY
(2023)
