Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS

(2015) G. Kunis et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Ontogeny of Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   Frontiers in Immunology

A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

(2015) Martin Guilliams et al.   Frontiers in Immunology

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Glial cells in amyotrophic lateral sclerosis

(2014) T. Philips et al.   EXPERIMENTAL NEUROLOGY

Effect of fluoxetine on disease progression in a mouse model of ALS

(2014) J. E. Koschnitzky et al.   JOURNAL OF NEUROPHYSIOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

(2013) M. de las Casas-Engel et al.   JOURNAL OF IMMUNOLOGY

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Selective Vulnerability of Spinal and Cortical Motor Neuron Subpopulations in delta7 SMA Mice

(2013) Paolo d’Errico et al.   PLoS One

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity

(2012) Christel Dentel et al.   BRAIN

Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease

(2012) Suzanne E. Hickman et al.   CNS & Neurological Disorders-Drug Targets

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Vertebral landmarks for the identification of spinal cord segments in the mouse

(2012) Megan Harrison et al.   NEUROIMAGE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglial pathology in Down syndrome

(2011) Qing-Shan Xue et al.   ACTA NEUROPATHOLOGICA

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers

(2011) Terry D. Heiman-Patterson et al.   Amyotrophic Lateral Sclerosis

The Frontotemporal Syndromes of ALS. Clinicopathological Correlates

(2011) Michael Joseph Strong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology

(2011) M. H. B. Huisman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

5-HT2B receptors are required for serotonin-selective antidepressant actions

(2011) S L Diaz et al.   MOLECULAR PSYCHIATRY

Serotonin receptors and heart valve disease—It was meant 2B

(2011) Joshua D. Hutcheson et al.   PHARMACOLOGY & THERAPEUTICS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

A population-specific HTR2B stop codon predisposes to severe impulsivity

(2010) Laura Bevilacqua et al.   NATURE

Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects

(2010) Sophie M Banas et al.   NEUROPSYCHOPHARMACOLOGY

Platelet Serotonin Level Predicts Survival in Amyotrophic Lateral Sclerosis

(2010) Luc Dupuis et al.   PLoS One

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX3CR1

(2009) Coral-Ann B. Lewis et al.   GLIA

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

(2009) Michael A van Es et al.   NATURE GENETICS

Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease

(2008) Luc Dupuis et al.   EXPERIMENTAL NEUROLOGY

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro

(2008) S. Doly et al.   JOURNAL OF NEUROSCIENCE