Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients

Central nervous system inflammation across the age span

(2016) Amit Bar-Or et al.   CURRENT OPINION IN NEUROLOGY

Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice

(2016) Uma Maheswari Selvaraj et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Anoctamin 2 identified as an autoimmune target in multiple sclerosis

(2016) Burcu Ayoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

(2016) Simone M. Brändle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies in multiple sclerosis oligoclonal bands target debris

(2016) Ryan C. Winger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants

(2015) Kevin Blauth et al.   ACTA NEUROPATHOLOGICA

A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients

(2015) Ann J. Ligocki et al.   ASN Neuro

MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing

(2015) William H. Rounds et al.   GENE

The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

(2015) Markus C Kowarik et al.   Journal of Neuroinflammation

Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins

(2015) Simon N. Willis et al.   Frontiers in Immunology

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

(2015) Eric H. Chang et al.   EBioMedicine

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

Targets of the humoral autoimmune response in multiple sclerosis

(2014) Judith Fraussen et al.   AUTOIMMUNITY REVIEWS

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

(2014) Eduardo Beltrán et al.   BRAIN

Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts

(2014) Guido Heine et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice

(2014) Massimiliano Cristofanilli et al.   EXPERIMENTAL NEUROLOGY

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

The Antibody Genetics of Multiple Sclerosis: Comparing Next-Generation Sequencing to Sanger Sequencing

(2014) William H. Rounds et al.   Frontiers in Neurology

Multiple sclerosis: Prospects and promise

(2013) Stephen L. Hauser et al.   ANNALS OF NEUROLOGY

In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses

(2013) Jaishree Bankoti et al.   ANNALS OF NEUROLOGY

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

(2013) A J Ligocki et al.   GENES AND IMMUNITY

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

(2013) Tuure Kinnunen et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis

(2013) Lenka Fialová et al.   JOURNAL OF NEUROIMMUNOLOGY

Plasmablasts as Migratory IgG-Producing Cells in the Pathogenesis of Neuromyelitis Optica

(2013) Norio Chihara et al.   PLoS One

Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis

(2012) Christina Elliott et al.   BRAIN

B cell exchange across the blood-brain barrier in multiple sclerosis

(2012) H.-Christian von Büdingen et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells and antibodies in multiple sclerosis pathogenesis and therapy

(2012) Markus Krumbholz et al.   Nature Reviews Neurology

The evidence for a role of B cells in multiple sclerosis

(2012) G. Disanto et al.   NEUROLOGY

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

(2012) Rajneesh Srivastava et al.   NEW ENGLAND JOURNAL OF MEDICINE

Origin and Function of Circulating Plasmablasts during Acute Viral Infections

(2012) Katja Fink   Frontiers in Immunology

Autoantibodies to intracellular antigens: Generation and pathogenetic role

(2011) Vito Racanelli et al.   AUTOIMMUNITY REVIEWS

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating Human Antibody-Secreting Cells during Vaccinations and Respiratory Viral Infections Are Characterized by High Specificity and Lack of Bystander Effect

(2011) F. E.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

Antinuclear and antiphospholipid antibodies in patients with multiple sclerosis

(2011) M Szmyrka-Kaczmarek et al.   LUPUS

MS and the B cell controversy

(2010) Anne H. Cross et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The blood–brain barrier, chemokines and multiple sclerosis

(2010) David W. Holman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells

(2010) D. Frolich et al.   JOURNAL OF IMMUNOLOGY

Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes

(2010) John DE Parratt et al.   Multiple Sclerosis Journal

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid

(2009) Gregory P. Owens et al.   ANNALS OF NEUROLOGY

HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus

(2009) A M Jacobi et al.   ANNALS OF THE RHEUMATIC DISEASES

A nucleic acid-hydrolyzing antibody penetrates into cells via caveolae-mediated endocytosis, localizes in the cytosol and exhibits cytotoxicity

(2009) J. Y. Jang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential

(2009) Jie Zhang et al.   JOURNAL OF AUTOIMMUNITY

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis☆

(2009) Elizabeth M. Cameron et al.   JOURNAL OF NEUROIMMUNOLOGY

Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”

(2009) Hans-Christian von Büdingen et al.   JOURNAL OF NEUROIMMUNOLOGY

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

(2008) Erin E. McCandless et al.   AMERICAN JOURNAL OF PATHOLOGY

Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies

(2008) Hans‐Christian von Büdingen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalizationviaelectrostatic interactions

(2008) Ying-Chyi Song et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome

(2008) Jeffrey L. Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma cell development: From B-cell subsets to long-term survival niches

(2008) Kirsten A. Fairfax et al.   SEMINARS IN IMMUNOLOGY

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS